Biomedical subjects
L G Koss
Publications and source records attributed to L G Koss.
Use of the esophageal balloon in the diagnosis of carcinomas of the head, neck and upper gastrointestinal tract.
A study was undertaken to demonstrate the safety, efficacy and value of esophageal balloon cytology in the diagnosis of esophageal lesions and as a tool in screening a high-risk patient population. The sampling was performed 110 times on 96 patients, 11 with known obstructive carcinoma of the esophagus and 85 thought to be at risk for esophageal cancer: 74 with treated or untreated cancer of the head and neck area and 11 with dysphagia or other findings requiring clarification. The method was well tolerated by the patients, and the cytologic smears were of excellent quality. Malignant or suspicious cells were found in smears from 7 to 11 patients with documented esophageal cancer and in 7 of 85 patients believed to be at risk. In the latter group there were three unsuspected recurrent cancers of the oropharyngeal region and one unsuspected carcinoma in situ of the esophagus. There were no false-suspicious or false-positive results. This noninvasive technique of esophageal cytology obviously deserves additional trials as an adjunct in the diagnosis of carcinoma of the head and neck and upper gastrointestinal tract, especially in high-risk patients.
Aspiration biopsy cytology.
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The attack on the annual 'Pap smear'.
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Thin needle aspiration biopsy.
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Environmental carcinogenesis and cytology.
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Renal oncocytoma: preoperative diagnosis by aspiration biopsy.
The cytologic, histologic and ultrastructural features of an oncocytoma of the right kidney with the primary diagnosis by thin needle aspiration biopsy are presented. These uncommon tumors are generally considered to be of renal tubular origin and are thought to be benign. In the case reported below, two separate tumor masses were present within the diseased kidney; one of them extended to the perirenal adipose tissue and was accompanied by satellite tumor nodules. This presentation of oncocytoma, associated with focal cellular atypia, suggests that malignant behavior of at least some of these tumors may be anticipated.
Detection of endometrial carcinoma in asymptomatic peri- and postmenopausal women [proceedings].
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T and B lymphocyte enumeration in the diagnosis of lymphocyte-rich pleural fluids.
The presence of a monotonous population of small lymphocytes in effusions may be due to chronic lymphatic leukemia (CLL), malignant lymphoma of the small cell type (SLML) or a chronic inflammatory process, such as tuberculosis. In this report we provide evidence that the enumeration of T and B lymphocytes in such fluids may provide a reliable means of distinguishing between malignant and nonmalignant effusions. The mean percentage of T lymphocytes in th pleural effusions of ten patients wit nonmalignant diseases was 80.2, and the mean percentage of B lymphocytes was 7.4. In marked contrast, B cells predominated (mean, 83.3%) in the pleural effusions of patients with lymphoma or leukemia. Since the great majority of chronic lymphocytic lymphomas and leukemias are of B-cell origin, we conclude that effusions containing a large predominance of B cells have a high probability of being malignant. Those that contain a predominance of T cells are almost always benign, although one should always consider the rare occurrence of chronic lymphocytic lymphomas and leukemias of T-cell origin.
Urinary cytology: device capabilities and requirements.
The practical and theoretical considerations leading to the automated diagnostic assessment of cells in the urinary sediment by a computer-based, high-resolution system are discussed. Problems of sample preparations, sample-size requirements, coefficients of variation and computer-generated features are summarized. There are no major theoretical obstacles to achieving a workable system for the diagnosis of high-grade urothelial cancer by the proposed approach.
On the history of cytology.
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The monodisperse cervical smear: quantitative analysis of cell dispersion and loss with enzymatic and chemical agents.
The proper utilization of flow-through instruments for the automatic detection of malignant cells in human cervical specimens requires that the cells be in the form of a monodisperse suspension. Information regarding the degree of cell dispersion and of cell loss is therefore of critical importance in the evaluation of any procedure used to render cervical specimens monodispe automatic detection of malignant cells in human cervical specimens requires that the cells be in the form of a monodisperse suspension. Information regarding the degree of cell dispersion and of cell loss is therefore of critical importance in the evaluation of any procedure used to render cervical specimens monodispe automatic detection of malignant cells in human cervical specimens requires that the cells be in the form of a monodisperse suspension. Information regarding the degree of cell dispersion and of cell loss is therefore of critical importance in the evaluation of any procedure used to render cervical specimens monodisperse. We have devised a simple method for the simultaneous assessment of these two parameters using smears prepared with the Perkin-Elmer Uni-Smear Spinner. Our quantitative evaluation indicates that none of the 15 enzymatic and chemical agents tested to disperse cervical specimens produced an adequate monodispersed cell suspension without unacceptable cell loss. Electron microscopic evidence is used to illustrate the deleterious effects of some of the agents employed.