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Biomedical subjects

L Georgescu

Publications and source records attributed to L Georgescu.

90 records · Page 5Linked to original sources
PubMedDate not supplied

Importance of morpho-clinical correlations in the diagnosis of congestive cardiomyopathies.

A morphologic score was performed in 17 myocardial biopsy specimens proceeding from patients with congestive cardiomyopathies. The electron microscopic changes were estimated according to their frequency and severity. According to this score, the morphological findings were compared with the clinical data and some echographic indexes of the myocardial contractility. These correlations turned out to be of great value in estimating the prognosis of these patients and allowed to set up three different stages of evolution in the congestive cardiomyopathies.

Biopsy↗
PubMedDate not supplied

Polymorphism of nuclear inclusions in carcinoma of the cervix uteri.

Frequency, polymorphism and ultrastructural characteristics of the nuclear inclusion bodies encountered in cancers of the uterine cervix are reported and briefly discussed. The nuclear inclusions are grouped in three distinct types: a) nuclear bodies (comprising type I and II inclusions according to Bouteille et al.'s classification), b) inclusion of cytoplasmic origin, and c) particles of chromatic material. The ultrastructural aspects of the chromatic particles suggest an early structuration of viral chromatin into core material. There appears to be a direct relation between the frequency of chromatic particles and raised antiherpetic antibodies in the patient's sera.

Adult↗
PubMedDate not supplied

Phosphonoacetic acid-induced morphological changes of herpesvirus growth in vitro.

Thin-section electron microscopy of Herpesvirus hominis type 1 (HV-1)-infected HEp-2 cells exposed to 100 micrograms/ml phosphonoacetic acid (PAA) revealed not only a spatial restriction of virus multiplication to a few spheroid bodies in the nucleus, but also a delay in viral development, resulting in the formation of unusual HV-1 particle rosettes around the spheroid bodies. HV-1-infected cells were lacking, however, the small tubular structures known to accumulate at increased rates in the presence of PAA, in HV-2-infected cells.

Capsid↗
PubMedDate not supplied

Ultrastructural aspects of herpetoviruses.

Thin-section electron microscopy of several herpetovirus strains recovered in the laboratory from human hosts and rodents visualized typical spherical particles when the strains were propagated in vitro at a temperature corresponding to the body temperature of their natural host. In contrast, viral growth at a suboptimal temperature often resulted in aberrant viral structures.

Animals↗
PubMedDate not supplied

Atherogenic risk in obese and in diabetic children.

By a complex biochemical, immunologic, morphohistochemical and ultrastructural study, carried out on a group of 42 obese and 38 diabetic children, comparatively with 12 normal controls, the authors arrive at conclusions which prove that obesity and diabetes mellitus carry great atherogenic risk factors. Even though the intimate atherogenesis mechanism is not perfectly known, the abnormal values of insulinemia, lipidemia and cortisolemia are certainly involved in this process. In diabetes mellitus the immunologic factor is also involved. Microangiopathy in diabetes mellitus and capillary lesions in the adipose tissue of obese children may also represent atherogenic risk factors. An efficient prophylaxis in atherosclerosis must therefore begin in childhood.

Adipose Tissue↗