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Biomedical subjects

L Eisenbud

Publications and source records attributed to L Eisenbud.

At least 19 recordsLinked to original sources
PubMed1989

Chronic mucocutaneous candidiasis-thymoma syndrome. A case report.

A 69-year-old woman sought treatment with a history of persistent debilitating intraoral ulcerations and recurrent oral and vaginal candidiasis. The medical history included thymoma, breast cancer, and lip cancer. The oral lesions were consistent with bullous lichen planus. Laboratory studies showed severe hypogammaglobulinemia. The chronic mucocutaneous candidiasis-thymoma syndrome is now recognized as a distinct form of primary immunodeficiency.

Aged↗
PubMed1988

Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases.

This report reviews experiences in the management of 37 cases of central giant cell granuloma of the jaws. The statistical analysis includes location, age, sex, size on initial presentation, and other variables relating to incidence and distribution. The technique of curettage or curettage with peripheral ostectomy was used in all cases treated surgically, resulting in no evidence of disease in 21 out of 23 cases followed postoperatively for 2 or more years. Radiation therapy was curative in one instance. Preoperative endodontic therapy for teeth in the field of surgery has proved to be advantageous. The pathogenesis of the giant cell granuloma of the jaws is discussed.

Adolescent↗
PubMed1988

Spatial patterns in the fruiting bodies of the cellular slime mold Polysphondylium pallidum.

During morphogenesis in the slime mold Polysphondylium pallidum cell masses are periodically pinched off from the base of the developing sorogen. These masses round up and differentiate into secondary sorogens, which become radially ordered arrays of secondary fruiting bodies called whorls. Here we describe the morphogenesis of P. pallidum and characterize the spacing of whorls along the central stalk of the fruiting body and the spacing of sorocarps within whorls. We find both are highly regular. We propose that the linear spacing of whorls can be accounted for satisfactorily by a model that views the periodic release of cell masses from the base of the developing sorogen as the consequence of an imbalance between forces that orient amoebae toward the tip of the culminating sorogen, and cohesive forces between randomly moving cells in the basal region of the sorogen, which act as a retarding force. The orderly arrangement of fruiting bodies within whorls can be explained most easily by models that employ short-range activation and lateral inhibition.

Cell Differentiation↗
PubMed1987

Recurrent aphthous stomatitis of the Behçet's type: successful treatment with thalidomide.

A 48-year-old man with a 27-year history of debilitating recurrent aphthous stomatitis major and pustular skin lesions was treated successfully with thalidomide. Side effects have not been encountered during a 6-month symptom-free period, while he has taken 25 mg per day. The drug is currently unavailable in this country except for the treatment of leprosy. It is hoped that publication of the dramatic response to thalidomide in this one instance will encourage greater interest in this potentially useful drug.

Behcet Syndrome↗
PubMed1987

Aneurysmal bone cyst of the mandible.

The case of a 48-year-old male patient with a slowly growing mass in the right molar region of the mandible is presented. The biopsy specimen showed an aneurysmal bone cyst. After radiation therapy failed to arrest the process, the patient was treated surgically via an external approach. Between the time of the initial presentation and the date of definitive surgery 9 months later, a dramatic change was noted in the roentgenographic pattern of the lesion, demonstrating early and late stages in the development of an aneurysmal bone cyst. There has been no recurrence in a 17-year follow-up period.

Bone Cysts↗
PubMed1984

Oral presentations in non-Hodgkin's lymphoma: a review of thirty-one cases. Part II. Fourteen cases arising in bone.

In a series of 31 patients with NHL presenting in the oral region, nine lesions were in the maxilla and 5 were in the mandible, for a total of 14 (45%) lesions that arose in bone. The most common locations were the posterior regions of the maxilla (7 cases) and mandible (4 cases). Diffuse subtypes clearly predominated, 13 out of 14 cases demonstrating this pattern. Six of the cases were in children, and 4 of these qualified as Burkitt's lymphoma. In general, it was found that the statistics relating to survival of patients with jawbone lymphoma correspond closely to the findings reported for skeletal lymphomas. Despite the high incidence of diffuse patterns, 6 of these 14 patients with NHL in bone were alive with no evidence of disease 3 years or longer.

Adult↗
PubMed1983

Oral presentations in non-Hodgkin's lymphoma: a review of thirty-one cases. Part I. Data analysis.

Thirty-one patients with oral manifestations of non-Hodgkin's lymphoma have been studied with reference to age, sex, race, location of lesion in oral cavity, stage of disease on presentation, duration of disease at time of presentation, histologic type, modes of treatment, and survival. There were 6 children and 25 adults, ranging in age from 3 to 89 years. Only 2 of the 31 patients were black. Sex incidence was almost equal, with 17 females and 14 males. In 12 cases the oral findings alone represented the initial presentation of lymphoma. The maxilla, mandible, and palate accounted for 24 of the 31 cases. The preponderance of diffuse histologic patterns was striking (77.4 percent). Eighteen cases (58.0 percent) presented in Stage I or Stage II, indicating relatively limited extent of disease. More generalized involvement was found in the remaining thirteen cases (41.9 percent). Thus, although NHL may appear in the oral region as the first detected evidence of disease, in many patients a work-up will show that the process is widespread in distribution. In this brief series survival data coincide with the established principles that a poorer prognosis is associated with the diffuse histologic pattern, as well as certain identified histiocytic and poorly differentiated lymphocytic subtypes.

Adolescent↗
PubMed1981

Chemotherapy for head and neck cancer relapsing after radiotherapy.

Thirty-nine patients (28 men and 11 women, ages 43 to 83 years) with advanced head and neck epidermoid carcinoma (33 had relapsed from previous radiotherapy) were treated with a three-day bleomycin administration (30 by continuous intravenous infusion and nine by subcutaneous route) followed on the fifth day by intravenous administration of cyclophosphamide + methotrexate + 5-fluorouracil (Bleo-CMF). This drug schedule was based on the cell cycle synchrony principle. Twenty-one of 39 patients (54%) responded (seven complete, 14 partial remission) lasting from 4 to 20 months. The median duration of survival for complete remission, partial remission, and disease progression was 15, ten, and four months, respectively. The Bleo-CMF was well tolerated with minimal toxicity. The effectiveness of this regimen in previously irradiated patients compels us to pursue its application in a randomized study as an adjuvant for Stages III and IV head and neck cancer following maximum eradication of the local disease by surgery and/or radiotherapy.

Adult↗
PubMed1981

Garré's proliferative periostitis occurring simultaneously in four quadrants of the jaws.

Typically, Garré's osteomyelitis affecting the jaws is unilateral and is restricted to the mandible. We are reporting a case in which all four quadrants were involved, an occurrence which we believe must be extremely unusual and has not been reported previously. Conservative management over a period of 3 years resulted in complete resolution, with return of normal facial and osseous contours.

Child↗
PubMed1981

Surgical and pathological considerations in cherubism.

Although cherubism was recognized over half a century ago, there are few reports in the literature describing the overall management of this puzzling and challenging condition. The early onset of this disease and its continued growth result in therapeutic dilemmas with respect to pathological potential, deformity, dysfunction, and possible facial and emotional scarring. This report describes a staged approach to a major case, utilizing the advantages of current advances such as surgical technology, transoral approach, pantomography, and radioscintography. Foremost consideration is given to the histopathology of this and related fibro-osseous diseases. It is concluded that a curettement-recontouring procedure is the surgical modality of choice.

Adolescent↗