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Biomedical subjects

L G Kiloh

Publications and source records attributed to L G Kiloh.

At least 37 records · Page 2Linked to original sources
PubMed1977

Psychosurgery.

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Government Regulation↗
PubMed1977

Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia.

Principal component analyses were carried out on 51 items abstracted from Lewis's 1934 and 1936 papers. The first component was bipolar, differentiating between endogenous items and those that were mainly neurotic. The distributions of the first component scores by cluster indicated that there were two separate clusters of patients, one mainly endogenous, the other neurotic. It was concluded that Lewis's data indicate that there are at least two qualitatively different depressive illnesses. Further component analyses were carried out using the 25 endogenous items. The first component was a general one of endogenous depression. The distributions of its scores were bimodal, indicating that there were two groups of patients, those who suffered from endogenous depression and those who did not. These analyses indicated that endogenous depression is a categorical illness.

Adjustment Disorders↗
PubMed1976

The investigation of dementia: the results in 100 consecutive admissions.

One hundred patients admitted consecutively to the Neuropsychiatric Institute, each with the provisional diagnosis of dementia, were investigated. The diagnosis was confirmed in 81 patients. Amongst these, a potentially reversible cause was found in eight patients. Eleven patients were found to have potentially treatable pseudodementing illnesses and eight patients were found to have a chronic organic brain syndrome not characterized by intellectual deterioration. It is recommended that all patients with provisional diagnoses of dementia be investigated early in the course of their illnesses, in the anticipation of finding a reversible dementia or a treatable pseudodementing illness. The investigations can be conducted more efficiently in specialist units, staffed with neurologists and psychiatrists, and having easy access to pathology, neuroradiology, nuclear medicine and computerized axial tomography facilities.

Adult↗
PubMed1976

A prospective evaluation of open prefrontal leucotomy.

Forty-three patients received an open prefrontal leucotomy for severe and intractable psychiatric illnesses. As a result of the operation three patients died, three developed personality changes and one had repeated grand-mal seizures. Of the 40 patients followed up for six months, 57-5% showed marked improvement in their clinical state and 30-0% mild to moderate degrees of improvement whilst no patient's condition was considered to be worse. Significant improvement was obtained after operation in the mean scores on the Hamilton Anxiety Scale, the Hamilton Depression Scale, the Beck Depression Scale and the Neuroticism Scale of the Eysenck Personality Inventory. Extroversion, as measured by the Eysenck Personality Inventory, was significantly increased after operation. It is recommended that open prefrontal leucotomy procedures be replaced by the safer stereotactic or electrode implantation techniques and that all psychosurgery be confined to specialist units.

Adult↗
PubMed1976

A double-blind comparative trial of loxapine and trifluoperazine in acute and chronic schizophrenic patients.

A double-blind comparative trial of loxapine and trifluoperazine was carried out in 57 acute and chronic schizophrenic patients. In both groups of patients loxapine proved to be equivalent in its effects to trifluoperazine and there were suggestions it might be rather more effective in chronic patients. Side-effects were similar with the two drugs but anticholinergic effects, excitement, dizziness and faintness occurred rather more commonly with loxapine. Laboratory tests, urine analysis, cardiovascular and ophthalmological investigations showed no significant abnormalities.

Acute Disease↗
PubMed1974

Stereotactic amygdaloidotomy for aggressive behaviour.

Amygdaloidotomy was performed bilaterally on 15 and unilaterally on three patients exhibiting severe aggressive or self-mutilating behaviour. Nine subjects (50%) were improved a year after operation; improvement was maintained in seven (39%) for periods ranging from 27 months to nearly six years. Four non-epileptic cases had convulsions during the period of review; one of them has a persistent mild hemiparesis dating from the postoperative period. There was a tendency for epileptics to respond better than non-epileptics and for mentally retarded patients to respond poorly, but none of the differences was statistically significant.

Adolescent↗