Biomedical subjects
L Gatenbeck
Publications and source records attributed to L Gatenbeck.
Predictive sites of inflammatory manifestation in the prostatic gland: an experimental study on nonbacterial prostatitis in the rat.
In rats that had been subjected to standardized experimental stress stimuli for 3 and 10 days, respectively, prostatic inflammatory changes of type nonbacterial prostatitis were found in a lobe-differentiated histological examination. The inflammatory manifestations were marked in the ventral lobes, whereas they were sparse in the dorsolateral lobes. The lobe difference in this respect corresponds to a concomitant difference in morphology and tissue chemical content.
Stress stimuli-induced histopathological changes in the prostate: an experimental study in the rat.
To elucidate a suggested relationship between stress stimuli and prostatis, a histological study on the genital organs of seven rats was performed. The specimens were histopathologically examined after a 10-day period, during which the rats had been submitted to standardized stress stimuli, and compared with corresponding organs from a control group of seven male rats. Inflammatory histopathological changes and large numbers of inflammatory cells were seen in the prostatic glands of all rats submitted to the long-term stress stimuli. The findings agreed with those from the prostatic glands of human males with prostatis. No corresponding changes were observed in the control group. There was no evidence indicating a bacterial origin. The results indicate a connection between stress stimuli and prostatitis.
Blood perfusion of the male genital organs--an experimental study in the rat.
Male genital blood flow and its regulation have not been fully clarified. In the present study we employed a radioactive microsphere technique to estimate the blood flow simultaneously in the major urogenital organs of male rats. The recorded genital flow rates varied among the rats. The relative blood perfusion rates of the testicles, seminal vesicles and kidneys did not differ from one animal to another. However, the blood flow in the prostate gland was not correlated to the perfusion of any of the other investigated urogenital organs.
Genital blood flow in male rats subjected to stress stimuli.
A common opinion among physicians is that some symptoms from the prostate gland are stress-dependent. However, no experimental support for this view has been presented. In the present study blood perfusion of the major genital organs of male rats were measured after they had been subjected to experimental "short- and long-term" stress stimuli. The blood-flow measurements were made by means of a radioactive microsphere technique. The used experimental "short-term" stress reduced the prostatic blood flow by approximately 50 percent. A decreased blood flow and a concomitant atrophy, indicating that the reduction in blood flow has been in force over a prolonged period of time, were noticed in all examined genital organs of the rats subjected to prolonged stress stimuli. The decreases in blood flow and weight were most pronounced in the prostate gland.
Plasma testosterone concentrations in male rats during short and long-term stress stimulation.
Plasma testosterone concentrations were analysed in 14 male rats submitted to short-term and prolonged stress stimulation, and the results were compared with those obtained from a control group of seven rats not submitted to the corresponding experimental stress stimuli. Increased levels of circulating testosterone were recorded during the short term stress stimulus. As compared with the control group, plasma testosterone concentrations were reduced after prolonged stress stimulation for 10 days. The increased stress stimulation, that the animals subjected to short- and long-term standardized stress stimuli were subjected to, compared to the corresponding stress of the animals in the control group, was reflected in an increased concentration of catecholamines in arterial blood.
Stress stimuli and the prostatic gland--an experimental study in the rat.
A suggested relationship between stress stimuli--a reduced prostatic blood flow--and non-acute prostatitis, was investigated. Blood flows in the major genital organs of male Sprague-Dawley rats were measured after they had been subjected to standardized experimental short-term and protracted (10 days) stress stimuli. The blood-flow measurements were made by means of a radioactive microsphere method. The used stress stimuli reduced the prostatic blood flow by approximately 50 per cent. As compared with a control group, plasma testosterone concentrations, were reduced in rats submitted to stress stimuli for 10 days. Inflammatory histopathological changes and large numbers of inflammatory cells were seen in the prostatic glands of rats submitted to stress stimuli for 10 days. The findings were in accordance with those considered as characteristic for non-acute prostatitis in man. No corresponding changes were observed in a control group. There was no evidence indicating a bacterial infection. The inflammatory manifestations predominated in the ventral lobes while the dorsolateral ones were almost unaffected. The ventral lobes of the rat prostate have a less advanced drainage system and a lower zinc content than the dorsolateral lobes. The results verify a causal connection between protracted experimental stress stimuli and an inflammatory reaction in the prostatic gland in rats. The mechanism may be a stress stimuli induced decreased blood perfusion of the gland. Stress stimuli seem to be of importance in the pathogenesis of non-acute prostatitis in man.
[Spontaneous recanalization after vasectomy--a review].
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Spontaneous recanalisation after vasectomy. A case report.
Spontaneous recanalisation of the vas deferens is a wellknown but seldom seen complication to vasectomy. The recanalisation process is initiated in a spermatic granuloma. The present case report describes a recanalized vas deferens.
Bleeding during transurethral prostatectomy. Is preoperative blood request necessary?
Transurethral resection of the prostate is nowadays the totally dominating operation for prostatic hyperplasia. The most common and also most discussed complication is per- and postoperative bleeding. To find out how often there is need for blood transfusion in connection with transurethral prostatectomy we analyzed all such operations performed during 1981 at the Urological clinic, Danderyd Hospital. The study showed that transfusion was given in 13% of the operations. The amount of given blood was generally small. The conclusion is that there is no need for routine request of blood preoperatively at transurethral resections of the prostate.