Organic disulfides and related substances. 33. Sodium 4-(2-acetamidoethyldithio)butanesulfinate and related compounds as antiradiation drugs.
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Biomedical subjects
Publications and source records attributed to L Field.
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This article presents an empirical study of nurses' and patients' assessment of patients' pain following surgery. The study aimed to replicate and extend previous research which indicated that nurses tend to underestimate patients' pain. The independent variables were type of operation, patient gender, time since surgery and nurses' experience. Results confirmed that nurses give consistently lower pain ratings than patients. The prediction that nurses' pain ratings would be influenced by the type of operation was not confirmed. Not surprisingly, pain ratings were lower on day four than on day one. The data failed to confirm previous findings that the more junior the nurses the greater pain they infer in their patients. The main conclusion of this research is that nurses continue to underestimate the severity of pain suffered by patients postoperatively.
The first article in this two-part series (Vol 5(13): 778-84) presented an empirical study of nurses' and patients' pain following surgery. Results indicate that nurses give consistently lower pain ratings for patient's pain than do patients. The main implication of this research is that nurses continue to underestimate the severity of pain suffered by patients postoperatively. This article considers a second empirical study, the objectives of which were to determine which methods nurses use to assess and monitor pain relief and which factors influence their decision to give or withhold analgesia. Results reveal that while nurses claim to rely on patients' self-reports of pain, the most influential factors in the decision whether or not to give analgesia are the dosage, type and frequency of drug prescribed. The main reason for withholding analgesia is that the patient reacted adversely to the medication. Student nurses placed more emphasis than trained nurses on the timing and amount of analgesia given. Nurses had a good knowledge of pain assessment tools, although few had used them.
The administration of dimethyl sulfoxide with cisplatin at a mole ratio of 200:1 results in a considerable reduction in the nephrotoxicity produced when cisplatin alone is administered to Sprague-Dawley rats at 7.5 mg/kg. Observed measures of nephrotoxicity which were significantly improved by the coadministration of cisplatin and DMSO over the values found for cisplatin alone include BUN, serum creatinine, creatinine clearance and histopathological evidence of renal damage. The weight loss associated with cisplatin administration was also significantly reduced by DMSO coadministration. The use of DMSO did not result in any observable loss in antitumor activity of cisplatin against the Walker 256 carcinosarcoma.