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Biomedical subjects

L French

Publications and source records attributed to L French.

78 records · Page 5Linked to original sources
PubMedDate not supplied

The DNA sequence and comparative analysis of human chromosome 20.

The finished sequence of human chromosome 20 comprises 59,187,298 base pairs (bp) and represents 99.4% of the euchromatic DNA. A single contig of 26 megabases (Mb) spans the entire short arm, and five contigs separated by gaps totalling 320 kb span the long arm of this metacentric chromosome. An additional 234,339 bp of sequence has been determined within the pericentromeric region of the long arm. We annotated 727 genes and 168 pseudogenes in the sequence. About 64% of these genes have a 5' and a 3' untranslated region and a complete open reading frame. Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates, the mouse Mus musculus and the puffer fish Tetraodon nigroviridis, provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.

Animals↗
PubMedDate not supplied

Victimization of the mentally ill: an unintended consequence of deinstitutionalization.

Twenty years ago, legal interventions and dramatic advancements in psychopharmacology provided the impetus for a mass exodus from public mental health institutions to community settings. This well-intended move was predicated on the development of a community mental health center network. An unintended consequence, however, is that many deinstitutionalized mentally ill clients have been forced onto the street with little or no treatment. Moreover, a new wave of never treated youth and elderly have joined the street subculture. Without adequate clinical treatment, these people are vulnerable to victimization and to arrest and incarceration. In this article, the history of the problem is reviewed and steps to create a more responsive clinical network to cope with the problem are discussed.

Community Mental Health Services↗
PubMedDate not supplied

How soon is safe? Ambulation of the patient with burns after lower-extremity skin grafting.

Patients with burns of the lower extremity that require skin grafting were randomized into three groups to determine when postgraft ambulation could be safely resumed. Dangling protocol was initiated on postoperative day 6, 8, or 10, and ambulation was started on the next day. Grafts were evaluated at six stages on a five-point scale. In the 22 patients who completed the study, there was no significant difference in scores of the three groups. There was a significant difference in length of hospital stay when patients who dangled on postoperative day 6 were compared with patients who dangled on postoperative day 10.

Adolescent↗