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Biomedical subjects

L G Dickson

Publications and source records attributed to L G Dickson.

25 records · Page 2Linked to original sources
PubMed1969

Environmentally-induced changes in the Fatty acids of chlorella.

Qualitative and quantitative analyses were made of the major fatty acids of Chlorella fusca, Shihira and Krauss, in both autotrophic and heterotrophic culture. Cells grown heterotrophically were subjected to CO(2) concentrations as great as 40%-in-air.The major fatty acids of autotrophic cells grown under a 1% environmental concentration of CO(2), in order of concentration were 16:0, 18:3, 16:4, 18:2, 18:1, and 16:3. The analysis of heterotrophic cells at 1% CO(2), by comparison, indicated a complete absence of 16:4, reduced amounts of 18:3, and increased amounts of the other major acids.An increase in the environmental concentration of CO(2) (from 1%-30%) over the heterotrophic cultures produced a 40% increase in total lipids and nearly a 50% increase in fatty acids. Palmitic acid (16:0) and 18:1 largely account for the fatty acid change by increasing from 12 mg to 33 mg/g dry wt and 8 mg to 17 mg/g dry wt respectively. Possible explanations for this enhanced synthesis of fatty acids are suggested.

Journal Article↗
PubMedDate not supplied

Positive antiglobulin tests due to intravenous immunoglobulin in patients who received bone marrow transplant.

To investigate an increased frequency of positive direct (DAT) and indirect (IAT) antiglobulin tests in bone marrow transplant (BMT) patients who received intravenous immunoglobulin (IVIG), serologic testing was performed weekly on blood samples from 94 consecutive BMT patients. Group 1 (47 patients) did not receive IVIG. Group II (47 patients) received high-dose IVIG as prophylaxis for cytomegalovirus infections. Before transplantation no alloantibodies were found in the serums of 92 patients and anti-E was found in the serums of two patients. DATs were negative in all patients before BMT. Four percent of Group I had a positive IAT and 13 percent had a positive DAT. In contrast, 25.5 percent of Group II patients had a positive IAT and 49 percent had a positive DAT, usually within 1 week after initiation of IVIG therapy (p less than 0.001). Antibodies identified in serums and eluates of patients in Group I were anti-A and anti-B. Antibodies identified in serums and eluates of patients in Group II were anti-A, -B, -D, and -K. Twenty-one lots of IVIG were tested and antibodies identified were anti-A, -B, -D, and -K. The data suggest that the higher frequency of positive serologic tests in Group II was due to passively acquired antibodies from high-dose IVIG.

ABO Blood-Group System↗
PubMedDate not supplied

Understanding iron absorption and metabolism, aided by studies of hemochromatosis.

Duodenal iron absorption from food is selectively blocked to prevent iron intoxication. The prime example of pathologic increase in intestinal iron absorption is seen in patients with hemochromatosis. They suffer iron damage to the heart, liver, and other tissues resulting in premature death if the iron is not removed by vigorous phlebotomy. Examples of overcoming the intestinal barrier to iron are alcohol consumption, vitamin preparations with vitamin C, and iron consumed by individuals without anemia. Endogenous generation of excess iron by hemolysis, owing to abnormal hemoglobin or many transfusions, are not controlled by the intestinal barrier.

Ferritins↗