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Biomedical subjects

L Fournier

Publications and source records attributed to L Fournier.

At least 73 records · Page 4Linked to original sources
PubMed1989

High blood lead level in alcoholics: wine vs. beer.

One hundred and sixty one alcoholics (121 men and 40 women) were studied during a social rehabilitation program. All had a daily intake of ethanol higher than 1 g/kg/day. The mean lead blood level was 28 micrograms/100 ml and was as high as 72.5 micrograms/100 ml in one subject. Wine drinkers had a higher blood lead level (29.8 micrograms/100 ml) than beer or spirit drinkers (23.8 micrograms/100 ml). A significant correlation was found between the blood lead level and systolic and diastolic arterial blood pressure and this relation was independent of sex, weight or age. We conclude that a high blood lead level can be a risk factor for hypertension in alcoholics.

Adult↗
PubMed1989

Hyperprolactinemia prevents short photoperiod-induced changes in brown fat.

Previous studies demonstrated that short photoperiod exposure significantly decreases circulating prolactin levels. The present study investigated the possibility that concomitant changes in brown fat tissue mass, protein content, thermogenic capacity, and carcass composition are dependent on this change in prolactin levels. Male golden (Syrian) hamsters were sham operated and exposed to a short (10L:14D) or long (14L:10D) photoperiod. A third group was implanted with exogenous pituitaries under the right kidney capsule and exposed to a short photoperiod. In experiment I, 4 wk of short- vs. long-photoperiod exposure did not result in significant changes in circulating prolactin levels, nor was there an increase in brown fat mass, protein content, or thermogenic capacity. Four weeks of short-photoperiod exposure did significantly increase carcass lipid content. However, this increase did not occur in hamsters exposed to 4 wk of short photoperiod but made hyperprolactinemic (implanted with two exogenous pituitaries). Ten weeks of short photoperiod significantly reduced circulating prolactin levels. Concomitantly, brown fat mass, protein content, and thermogenic capacity, as well as carcass fat, were increased. These short-photoperiod-induced changes were not observed in similarly exposed hamsters that were made hyperprolactinemic via two implanted pituitaries. In experiment II, similar changes in brown fat and body composition occurred in sham-operated hamsters exposed to 10 wk of short photoperiod. These changes were prevented in hamsters exposed to 10 wk of short photoperiod but made hyperprolactinemic via only one implanted pituitary. These results suggest that decreased prolactin is a necessary condition for the increased brown fat mass, protein content, and thermogenic capacity that occurs when golden hamsters are exposed to short photoperiod.

Adipose Tissue, Brown↗
PubMed1989

[Congenital diaphragmatic hernia. Therapeutic re-evaluation].

Twenty-eight patients with "High-Risk" diaphragmatic hernia were treated without postoperative ipsilateral chest drains. Overall survival was 71%. This study suggests that, in cases of complete absence of the diaphragm, the use of a mesh pervious to air is as noxious postoperatively as an underwater chest drain. This idea is supported by experiments in cats with a left pneumonectomy, in which part of the diaphragm was replaced either by a macroporous mesh or by a microporous prosthesis impervious to air at normal pressures. Moreover, barotrauma may occur preoperatively and when assisted ventilation is required, inspiratory pressure must be strictly limited.

Animals↗
PubMed1988

[A method of bacterial count by epifluorescence with acridine orange. Application to skin biopsies performed in burnt patients].

Acridine orange was used for staining and counting micro-organisms obtained from 136 skin biopsies performed in burned patients. The number of organisms per gram of tissue was compared to the number of colony-forming-units (CFU) calculated from cultures of the same biopsies. The staining method was positive in 97 per cent of septic samples, and in 25 per cent of these it proved more sensitive than bacterial cultures, with a 100 to 1000-fold greater number of pathogens detected. Acridine orange also demonstrated bacteria in 69 biopsies which remained sterile after culture. In some cases, the same bacterial species was found in other samples taken a few days later.

Acridine Orange↗
PubMed1987

Pulmonary barotrauma in congenital diaphragmatic hernia: experimental study in lambs.

A left diaphragmatic hernia was created surgically in 20 fetal lambs between 93 and 110 days of gestation. Ten animals were alive with defects at cesarean section near term (135 to 140 days). These animals and two controls were submitted to various transpulmonary pressure gradients (inspiratory pressure minus pleural pressure). Hemodynamic and ventilatory studies were performed after the correction of the hernia. Morphometric analysis of the lung was carried out in all cases. The results showed a highly significant linear correlation between the transpulmonary pressure gradient employed and the pulmonary interstitial emphysema found at morphometry. Our data suggest that using low ventilatory pressures and not draining the pleural cavity results in less trauma to both lungs and may prevent one of the components of the pulmonary hypertension so often seen in newborns with congenital diaphragmatic hernia.

Animals↗
PubMed1987

[Determination of the neurotoxic esterase in neurologic pathology of toxic origin. Measurement in human lymphocytes in poisoning by organophosphates, ciguatera and ethyl alcohol].

Lymphocytic NTE activity was measured after intoxication by organo phosphorus compounds and in chronic alcoholics at the beginning of alcohol withdrawal. The results showed a rapid fall in lymphocytic NTE activity; neuropathy developed when the inhibition was 75 p. 100 or more. In chronic alcoholics, the fall in NTE activity is a new concept which must be taken into account when considering the causal factors of neurotoxicity in exposed professions and in patients taking potentially neurotoxic drugs. The NTE may be a useful parameter to demonstrate the toxic origin of chronic neuropathies, especially those caused by drugs. The capacity for lymphocytic NTE activity to return to normal seems to be different in acute, compared with chronic, intoxications.

Acute Disease↗
PubMed1986

Diagnosis of systemic candidiasis: application of co-counterimmunoelectrophoresis.

The accuracy of co-counterimmunoelectrophoresis was compared with mycological and clinical data for different groups of inpatients. The specificity and sensitivity of this method ranged from 100 to 69%. The co-specific precipitin line was observed during systemic infections caused by most opportunistic Candida species. The variations in the line in successive serum samples provided a simple means of serological surveillance. The test also detected seroconversion. The gradual disappearance of the line reflected a favourable prognosis, whereas its abrupt disappearance indicated unfavourable prognosis and correlated with the appearance of detectable circulating antigens.

Adult↗
PubMed1986

In vivo survival of red blood cells processed by a bubble or membrane oxygenator during cardiopulmonary bypass surgery.

A dual radioisotope labeling technique was utilized to assess red cell survival differences between cells processed by either a bubble oxygenator (eight patients) or membrane oxygenator (eight patients) in 16 patients undergoing cardiopulmonary bypass surgery. Cells processed by a bubble oxygenator consistently had a shortened survival. The 30-minute recovery of cells was not significantly different between oxygenators in contradiction to some previous studies using plasma hemoglobin as an indicator of hemolysis. The results of this investigation confirm previous studies that a membrane oxygenator provides a survival advantage to red cells during cardiopulmonary bypass surgery.

Journal Article↗
PubMed1986

[Application of a co-electrosyneresis reaction to the diagnosis and serological surveillance of candidiasis in a hospital milieu].

We have previously described a co-immunofiltration reaction which identifies a specific precipitating system (SPCS) in sera from patients presenting systemic candidiasis. The SPCS is characterized by coalescence with an experimental serum directed against the germinative tubes of Candida albicans. The present study concerns our experience of the use of co-immunofiltration in routine hospital practice. Complete observations involving clinical, mycological and serologic data were selected in order to illustrate various possible developmental trends for SPCS during candidiasis. The SPCS usually develops early infections due to the yeast species most frequently implicated in hospital pathologies; an increase in its intensity reflects a developing infection or the start of therapy. The SPCS disappears slowly and gradually when infectious development is favorable, but its sudden disappearance represents an unfavorable prognosis correlated with detection of circulating antigens. Circulating antigens are also seen in severe cases of candidiasis in which the SPCS is not present. Indeed there is a certain complementarity between these two observations.

Antibody Formation↗
PubMed1985

A comparative analysis of newborn outcome in a hospital-based birthing center.

Medical records of babies born in a hospital-based birthing center were reviewed to determine whether a birthing center alternative to traditional hospital care of the newborn is safe and cost-effective. A cohort of 123 hospital-based birthing center low-risk deliveries was compared to 100 control low-risk deliveries born in the traditional setting at the medical center during the same time period. Morbidity was assessed using the Hollister Classification as reference and was based on treatment need. The analysis of the babies' status at birth, 24 hours, and 72 hours revealed no difference in immediate morbidity. Cost of hospitalization was reduced by $340.00 per cohort baby. These data suggest that this alternative can be safe and cost-effective. This study applies only to hospital-based birthing centers, because the safety of free-standing birthing centers has not been established and because screening for low risk can not eliminate morbidity.

Adult↗