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Biomedical subjects

L Foster

Publications and source records attributed to L Foster.

5 recordsLinked to original sources
PubMed1992

Molecular analysis of carbohydrate antigen-induced monoclonal IgM anti-IgG antibodies (rheumatoid factors).

Light and heavy chain variable regions of 11 monoclonal rheumatoid factors (MRF) produced after carbohydrate antigen immunization, and one MRF produced after protein immunization have been sequenced. Most carbohydrate antigen induced MRF utilized light chains that were homologous to light chains of MRF obtained from protein immune or LPS stimulated mice, and MRF derived from the autoimmune MRL/lpr mouse strain. VH gene usage was diverse for carbohydrate antigen induced MRF that bound all four isotypes of IgG, or that bound only the IgG3 isotype. In contrast VH gene use among our panel of MRF that bound the IgG1 isotype appeared restricted. Four of the five IgG1 binders used VH genes that were highly homologous to the VH nucleotide sequence of a gene encoding an NP binding monoclonal antibody. Our study confirms the use of a particular group of light chain genes among murine MRF, confirms that there is diversity in the heavy chain genes utilized among MRF, and suggests that a gene(s) homologous to the VH NP 23 J558 gene may be preferentially associated with murine MRF specificity for the IgG1 isotype.

Amino Acid Sequence↗
PubMed1978

Thyroid function tests in elderly hyperthyroid patients.

Several tests of thyroid function were performed in 35 hyperthyroid patients over the age of 65 (elderly). The results were compared to those of similar tests in 48 hyperthyroid patients under the age of 65 (young). Total serum thyroxine (T4) was within the normal range in 14 percent of the elderly and 11 percent of the young hyperthyroid patients. The free thyroxine index (FTI) was within the normal range in 11 percent of both groups. The triiodothyronine uptake (T3U) proved to be a poor test in both groups. Although elevation of the triiodothyronine (T3) level allowed a diagnosis of "T3-toxicosis" in 2 elderly and 3 young hyperthyroid patients, the T3 level was normal in 34 percent of the elderly and 13 percent of the young subjects. Correction of the T3 range for age reduced the number of normal T3 values to 12.5 percent in the elderly hyperthyroid patients. The 24-hour uptake of radioactive iodine was normal in 12 percent of the young hyperthyroid patients, 27 percent of the elderly patients with Graves' disease, and 70 percent of the elderly patients with toxic nodular goiter, despite recent readjustment of the normal range for the test. It is concluded that the diagnosis of hyperthyroidism in the elderly may be difficult and that no single test can be relied upon to exclude the diagnosis.

Adult↗
PubMed1975

Carcinoembryonic antigen-positive metastatic adenocarcinoma of the choroid. A case report.

Plasma carcinoembryonic antigen (CEA) levels were found to be elevated in a 62-year-old woman who came to us with a diffuse choroidal mass in the left eye. Although a metastatic tumor was suspected clinically, a thorough medical evaluation failed to detect a primary lesion and the eye was enucleated. The histologic diagnosis was metastatic adenocarcinoma. On immunohistologic assay, the choridal metastases stained positively for CEA. We believe this to be the first CEA-positive intraocular tumor to be reported.

Adenocarcinoma↗