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Biomedical subjects

L G Hansen

Publications and source records attributed to L G Hansen.

At least 127 records · Page 7Linked to original sources
PubMed1976

Effects of sewage sludge-fertilized corn fed to growing swine.

Swine (2 groups) fed a ration containing 79% corn from sewage sludge-fertilized plots for 8 weeks may have had a modest performance advantage over swine fed corn from plots heavily fertilized with commercial nitrogen. Sludge-fertilized corn feeding-related deviations from population normals for electroencephalograms, electrocardiograms, clinical chemistry, or histopathology were not observed; however, swine fed sludge-fertilized corn differed significantly from the control swine for certain physiologic and biological characteristics, indicating possible interference with glucose metabolism and microsomal mixed-function oxidase activity. Control swine had mild microcytic anemia associated with parasitism, but swine in the principal groups were less adversely affected, probably due to higher iron intake. Corn heavily fertilized with sewage sludge from an urban-industrial complex can be safely fed to swine, based on these results, but it might be advantageous to feed on a short-term or intermittent schedule. Residues of heavy metals in the animal products must be examined.

Animal Feed↗
PubMed1975

Pharmacokinetics of polychlorinated biphenyl components in swine and sheep after a single oral dose.

Single-dose oral administration of a commercial polychlorinated biphenyl product containing 54% chlorine provided data with which to plot the time course of total polychlorinated biphenyl and individual components in the blood of swine and sheep. Pharmacokinetic parameters describing absorption from the gut and elimination from a two-compartment body system were determined for the components in swine and sheep. The absorption half-time for total polychlorinated biphenyl in swine was 1.13 hr while that for sheep was 3.83 hr. The half-time for disposition of total polychlorinated biphenyl from the central compartment was 4.4 hr in swine and 7.7 hr in sheep; the apparent biological half-life was 62.4 hr in swine and 78.8 hr in sheep. Individual components varied significantly from each other and from total polychlorinated biphenyl in all parameters.

Animals↗
PubMed1975

Effects of purified polychlorinated biphenyl analogs on chicken reproduction.

Polychlorinated biphenyl (PCB) compounds were administered in the diet to White Leghorm pullets for 10 weeks. Average embryonic mortality in eggs from pullets fed Aroclor 1242, Aroclor 1254 and 2,4,5,3',4',-pentachloro-biphenyl was 54.7, 59.2 and 74.0 percent, respectively, which was significantly high (p less than .001) compared to controls; however, these three feeds were shown qualitatively to have dibenzodioxin contamination. Degree of chlorination of PCB analogs may not infer that they are toxic, but rather, the position of substitution may be the factor that determines the toxicity to developing embryos.

Administration, Oral↗
PubMed1975

Effect of a polychlorinated biphenyl mixture on swine reproduction and tissue residues.

A commercial polychlorinated biphenyl (PCB) mixture containing 42% chlorine by weight was fed at the dose level of 20 ppm to 3rd-litter sows throughout gestation and nursing. Treated sows differed significantly (0.05% level) from control sows in the number of live pigs they farrowed. Treated sows also had more mummified fetuses. Performance of live-born pigs was not affected by feeding PCB to the sows during nursing. Pathologic changes in the sows included hypertrophy of liver and erosion of stomach. Two treated sows, 1 of which did not conceive, had signs of extensive chronic septicemia. Slight atrophy of spleen and thyroid gland was observed in pigs from treated sows. Blood and tissue residues of PCB were less than 0.5 ppm in both sows and pigs, but the relative amounts of PCB components varied among sows and pigs, as well as among tissues. Fat concentrations of total PCB in sows ranged from 4 to 20 ppm and those of component residues varied from 0 to 60 ppm.

Adipose Tissue↗