Time for action.
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Black or African American↗
Biomedical subjects
L E Harris
Publications and source records attributed to L E Harris.
Effect of hypertension and type II diabetes on renal function in an urban population.
End-stage renal disease is a devastating complication of essential hypertension and type II diabetes mellitus, conditions that commonly occur together. We and others have previously suggested that the outcome of both conditions may be influenced by more aggressive treatment. We examined a large general medicine outpatient population; 72% were black and 41% were diabetic (95% type II). Decreased renal function, defined as a serum creatinine greater than or equal to mg/dL, developed in 18.1%. A multivariable logistic regression analysis identified glucose control, systolic blood pressure level, and male gender as indicators of decreased renal function. These data suggested that both glucose and blood pressure control may decrease the frequency of impaired renal function. However, when these variables were controlled, blacks still had almost twice the risk for renal dysfunction of whites. The data draw attention to, and elucidate the exceptionally high incidence of renal dysfunction in hypertensive blacks with or without diabetes. Further, they may explain the inordinate numbers of blacks with hypertension requiring dialysis. Prospective trials to test the efficacy of blood pressure and glucose control on the course of renal disease in hypertensive and/or type II diabetic patients are warranted.
Adult↗
Comparison of serum cholesterol in children fed high, moderate, or low cholesterol milk diets during neonatal period.
The long-term effects of milk diets in infancy on the blood serum cholesterol concentrations were studied in 97 school children 7-12 yr of age. Detailed histories were available for these children with respect to their diets during infancy. The major criterion for inclusion in the study was milk (human milk, cow's milk, or commercial formula) as the exclusive source of diet cholesterol during the first 3 mo of life. Fasting blood cholesterol and triglycerides were measured in these 97 school children, and the current diets of 29 of the 97 were evaluated for daily cholesterol intake. A 7-day diet diary was recorded, the food intake was measured and analyzed for nutrients, and validity of the diets was verified by determination of urinary nitrogen excretion. Results of the study showed that the school children fed a low cholesterol formula during infancy had a mean serum cholesterol value 7-12 yr later that was lower than the mean values of the groups fed greater amounts of cholesterol in infancy. Analysis of current diets of 29 of the 97 school children showed that their current dietary intake of cholesterol was low. Dietary intake of cholesterol did not have a noticeable effect on the serum cholesterol levels of the 29 children.
Animals↗
Congenital and acquired abnormalities observed in live-born and stillborn neonates.
This report records the congenital and acquired abnormalities observed during the first 4 days of life in 21,142 live-born infants. Gross abnormalities observed in 300 stillborns also are recorded. The abnormalities are those thought to be of clinical or possibly clinical significance. Also included are other conditions ordinarily not considered to be a congenital abnormality, such as convulsions. Definitions are given when indicated. The incidence rates per 1,000 births for specific malformation noted in the first 4 days of life are provided for all births, for live births, for live births under 2,500 g, and for stillbirths. The need for accurate studies of specific forms of congenital malformations is reiterated. The rate for all malformations combined is not given since it is difficult to interpret or use for comparisons because of variations in the definition of malformation and in completeness of ascertainment in different studies.
Birth Weight↗
Cytomegalic inclusion disease treated with idoxuridine and novobiocin.
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Cytomegalovirus Infections↗