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Biomedical subjects

L G Phillips

Publications and source records attributed to L G Phillips.

At least 73 records · Page 4Linked to original sources
PubMed1986

Parelaphostrongylus tenuis in captive reindeer and sable antelope.

Parelaphostrongylus tenuis caused neurologic disease in 6 reindeer (Rangifer tarandus tarandus) and 2 sable antelope (Hippotragus niger) that were housed at the National Zoological Park Conservation and Research Center in Front Royal, Va. Progressive hindlimb ataxia and weakness were seen in all affected animals. The parasite was recovered from the subdural space of one reindeer and was seen histologically within the neuropil of another reindeer and a sable antelope. In the other reindeer and sable antelope, diagnoses of parelaphostrongylosis were based on clinicoepidemiologic findings and microscopic lesions. Because parelaphostrongylosis is a density-dependent disease and because the number of white-tailed deer probably will increase, the incidence of P tenuis infections in domestic and nondomestic animals probably will increase as well. Zoos and wildlife parks especially should be cautious when introducing exotic hoofstock to areas with Parelaphostrongylus tenuis-infected white-tailed deer.

Animals↗
PubMed1986

Genetic variation within and among lion tamarins.

The golden lion tamarin Leontopithecus rosalia rosalia, one of the rarest and most endangered of New World primates, has been the focus of an intensive research and conservation effort for two decades. During that period, managed breeding from 44 founders has brought the captive population to over 400 individuals, a number that equals or exceeds the estimated number of free-ranging golden lion tamarins. The extent of genetic variation among golden lion tamarins was estimated with an electrophoretic survey of 47 allozyme loci from 67 captive and 73 free-ranging individuals. The amount of variation was low, compared to 15 other primate species, with 4% of the loci being polymorphic (P), and with an average heterozygosity H estimate of 0.01 in these callitrichids. Electrophoretic analyses of captive and free-ranging animals (N = 31) of two allopatric morphotypes, Leontopithecus rosalia chrysopygus and L. r. chrysomelas, were similar to the L. r. rosalia findings insofar as they also revealed limited genetic polymorphism. Computation of the Nei-genetic distance measurements showed that the three morphotypes were genetically very similar, although discernible differentiation had occurred at two loci. These data are consistent with the occurrence of recent reproductive isolations of these subspecies.

Animals↗
PubMed1986

Therapeutic efficacy of Biobrane in partial- and full-thickness thermal injury.

Cadaver allograft skin, porcine xenograft skin, and amniotic membranes have been proved to be adequate temporary thermal wound coverings in four clinical situations: coverage of shallow wounds while awaiting epithelialization (SW), coverage of deep wounds after eschar excision (DEW), coverage of widely meshed autograft while awaiting closure of interstices (AC), and coverage of massive donor sites (DS). This study was undertaken to evaluate the therapeutic efficacy of a new biosynthetic bilaminate dressing, Biobrane. Two hundred one applications of Biobrane were studied in 82 SW, 46 DEW, 19 AC, 54 DS. A total of 124 applications were left in place until healing occurred, with a mean healing time of 12.8 days. Sixty of SW, 10/46 DEW, 10/19 AC, and 44/54 DS remained intact until complete healing. Only four DEW, two SW, and 0 AC applications had to be removed because of suppuration. Twenty five of the applications (SW and DEW) with the Biobrane glove had rare complications.

Adhesiveness↗
PubMed1984

Esophageal perforation.

A brief synopsis of the clinical and radiographic features of esophageal perforation, including barogenic rupture, is outlined. The dependence of the thoracic surgeon on roentgenograms and their interpretation by the radiologist is emphasized.

Esophageal Perforation↗
PubMed1984

Carcinoma of the lung and coexistent active pulmonary tuberculosis: diverse morphologic and radiographic presentations.

Five patients with coexistent carcinoma of the lung and active tuberculosis within the same pulmonary lesion were studied. These cases represent five distinctly varying radiographic presentations and point out the extreme diversity of the morphological pictures of this particular disease combination. Physicians who regularly deal with patients who might present with either entity alone are cautioned to be alert to the possibility that these two diseases may be present simultaneously within single, specific pulmonary lesions.

Adenocarcinoma↗
PubMed1983

Giant esophageal carcinoma.

Carcinoma of the esophagus is a devastating disease that produces various degrees of esophageal obstruction by virtue of its circumferential, constricting type of growth pattern. Because of the relatively small diameter of the esophageal lumen, a limited-sized tumor can produce severe obstructive symptoms. Carcinoma of the esophagus is, as a rule, fairly well localized to its wall or the immediate mediastinal parietes in cases where there is extension beyond the esophageal musculature.(1) Large, bulky, exophytic types of esophageal carcinomas that produce symptoms mainly as a result of extrinsic pressure are unusual.

Carcinoma, Squamous Cell↗
PubMed1983

A nonclassifiable anaplastic tumor of the esophagus.

A highly malignant, anaplastic tumor of the esophagus in a middle-aged man is described. Despite critical examination of biopsy material by several pathologists, the tumor was deemed to be anaplastic and sarcomatous but otherwise unclassifiable. Despite prompt diagnosis following admission, the tumor metastasized and the patient rapidly died.

Anaplasia↗
PubMed1982

Gonadotropin regimen for inducing ovarian activity in captive wild felids.

Five species of felids (cheetah, North Chinese leopard, tiger, lion, and puma) were serially injected with a source of follicle-stimulating hormone (FSH) to evaluate its effect on ovarian activity. Animals were subjected to laparoscopy before and after gonadotropin treatment, and the number and appearance of mature ovarian follicles (MF), corpora hemorrhagica (CH), and corpora lutea (CL) were recorded and photographed. Ovarian morphologic features, including MF, CH, and CL anatomy, were similar among various species. A dosage of 10 mg of FSH given IM daily for 3 to 5 days was effective in stimulating ovulation in 8 of 8 cheetahs. The same dosage for 5 days stimulated ovulation in 6 of 7 North Chinese leopards, 4 of 7 tigers, 2 lions, and 1 puma. An injection of a luteinizing hormone source was not required to induce follicular rupture. The number of ovulations eventually obtained appeared related to the activity prior to FSH treatment. Females with evidence of follicular development prior to treatment eventually produced a combined average (+/- SEM) of 5.2 +/- 1.3 CH and CL, in comparison with 2.3 +/- 0.8 CH and CL observed in cats with no identifiable follicles before FSH injection. The species varied in the number of ovulation sites (combined number of CH and CL) after treatment, with the cheetahs, leopards, tigers, lions, and puma producing a mean of 5.5 +/- 0.9, 1.5 +/- 0.2, 4.7 +/- 3.1, 1.5 +/- 0.5, and 3.0 +/- 0.0, respectively. The cheetahs, North Chinese leopards, and tigers failed to develop a refractory response to the gonadotropin, as certain females receiving FSH twice at a 1-year interval produced a similar ovulatory response.

Animals↗
PubMed1982

Barogenic rupture of the esophagus (Boerhaave's syndrome): successful treatment of a late case.

This article presents a case of barogenic (postemetic) rupture of the esophagus that was diagnosed more than 48 hours after the acute event and subsequently treated successfully. The initial approach of direct esophageal repair, pleural drainage, antibiotics, and intravenous hyperalimentation was not successful. The repair site disrupted, and the patient became critically ill and septic. Salvage of the patient with closure of the fistula and normal alimentation was accomplished by partial distal esophageal occlusion, utilizing a serrated (Miles) vena cava clip.

Constriction↗
PubMed1981

Polyposis and carcinoma of the small bowel and familial colonic polyposis.

This article reviews a case of small-bowel polyposis associated with a primary jejunal adenocarcinoma in a patient who had previously undergone a subtotal colectomy for familial colonic polyposis. The patient was seen for a spontaneously resolving, subacute small-bowel obstruction secondary to metastatic mesenteric and serosal nodules. The jejunal malignancy was metastatic to the lungs in the form of lymphangitic spread, the patient subsequently dying after an open-lung biopsy in an attempt to establish a diagnosis. This particular combination of clinical features, especially the pulmonary findings, appears not to have been previously reported.

Adenocarcinoma↗