Biomedical subjects
L F Prescott
Publications and source records attributed to L F Prescott.
Pharmacokinetic drug interactions.
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The effects of repeated administration of mercuric chloride on exfoliation of renal tubular cells and urinary glutamic-oxaloacetic transaminase activity in the rat.
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Renal papillary necrosis and aspirin.
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Frusemide and urinary cell loss.
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Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide.
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The effect of cephaloridine on renal tubular cell excretion.
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Analgesic abuse and renal disease in North-East Scotland.
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Liver damage and impaired glucose tolerance after paracetamol overdosage.
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The nephrotoxicity of analgesics.
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Combined clinical and metabolic study of the effects of alpha-methyldopa on hypertensive patients.
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The normal urinary excretion rates of renal tubular cells, leucocytes and red blood cells.
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The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney.
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The metabolism of phenacetin in patients with enal diseas.
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The effects of particle size on the absorption of phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system.
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The clinical significance and importance of drug interactions.
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Fulminant hyperkalaemia and multiple complications following ibuprofen overdose.
A previously healthy 17-year-old man was admitted in coma following major overdosage with ibuprofen and minor overdosage of doxepin (plasma concentrations 809 and 0.49 mg/L, respectively). Initially, potassium chloride (20 mmol 3-hourly) was infused because of mild hypokalaemia (K+ 2.8 mmol/L). 14 hours after admission the patient developed a hypermetabolic state with pyrexia, metabolic acidosis and progressive respiratory failure despite ventilation at 16 L/min, and a malignant broad complex tachycardia was associated with acute hyperkalaemia (K+ 8.3 mmol/L). The arrhythmia resolved with correction of the hyperkalaemia. Chest x-rays showed diffuse opacification throughout both lung fields and subsequently there was transient impairment of renal function, with evidence of mild rhabdomyolysis. Ventilatory support was required for 60 hours and a chest x-ray at 6 days showed extensive bilateral nodular shadowing, which was still present at follow-up 4 weeks later.