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Biomedical subjects

L Fernandez-Herlihy

Publications and source records attributed to L Fernandez-Herlihy.

17 recordsLinked to original sources

Temporal arteritis: clinical aids to diagnosis.

From 1982 through 1987, 107 patients underwent temporal artery biopsy at the Lahey Clinic. In 29 patients, biopsy revealed temporal arteritis (TA). These patients had appreciably more jaw claudication, anemia, anorexia and a higher erythrocyte sedimentation rate (ESR) than patients whose temporal artery biopsy revealed negative findings. Certain clinical criteria and symptom clusters, which include jaw claudication, are highly specific for positive results on temporal artery biopsy. Length of arterial segment examined and previous corticosteroid therapy did not influence the results of temporal artery biopsy. TA should be confirmed histologically whenever possible. When results of biopsy are negative, patients fulfilling clinical criteria or having symptom clusters specific for TA should receive steroid treatment.

Aged↗

Arthritis after jejunoileostomy for intractable obesity.

Joint symptoms developed in six of 33 patients (18%) who had jejunoileostomy as treatment for intractable obesity. These consisted of single or recurrent attacks of polyarthritis or arthralgias, primarily in large joints. The histocompatibility antigen, HL-A B27, was not present in these patients. Most attacks responded to simple analgesic agents, but a trial of tetracycline in one patient failed to relieve joint symptoms. This arthropathy seems to differ from that which has been reported after jejunocolostomy.

Adult↗

Duration of corticosteroid therapy in giant cell arteritis.

A follow-up study of 29 patients with giant cell arteritis (GCA) was undertaken to determine the duration of corticosteroid treatment. In 20 patients the diagnosis was confirmed by biopsy of a temporal artery (Group 1). In 9 patients GCA was evident clinically (Group 2). Treatment was continued until reductions in corticosteroid dosage no longer resulted in clinical evidence of GCA. The mean duration of corticosteroid treatment was 6 yr. The diagnosis of GCA should be confirmed by means of a temporal artery biopsy before treatment is begun because it may commit the patient to years of corticosteroid treatment.

Aged↗