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L Fontana

Publications and source records attributed to L Fontana.

185 records · Page 11Linked to original sources
PubMedDate not supplied

[CoQ10 blood levels and erythrocyte concentration of GSH in ischemic heart patients during exercise test (effects of vitamin E)].

During exercise there is an increase of oxygen consumption with production of superoxide anion. Tocopherols and ubiquinones are intrinsic lipid components involved in antioxidant protection and also glutathione reduced is an important water soluble antioxidant. The authors take into consideration 28 patients with ischemic heart disease coming in a rehabilitation center. In a group of 14 of them we studied the effects on the exercise ergonometer test of administration of 1200 mg of tocopherol on the behaviour of ubiquinone plasmatic levels and GSH. In this group CoQ10 after exercise increase significantly (0.762 SD 0.134 g/ml before vs 0.827 SD 0.89 after). GSH doesn't increase after (2.5 SD 0.459 mM/l vs 2.492 SD 0.457). In the group of patients without tocopherol after exercise CoQ10 decrease significantly (-39%) and also GSH has the same behaviour (-15%). Our study shows that the administration of tocopherol prevents lipoperoxidation occurring during exercise test.

Adult↗
PubMedDate not supplied

Prophylaxis in transurethral surgery: oral lomefloxacin versus intravenous cefuroxime.

A randomized study compared the efficacy of a single dose of lomefloxacin given orally vs. cefuroxime given intravenously for prophylaxis against urinary tract infection in patients who were undergoing transurethral surgery. Patient groups were demographically similar; 25 received 400 mg lomefloxacin orally 2-6 h before surgery and 26 received 1.5 g cefuroxime intravenously 30-90 min before surgery. Urine cultures were obtained prior to surgery, 24 h after surgery and 3-5 days after surgery or before hospital discharge. Treatment was considered successful if bacterial culture showed < 10(5) CFU/ml. Clinical results expressed as success/failure rates showed success in 18 patients in the lomefloxacin group (72%) and 15 patients in the cefuroxime group (57.7%). Results demonstrated that lomefloxacin is superior to cefuroxime when used as prophylaxis against urinary tract infection following transurethral surgery. In addition, lomefloxacin may be preferable because of its convenient single-dose oral administration.

Administration, Oral↗