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Biomedical subjects

L E Smith

Publications and source records attributed to L E Smith.

149 records · Page 9Linked to original sources
PubMedDate not supplied

Idiopathic endolymphatic hydrops and the vestibular aqueduct.

The vestibular aqueduct (VA) and endolymphatic sac were examined topographically in 29 human ears with idiopathic endolymphatic hydrops. When compared with 34 control ears, there was found to be a slight but statistically significant reduction in the width (P less than 0.005) and length (P less than 0.05) of the vestibular aqueduct. A small hypoplastic endolymphatic sac was found in three of the ears with hydrops but was also present in one control ear. It would appear that a marked reduction in sac size is not a consistent feature in ears with endolymphatic hydrops.

Endolymphatic Sac↗
PubMedDate not supplied

Accuracy of auditory brainstem evoked response with hearing level unknown.

We reported a comparison of auditory brainstem response (ABR)-estimated hearing levels with hearing levels by pure-tone audiogram for 84 ears of 42 children. Their average age was 34 months at the time of ABR and 73 months for the audiogram. Thus, all of these children were managed clinically on the basis of their ABR results. The ABR accurately predicted the pure-tone average (PTA) in 76% and was in error by no more than about +/- 10-12 dB in another 18%.

Audiometry↗
PubMedDate not supplied

Conjunctival biopsy in patients with Kawasaki disease.

Kawasaki disease (KD) is an acute vasculitis of infants and young children that is associated with bilateral nonexudative conjunctivitis during the acute illness. Epidemiologic evidence has suggested an infectious cause but the etiology of KD remains unknown. We examined conjunctival biopsy specimens from seven patients with typical KD to characterize the pathologic changes during the acute disease. Light microscopic examination revealed nonspecific, mild inflammatory changes that included vascular dilatation, infiltration with scattered lymphocytes, increased numbers of plasma cells in the conjunctival stroma, and increased prominence of goblet cells in the epithelium. No pathogens were identified by special stains for bacteria and rickettsiae, nor were viral particles seen by electron microscopy. We conclude that the conjunctivitis of acute KD is characterized by vascular dilatation with a mild mononuclear cell response with no pathognomonic features. The conjunctiva can be readily sampled in these patients and biopsy may prove useful in selected patients to exclude other clinical entities in the differential diagnosis.

Acute Disease↗