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Biomedical subjects

L Eriksen

Publications and source records attributed to L Eriksen.

At least 109 records · Page 6Linked to original sources
PubMed1978

Urinary excretion of porphyrins in two cases of porphyria cutanea tarda during a period of various treatments.

The urinary excretion of porphyrins in two cases of porphyria cutanea tarda (PCT) has been followed during a period in which various treatments have been tried. In one patient pyridoxal-5-phosphate (P-5-P) injections lead to a dramatic increase in porphyrin excretion. In another P-5-P treatment was followed by a significant decrease in porphyrin excretion. p-Aminobenzoic acid (PABA) apparently had no effect on porphyrin excretion, while repeated phlebotomies had the expected effect. In both patients all variations in the total amount of porphyrins excreted were almost exclusively due to the variations in the amounts of heptacarboxylic porphyrin type III and uroporphyrin I. A secondary finding was an increase in hexa- and penta-carboxylic porphyrins type III without a concomitant increase in coproporphyrin III.

4-Aminobenzoic Acid↗
PubMed1977

Urinary excretion of position isomers of penta-and hexa-carboxylated porphyrins belonging to the isomer III series in a case of congenital erythropoietic porphyria.

The excretion of position isomers of penta- and hexa-carboxylated porphyrins type III in the urine in a case of congenital erythropoietic porphyria characterized by the excretion of large amounts of penta-, hexa- and hepta-carboxylated porphyrins type III together with isocoproporphyrins both in the urine and faeces, and a simple method for the synthesis and separation of such position isomers has been described. The implications of the finding of position isomers type III have been discussed and it is suggested that the decarboxylation of uroporphyrinogen III both in the present case and under physiological conditions is a random process.

Chromatography, Paper↗
PubMed1977

A study of blood eosinophil counting in calves.

Blood eosinophils were determined in eight 7--13-month-old calves that had been reared under parasite-free conditions. Eosinophil counts were obtained by three methods, a) a direct count, b) a differential count and c) an indirect count (i.e. differential count x total leucocyte count). Methodological errors of these methods were determined. Upper limits of 1,000 eosinophils/micronl (direct count) and 9.5 per cent eosinophils (differential count) have been estimated an suitable working standards for calves of this age group. The distribution of eosinophils was skew, most direct counts being below 700 cells/micronl and most differential counts being below 7.5 per cent. A high degree of correlation was found between results obtained by either method, but an even higher correlation was found between direct and indirect counts.

Age Factors↗
PubMed1975

Oral retinoic acid as therapy for congenital ichthyosiform erythroderma.

Oral retinoic acid has been therapeutically beneficial for three patients with congenital ichthyosiform erythroderma and one with congenital bullous ichthyosifrom erythroderma. Response to therapy was slow but definite with suppression of scale formation, marked reduction of painful cracking of the underlying epidermis and disappearance of skin irritation. Side effects have not occurred. Therapy had to be maintained to prevent recurrence of symptoms.

Administration, Oral↗
PubMed1975

The effect of various therapeutic trials on the prophyrin excretion in a case of congenital erythropoietic prophyria.

A patient with a biochemically "new" type of congenital erythropoietic porphyria has been studied under various therapeutic trials. Splenectomy had no demonstrable effect on porphyrin excretion or clinical picture. Vitamin E caused a moderate fall in porphyrin excretion, however, there was no significant improvement in light tolerance and tendency to hemolysis. Beta-carotene reduced skin photosensitivity appreciably, while total porphyrin excretion remained unchanged and the tendency to develop hemolytic anemia showed only slight improvement. Red cell transfusion caused a rapid, dramatic fall in prophyrin excretion (in 4-5 days) and a transient increase in light tolerance, while the distribution of the different porphyrins excreted remained unchanged. These observations indicate that all or nearly the abnormal porphyrins excreted are of erythropoietic origin, and that the overwhelming part of the porphyrins originate from an abnormal population of shortlived red cells. Findings on fluorescence microscopy of blood and bone marrow support this view. Meticulous protection against light of the shorter wavelengths caused a similar rise in hemoglobin level as produced by red cell transfusion, however, in this instance the total excretion of porphyrins did not fall. It is suggested that the inhibitory effect of transfusion on erythropoiesis (and thereby porphyrin excretion) might be due partly to a depression of erythropoietin formation, partly to the presence of an erythropoiesis inhibiting factor (chalone) in the transfused red cells.

Blood Transfusion↗