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Biomedical subjects

L Feuer

Publications and source records attributed to L Feuer.

At least 37 records · Page 2Linked to original sources
PubMed1981

Experimental studies on the cardiological effects of ipriflavone on the isolated rabbit heart and in rat and dog.

7-Isopropoxy-isoflavone (Ipriflavone) treatment of rabbits for 8 days at daily oral doses of 30 mg/kg significantly decreases the oxygen consumption of their isolated hearts. In anoxia this effect is more pronounced. 10-day oral treatment of rabbits with 10 or 20 mg/kg/day of ipriflavone led to a significant decrease of the lactic acid content in the myocardium, especially, in the ischaemic region. A 6-day oral pre-treatment of rats with 30 mg/kg/day of ipriflavone significantly decreases the coronary ligation-induced damage of the mitochondria and myofibrils. Electron microscope autoradiography shows that ipriflavone significantly counteracts the coronary ligation induced calcium accumulation in the mitochondria. Ipriflavone seems to influence the mitochondrial energetics in a positive manner. It has an oxygen sparing effect.

Animals↗
PubMed1980

Effect of parathyroid extract and of glutaurine (gamma-L-glutamyl-taurine) on the manifestations of osteolathyrism.

BAPN-induced osteolathyrism in young and older male rats was examined for its responses to parathormone-free, gel-filtered bovine parathyroid extract (extract P) and to glutaurine (gamma-L-glutamyl-taurine), the latter being a hitherto unknown putative hormone isolated from bovine parathyroid and reproduced by synthesis. In case of the daily administration of 20 mg BAPN + 0.2 mg extract P/100 g body weight and of 40 mg BAPN + 0.2 micrograms glutaurine/100 g body weight, both substances were found to attenuate the manifestations of osteolathyrism, to a significant extent, without, however preventing their development completely. The significantly decreased Ca, P, chondroitine sulphate and chrondroprotein values due to the administration of BAPN showed a significant, or highly significant, increase for the cartilage in response to extract P, and for both cartilage and bone in response to glutaurine, without however, attaining the control values. Additional evidence has been furnished by the present study that synthetic glutaurine is equal to the parathormone-free, gel-filtered parathyroid extract (extract P) in its attenuating effect on experimental osteolathyrism.

Aminopropionitrile↗
PubMed1980

Synthesis of gamma-L-glutamyl-taurine.

Glu(Tau), a bioactive substance previously isolated from the protein free aqueous extract of bovine parathyroid powder, has been synthesized. The intermediate derivative Z-Glu(Tau)-OBzl was prepared in three different ways from Z-Glu-OBzl and (1) cystamine by using the mixed anhydride method followed by oxidation, (2) Tau by the active ester procedure via Z-Glu-(ONp)-OBzl, (3) Tau applying mixed anhydride coupling. The protecting groups were removed by hydrogenolysis.

Animals↗
PubMed1980

Effect of litoralon (gamma-L-glutamyl-taurine) on the tail involution of tadpoles in vitro.

Litoralon (gamma-L-glutamyl-taurine), a newly discovered hormone of the parathyroid increases the involution of the explanted tail tip of Rana arvalis tadpoles in vitro, while it antagonizes significantly the similar effect of triiodothyronine. This finding, in accordance with the results of earlier in vivo experiments, implies a direct effect of Litoralon on the target tissues.

Animals↗
PubMed1980

Complex morphological study of the effect of glutaurine in mast cells.

Glutaurine produces rapid and intensive degranulation of mast cells without affecting the composition of their granules. The mast cells of the individual organs differ in the type and extent of degranulation. There is a wide scale between excessive degranulation (mast cells of subcutaneous connective tissue and of the peritoneum), and unresponsiveness (mast cells of thyroid and lymph nodes), and there are also differences in time. The peritoneal mast cells stain positively with safranin, swell excessively and assume bizarre forms in response to 5 micrograms/rat glutaurine intraperitoneally. Frequent occurrence of lymphocyte-mast cell contacts seems typical. Glutaurine increases 3H-histidine uptake of the peritoneal fluid cells in general and 35S sulphate incorporation in the peritoneal mast cells in particular. Accumulation of these substances is more marked at 1 hour than at 3 hours after application.

Animals↗
PubMed1980

Effect of glutaurine on the pineal gland of the rat.

Glutaurine (gamma-L-glutamyl-taurine), the recently discovered hormone of the parathyroid enhances the aggregation and subsequent degeneration of mitochondria in the pinealocyte processes of the rat pineal gland. It also stimulates autophagy, probably through its general lysosome activating effect.

Animals↗
PubMed1979

Radioprotective effect of a protein free parathyroid extract on the mitotic index of rat bone marrow cells.

The protective efficacy of an orally administered bovine protein-free parathyroid extract (PF-PTE) was studied on rat bone marrow cells in vivo with the mitotic index after 850 R irradiation. A remarkable decrease was found in the mitotic activity of bone marrow cells after irradiation in the non-protected animals. However, in the animals treated with PF-PTE after irradiation, a significantly smaller decrease and a faster recovery were found in the mitotic activity of the bone marrow cells.

Animals↗
PubMed1979

Analysis of the antagonistic effect of gamma-L-glutamyl-taurine on glucocorticoid and triiodothyronine.

gamma-L-Glutamyl-taurine, a newly discovered parathyroid hormone, considerably inhibited the cytochemically detected transcription-inducing effect (appearance of free histone) of prednisolone and triiodothyronine. Such an inhibition took place also if the morphogenetic hormones were given not simultaneously with, but after the administration of litoralon. Litoralon injected alone also displayed inductor properties increasing the number of nuclei containing free histone.

Animals↗
PubMed1979

The triiodothyronine antagonistic effect of gamma-L-glutamyl-taurine (litoralon).

A recently recognized bioactive substance of the parathyroid glands, gamma-L-glutamyl-taurine antagonises the metamorphosis enhancing effect of triiodothyronine. Shortening of the body-length of tadpoles is significantly delayed by the substance. The experimental results imply that it fulfills the role of a balance hormone.

Animals↗
PubMed1978

Radioprotective effect of a protein free parathyroid extract.

The radioprotective effect of a bovine protein-free parathyroid extract was studied in rats, being administered orally after irradiation. A significant increase in survival was found after treatment compared to conrols. It is assumed that the extract contains a new, probably as yet unknown bioactive agent responsible for the radioprotection.

Animals↗