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Biomedical subjects

L F Martin

Publications and source records attributed to L F Martin.

121 records · Page 7Linked to original sources
PubMedDate not supplied

Elevation of renal glutathione enhances ischemic injury.

In a previous study, we tested the hypothesis that an elevated level of renal glutathione (GSH) would protect the kidney from ischemic injury. However, prior elevation of GSH with GSH monoethylester enhanced then injury induced by 35 min of ischemia and blood reflow [Scaduto RC Jr, Gattone VH, Grotyohann LW, et al; Effect of an altered glutathione content on renal ischemic injury. Am J Physiol 1988;255:F911-F921]. Additionally, GSH monoethylester produced morphologic alterations in the absence of ischemia. Thus the greater ischemic injury observed after GSH ester pretreatment could have been due to a synergistic effect between the events caused by ischemia and the pretreatment. The present study was conducted to evaluate the utility of elevating renal GSH levels by administration of GSH. Administration of GSH (1 mmol/kg body weight) caused a 3-fold elevation of renal GSH levels and a 6-fold elevation of renal cysteine levels after 60 min without causing changes in renal morphology or GFR. After 35 min of renal artery occlusion and 90 min of blood reflow, animals pretreated with GSH had a much greater decline in GFR than untreated control animals. This enhancement of renal ischemic injury in GSH-treated animals was similar to that observed following administration of GSH monoethylester. We conclude that administration of GSH is the method of choice for elevation of renal GSH and that elevation of renal GSH leads to an enhanced ischemia-induced injury which is independent of the method employed to elevate renal GSH.

Adenine Nucleotides↗
PubMedDate not supplied

A multiple-channel cochlear implant and wearable speech-processor: an audiological evaluation.

Stand audiological tests were administered to a totally deaf multiple-channel cochlear implant patient with a wearable speech-processor in a monitored sound field under the following conditions: a wearable unit activated alone (WA), lipreading with the wearable unit off (LA), and wearable unit activated in combination with lipreading (WL). Thresholds obtained for narrow-band noise signals indicated that the wearable unit allowed the patient to detect a variety of sounds at different frequencies. The results obtained in closed-set word tests and open-set word and sentence tests showed significant improvements in word and sentence scores from LA to WL. In the open-set (C.I.D.) sentence test, the patient scored 22% for LA and 76% for WL. The WL score of 76% correlates with a satisfactory performance in understanding connected speech. The patient also scored 30% correct in a test involving the recognition of environmental sounds.

Cochlear Implants↗
PubMedDate not supplied

A multiple-channel cochlear implant. An evaluation using an open-set word test.

Multiple-channel electrical stimulation of the hearing nerve in conjunction with speechreading has helped two post-lingually deaf patients with total hearing losses understand running speech in every day situations. This has been confirmed using open-set phonetically balanced word tests, where the patients achieved 60% and 40% scores with isolated-words, and 80% and 73% for phonemes-in-isolated words. The tests also showed that the cochlear implant improved word recognition by a factor of four in one patient and two in another, compared with speechreading alone. The speech processor used, extracted the voicing frequency and energy, and the frequency and energy of the dominant spectral peak in the mid-frequency range. The parameters for voicing determined the rate of stimulation for all electrodes, and the parameters for the dominant spectral peak in the mid-frequency range determined the site of electrode stimulation and current level.

Cochlear Implants↗
PubMedDate not supplied

Results of a preliminary clinical trial on a multiple channel cochlear prosthesis.

Speech discrimination testing was carried out under clinical trial conditions for eight profoundly postlingually deaf adults to assess the efficacy of a newly developed 22-channel cochlear prosthesis and speech processor. Three months postoperatively, these patients showed significantly better results with the cochlear prosthesis than for preoperative testing with a conventional hearing aid or vibrotactile aid (following a 6-month trial with the aid) on each of a series of tests from the Minimal Auditory Capabilities battery. Assessment of lipreading enhancement using standard speech tests, consonant recognition studies, and speech tracking showed significant improvements for each patient when using the cochlear prosthesis. Six patients showed a significant amount of open set speech discrimination without lipreading at levels which have not been reported for single electrode cochlear prostheses. The two patients who performed poorly on these tests both had restricted multiple channel systems due to their disease, one patient being restricted to virtually a single channel system and the other to only ten of the 22 electrodes. These results indicate that this multiple channel cochlear prosthesis has potential as a treatment for profound postlingual deafness over a wide range of etiologies and ages.

Adult↗