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Biomedical subjects

L G Bongiovanni

Publications and source records attributed to L G Bongiovanni.

28 records · Page 2Linked to original sources
PubMed1988

Congenital muscular dystrophy and cerebellar vermis agenesis in two brothers.

Two brothers with motor retardation since the first months of life presented waddling ataxic-gait with lumbar lordosis, joint contractures and generalized muscle weakness. Both presented altered cerebellar tests and scanning speech. Creatine kinase, electromyography (EMG) and muscle biopsy pointed to muscular disease while CT scanning and NMR imaging showed cerebellar vermis agenesis. On this evidence we diagnosed the unusual association of vermian agenesis and congenital muscular dystrophy.

Atrophy↗
PubMed1986

Local neurotoxicity of cisplatin after intra-arterial chemotherapy.

Acute cranial neuropathy followed intra-arterial chemotherapy with Cisplatin for a squamous cell cancer of the mouth. The favourable course, histological studies and local trophic impairment suggested local neurotoxicity due to Cisplatin accumulation in cranial nerves. The patient was the first to develop such a toxic effect in a series of 35 consecutive patients treated with the same therapy.

Carcinoma, Squamous Cell↗
PubMed1985

Acute peroneal compartmental syndrome. Report of a case.

Among the compartmental syndromes the necrosis of peroneal muscles is unusual. We report a case in which the swelling of peroneal muscle causes a compression of the common peroneal nerve below the peroneal head. A disturbance of both the motility and sensibility of the deep and superficial peroneal nerve is present with different pathogenesis. In fact, EMG suggested a muscular damage of the peroneal compartment and a denervation of the pretibial muscle. Interfascicular neurolysis along the peroneal nerve was performed to decompress the common and the deep peroneal nerve. A recovery in the territory of the tibialis anterior deep peroneal nerve confirmed the different mechanisms of paralysis.

Adult↗
PubMed1983

Serum pyruvate kinase in different neuromuscular diseases and in carriers of muscular dystrophy.

Serum pyruvate kinase and creatine kinase activities were measured in a group of patients with various neuromuscular diseases and in carriers of muscular dystrophy. Elevated values of PK were usually but not invariably associated with elevated levels of CK. THe data showed that PK activity was elevated in all patients with DMD, high values generally correlating inversely with age or disease duration. In definite carriers, the level of PK was raised simultaneously with CK, while in potential carriers, classified by their relationship with MD patients in mothers, sisters and other relatives, the PK levels were elevated in 23%, 44% and 10% respectively, indicating especially for sisters, an increased genetic probability of being a definite carrier. In this way, we have confirmed that the serum PK assay is more sensitive in younger subjects and that combined CK and PK measurement will be of value in detecting a higher proportion of potential carriers.

Adolescent↗
PubMedDate not supplied

Assessment of autonomic functions in insulin-dependent diabetic children and adolescents.

Autonomic function has been studied in 30 insulin-dependent diabetic children and adolescents, through five cardiovascular tests. A significant difference between the diabetic and the control subjects was found in heart rate variations after deep breathing and after standing. Fifty percent of our patients showed an altered response to one or more cardiovascular tests. Although clinical manifestations of autonomic dysfunction are not frequent in young insulin-dependent patients, early signs of functional alterations are detectable in a high percentage of them.

Adolescent↗
PubMedDate not supplied

Multifactorial etiological aspects of epilepsy.

The results of a computerized analysis of 555 newly recognized idiopathic epilepsy patients (301 males and 254 females) are presented. All patients were under 30 years over the period 1980-1985. The possible prenatal and perinatal risk factors (RFs) for epilepsy were investigated. The data showed that 307 patients (55.5%) had possible RFs; 162 had one possible RF, 145 two or more. The association of two or more RFs had a high frequency in secondary generalized epilepsy (66.6%) and in partial epilepsy. A multifactorial etiology of epilepsy is suggested, hypothesizing a connection either between prenatal and perinatal RFs or between multiple perinatal RFs.

Adult↗