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Biomedical subjects

L E Wood

Publications and source records attributed to L E Wood.

6 recordsLinked to original sources
PubMed1985

Specific chemical modifications in the beta-cleft site of hemoglobin. Potential anti-sickling agents with hybrid functionalities.

Ester and aldehyde groups have been combined to produce molecules with hybrid functionalities that might be effective in modifying hemoglobin. In this series of compounds, the reagents that carry the combination of an anionic charge and an aldehyde as binding groups show a strong preference for the beta-cleft region of the protein and produce selective modification therein. 5-Formylaspirin and related oxalyl, malonyl, and fumaryl monoaldehyde monoester derivatives form a new class of substances for which modification of hemoglobin is very substantial and is inhibited by inositol hexaphosphate.

Acylation↗
PubMed1978

Efffect of exo- and endo-2-aminobenzonorbornene on the acceleration of efflux of norepinephrine from isolated perfused rabbit atria.

The effect of exo- and endo-2-aminobenzonorbornene on the efflux of norepinephrine (NE) from isolated perfused rabbit atria was studied. These compounds can be considered conformationally rigid analogs of amphetamine and as such can be used to study the stereochemical requirements for amphetamine like activity. The exo isomer was found to produce an acceleration of efflux of previously accumulated 3H-NE from pargyline treated atria from rabbits which had been pretreated with either reserpine or dl-alpha-methyltryrosine (alpha-MT). The endo isomer however was found to accelerate efflux of 3H-NE from pargyline treated atria from reserpine pretreated rabbits but not from rabbits that had been pretreated with alpha-MT.

Animals↗