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Biomedical subjects

L G Lefer

Publications and source records attributed to L G Lefer.

At least 19 recordsLinked to original sources
PubMed1984

Pseudobullous malignant melanoma in situ. A pitfall in diagnosis.

A biopsied specimen of a pink lesion on the knee of a 21-year-old woman showed histologic features of subepidermal vesicular dermatitis. Further studies disclosed diagnostic features of malignant melanoma in situ, and additional clinical data corroborated the diagnosis.

Adult↗
PubMed1979

Ochronosis in the breast.

A patient who had masses in the breasts clinically suggestive of neoplasia had fibrous mastopathy and striking deposition of ochronotic pigment within the soft tissue of the breast. The gross appearance and light microscopic features are illustrated. The histochemical features of ochronotic pigment and the difficulty in differentiating it from melanin are discussed.

Arteries↗
PubMed1975

Liver disease caused by propylthiouracil.

This report presents the clinical, laboratory, and light and electron microscopic observations on a patient with chronic active (aggressive) hepatitis caused by the administration of propylthiouracil. This is an addition to the list of drugs that must be considered in the evaluation of chronic liver disease.

Chemical and Drug Induced Liver Injury↗
PubMed1975

Intranuclear inclusions in Bence Jones lambda plasma cell myeloma.

A patient with plasma cell myeloma producing only Bence Jones lambda protein was found to have pale intranuclear inclusions in the majority of the bone marrow plasma cells. These inclusions, previously undescribed in myeloma patients producing only Bence Jones protein, contained Bence Jones lambda protein, were non-electron dense, bound by a single membrane, and contained no cytoplasmic structures. Intracytoplasmic inclusions were not present, and the perinuclear cistern was not dilated. Thus, the inclusions may represent intranuclear protein synthesis with anomalous release in the abnormal cells.

Bence Jones Protein↗
PubMedDate not supplied

Electron microscopic observations on sputum in alveolar cell carcinoma.

This paper reports the techniques and results from the use of electron microscopy to augment the routine cytopathologic study of cells in sputum. The material for study consisted of specimens of sputum taken from a 75 year old white woman. The patient later died three months after the beginning of radiotherapy for alveolar cell carcinoma of the lung. Light microscopy revealed a homogenous population of cells, obviously malignant, and interpreted as being derived from alveolar cell carcinoma. Electron microscopic study showed prominent microvilli, numerous mitochondria, multiple foci of well-developed Golgi apparatus, and several types of lysosomes. The ultrastructure of these cells resembled that which has been described for type II alveolar cells from the lung.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

The cytology of chordoma.

A case is presented in which touch imprints of a neoplasm revealed cells with fine bubbly cytoplasm and intracytoplasmic vacuoles with indentation and displacement of cell nuclei. The cytology of these bubbly or physaliferous cells was useful in establishing the diagnosis of chordoma and in the differential diagnosis of similar soft tissue lesions.

Aged↗