Rats fed tryptophan-poor corn diets have reduced levels of brain serotonin and show increased responsiveness to electric shock. This diet-induced hyperalgesia can be reversed by feeding the animals diets with adequate amounts of tryptophan, or by systemic injections of the amino acid.

Animals↗

PubMed1975

Quinidine plasma concentration and exertional arrhythmia.

Quinidine gluconate was used to treat arrhythmia induced with maximal exercise testing. Twenty-nine subjects who had previously developed frequent premature contractions on testing were selected for further study. After a control maximal exercise test, quinidine (10 mg. per kilogram) in solution was given orally in a single dose, and two hours later the same test was repeated. Recurrence of premature contractions was completely prevented in five of the 19 subjects tested; suppression was better than the mean value in three others, and in 11 subjects it was below the mean value. The plasma concentration at two hours was 1.68 plus or minus 0.31 ug per milliliter, which is a therapeutic level. Raising the dose to 15 mg. per kilogram eliminated the premautre contractions in six subjects whose response to 10 mg. per kilogram had not been complete, but not in two others. Lowering the dose to 5mg. per kilogram lowered the plasma level to below the therapeutic level. No differences between the responses to the drug of the otherwise healthy subject and those with symptomatic heart disease could be found. Compared with the responses to the control tests, there were small but significant changes in the second test in heart rates, blood pressure, and duration of exercise. Aerobic working capacity estimated by Vo2max was unchanged. Mild toxic effects manifested by malaise and diarrhea were a common finding with both 10mg per kilogram and 15mg per kilogram of quinidine, but not with 5mg per kilogram.

Administration, Oral↗

PubMed1975

Stability and change in strategies of psychiatric patients and normal interviewees.

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Adult↗

PubMed1975

Puromycin effect on amino acid transport: differential rates of carrier protein turnover.

In fetal rat calvaria, puromycin selectively inhibited the uptake of certain groups of amino acids. Puromycin treatment decreased the uptake of glycine, L-proline, and alpha-aminoisobutyric acid but was without effect on the active uptake of all other amino acids tested. In studies of alpha-aminoisobutyric acid uptake, puromycin decreased the maximal transport velocity by 70% but had no effect on the affinity of the transport system for the amino acid. With puromycin treatment, the fall-off in rates of alpha-aminoisobutyric acid uptake was first order with a half-life of 68 min. Insulin treatment increased this half-life to 118 min. These findings suggest that protein components of specific transport systems are degraded at varying rates after puromycin blockade of protein synthesis. Hormones that stimulate amino acid transport (e.g., insulin) may decrease the rate of degradation of these protein components.

Amino Acids↗

PubMed1975

Developmental aspects of auditory and visual scanning.

60 Ss from Grades 1 through 6 were administered an auditory and visual scanning procedure and 27 of those Ss were given arithmetic and reading achievement tests. Data indicated scanning ability increases linearly with grade in school and the relationship between the scanning measures also increases sharply with grade. Auditory scanning was related to academic achievement; visual scanning only approached significance with arithmetic achievement but was unrelated to reading achievement.

Achievement↗

PubMed1975

Sensory integration and single-modality scanning.

An auditory scanning, visual scanning, and auditory-visual integration test was administered to 72 children from grades 1, 2, 3, and 5 to determine whether increases in sensory integration skills could be accounted for by increases in skills of single modalities. Using a multiple regression model, the results indicated that increases in integrative functioning occur independently of developmental changes in individual modalities. Implications for future research are presented.

Auditory Perception↗

PubMed1975