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Biomedical subjects

L E Klein

Publications and source records attributed to L E Klein.

43 records · Page 3Linked to original sources
PubMed1981

Effect of triiodothyronine on (Na+ G K+)-adenosine triphosphatase and (Na+ + Mg2+)-dependent phosphorylated intermediate in rat salivary glands.

The present studies concern the effect of triiodothyronine (T3) on rat salivary (Na+ + K+)-adenosine triphosphatase (NaK-ATPase). The results indicate that T3 selectively increased submandibular and parotid NaK-ATPase units with a single, large dose of T3, different dosage of T3, three successive doses of T3 given on alternate days, and "physiological" doses of T3 with daily injection for 2 weeks. Sublingual NaK-ATPase was insensitive to T3 in the above experiments. The effect of T3 on submandibular and parotid NaK-ATPase is selective since Mg-ATPase and 5'-nucleotidase showed no significant differences under different thyroid status. The lack of response of NaK-ATPase to reverse T3, further substantiates the specificity of T3 on salivary NaK-ATPase.

Animals↗
PubMed1981

Effect of physician tutorials on prescribing patterns of graduate physicians.

Pessimism has been expressed in the medical literature as to the efficacy of educational interventions in modifying practice patterns of graduate physicians. As a result, a prospective controlled trial of a specific form of educational intervention, the physician tutorial, was designed to test this belief. Physicians in the experimental group were surveyed to assess their knowledge of the effectiveness, cost and side effects of antibiotics used in the treatment of a preselected index condition, and a tutorial was developed to modify suboptimal prescribing patterns. Antibiotic usage patterns were initially similar for the experimental and control physicians. Prescribing patterns afterwards were statistically different, with the experimental physicians increasing their prescription of the encouraged antibiotics and decreasing that of the discouraged antibiotics. This was accompanied by a statistically significant decrease in direct drug charges. These results suggest that educational programs can be effective in modifying graduate physician prescribing practices.

Anti-Bacterial Agents↗
PubMed1981

Adverse drug reactions among the elderly: a reassessment.

The elderly are widely believed to be predisposed to adverse drug reactions, chiefly because of the large quantities of drugs they consume, combined with the effects of aging on distribution, metabolism, and the patterns of drug usage. These beliefs affect the physician's prescribing behavior. To study the validity of these concepts, the supporting medical literature was reviewed. Existing studies of the rates of adverse drug reactions have several methodologic limitations, including inadequate control for disease severity, the use of calculation denominators which overestimate incidence, and dependence upon definitions of medication error rates which do not adequately reflect the potential for adverse outcome. Further studies are needed for clarification of drug-use patterns and problems among the elderly.

Aged↗
PubMedDate not supplied

Detection and management of mental health problems of older patients by primary care providers.

Evidence is accruing that older individuals receive little attention for mental health problems and that any attention that is given is most often within the primary care setting. A randomized clinical trial was carried out at a primary care clinic of The Johns Hopkins University, Baltimore, testing the ability of feedback of the results of a screening instrument (the General Health Questionnaire) to increase awareness in clinicians of the emotional and psychological problems of their patients. This report contrasts those aged 65 years and older with younger patients. Detection and management of mental morbidity were lower for older individuals, but the feedback intervention increased the likelihood of attention to these problems. This was not true for younger patients. Detection was significantly higher for older patients when screening data were made available, as was management, although the latter difference was not statistically significant. There was evidence as well that the intervention moved clinicians to greater congruence with their older patients in the perception that current mental health problems existed. These findings have important implications for primary care.

Adult↗