Search PubMed⌕ Search

Biomedical subjects

L Dunn

Publications and source records attributed to L Dunn.

At least 55 records · Page 3Linked to original sources
PubMed1989

Respiratory muscle performance in normal elderly subjects and patients with COPD.

We studied the reproducibility of tests of RM performance in normal elderly subjects and compared their performance with that of patients with COPD. The RM strength was measured as MIP and MEP. The RM endurance was measured using a two-minute incremental threshold loading test. The max load, the average Ppk as %MIP at max load and the Pmean at max load were taken as measures of respiratory muscle endurance. The MIP, but not MEP, was less in COPD patients than in normal subjects (p less than 0.05). There was a small increase in between visits, in MIP in the normal subjects. All measures of RM endurance were much lower in the COPD group than in the normal elderly (p less than 0.05). We conclude that (1) RM strength and endurance are reproducible in normal elderly subjects and patients with COPD, (2) that COPD subjects have decreased RM strength and endurance compared with normal elderly subjects, and (3) that in COPD subjects RM endurance is compromised more than RM strength.

Aged↗
PubMed1988

Squamous cell carcinoma of skin developing in a skin graft donor site.

We report a case of squamous cell carcinoma of the skin of the right ring finger which was treated by excision and split skin grafting. Three months later the patient presented with a further lesion at the margin of the skin graft donor site on the right thigh. Excision biopsy of this second lesion revealed a squamous cell carcinoma of a similar pathological appearance to the original lesion. We have been unable to trace any previous similar reports. A possible pathological basis for the sequence of events is discussed.

Carcinoma, Squamous Cell↗
PubMed1988

Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function: preliminary report of a randomized trial.

In a prospective randomized trial, we studied the effects of early hypocaloric enteral feedings (PO) begun at 48 hours of age in 19 infants compared with 20 infants who received no enteral feedings (NPO) for at least the first 9 days of life. Both groups initially received the majority of their calories by parenteral alimentation. The groups were similar with respect to birth weight, gestational age, sex, Apgar score, and major neonatal diagnoses. The early enteral feeds proved to be significantly beneficial without an increased incidence of complications. The PO group reached full enteral feedings faster than the NPO group (31.2 vs 47.3 days). The PO group had a greater decline in serum bilirubin concentration over the first 2 weeks of life and spent less time under phototherapy (6.8 vs 9.5 days). Less cholestasis was observed among the PO infants (6.7% vs 33%), and peak direct bilirubin levels were also lower (0.7 vs 2.5 mg/dL). Osteopenia of prematurity, manifested by significantly lower alkaline phosphatase activity, was also decreased in the PO group, perhaps because of greater calcium intake during the first month among PO infants (1.3 vs 0.8 g). Compared with complete bowel rest, early onset of hypocaloric enteral feedings has beneficial effects on indirect hyperbilirubinemia, cholestatic jaundice, and metabolic bone disease of very low birth weight infants.

Alkaline Phosphatase↗
PubMed1988

Phrenic nerve function and its relationship to atelectasis after coronary artery bypass surgery.

Atelectasis following coronary artery bypass surgery (CAB) occurs in the majority of patients. To determine the importance of operative variables in the development of postoperative atelectasis and the incidence of phrenic nerve injury caused by topical cold cardioplegic solution, we studied 57 patients (53 male, four female) undergoing CAB. Their mean age, +/- SD, was 58 +/- 13 years. Transcutaneous stimulation was used to evaluate phrenic nerve function preoperatively and postoperatively in 52 patients. An unequivocal paresis of the phrenic nerve was documented in five patients. In an additional 27 patients, the amplitude of the compound diaphragm action potential was reduced postoperatively. However, methodologic limitations did not allow the conclusion that this was secondary to a phrenic axonal degeneration. Discriminant analysis of intraoperative variables showed more severe atelectasis with a larger number of grafts, with a longer operative and bypass time, when the pleural space was entered, when a right atrial drain and a cardiac insulating pad were not used, and with a lower body temperature. It is concluded that phrenic paresis may occur after CAB and topical cold cardioplegia, but that other factors must explain the atelectasis found in the majority of patients.

Cardioplegic Solutions↗
PubMed1988

The clinical consequences of payment limitations: the experience of a private psychiatric hospital.

In the search for cost efficiency, psychiatric patients are experiencing greater restrictions on their insurance benefits. Managed psychiatric care may provide a useful alternative to arbitrary benefit limits, but may also interfere with treatment, especially if there is a disagreement between the manager and the responsible clinician. Three clinical vignettes are presented and the implications of possible premature discharge described as a first step in building a research agenda on the clinical consequences of managed psychiatric care.

Baltimore↗
PubMed1988

They are not alone: lending support to family care givers.

Families caring for a frail elderly loved one at home face numerous problems and crises and often become incapacitated, sometimes breaking down completely, in their efforts to cope. Research indicates that education, information and referral services, and support and respite services can significantly improve coping abilities and relieve care givers' burden. During the past eight years, the Neurological Sciences Center's Education & Family Support Services (E&FSS) of Good Samaritan Hospital and Medical Center, Portland, OR, has become a leader in developing these services for families. E&FSS programs include Helping You Care; Caregiver Series; Caregiver Support Group; POPS; Polishing Our People Skills; Neurological Coalition; Caregiver's Respite Program; Legal/Financial Planning class; and the E&FSS Resource Center. The program also provides public education in the form of three major programs each year, videotapes, and fact sheets. The program benefits the facility by providing direct revenues, referring clients to medical services and physicians, and enhancing the facility's image in the community.

Aged↗
PubMed1987

The partial dependency of human prostatic growth factor on steroid hormones in stimulating thymidine incorporation into DNA.

Growth factors stimulating DNA synthesis in mouse 3T3, human DU145, and LNCaP were partially purified from human benign hyperplastic and cancerous prostates. These factors have a high affinity for heparin sepharose and are eluted from the heparin-sepharose column, at 1.2 to 1.9 M NaCl. In normal prostates, the high affinity human prostatic growth factor occurred only in extremely small amounts. The high affinity growth factors stimulate DNA synthesis in 3T3, DU145, and LNCaP. Stimulation was significantly enhanced by 5 alpha-dihydrotestosterone and 17 beta-estradiol in the androgen sensitive LNCaP cell line. SDS-PAGE and isoelectrofocusing confirmed that the partially purified factors had a molecular weight of 18 kDa and acidic isoelectric points of pH 3.6 and 4.7.

Adult↗
PubMed1984

Adverse toxic reaction to aqueous procaine penicillin G.

Aqueous procaine penicillin G therapy is frequently used in ambulatory care settings and clinicians have long been alerted to the potential allergic reactions that may occur with this therapy; however, the nonallergic toxic reaction has not been as widely publicized. A possible psychotic-like, pseudoanaphylactic reaction may occur within 60 seconds following an injection of aqueous procaine penicillin G. Two case reports and a review of the literature will be presented to alert clinicians to this reaction. Suggestions for management will also be offered.

Adolescent↗
PubMed1982

Reactions of psychiatric patients to the Three Mile Island nuclear accident.

The reaction of patients in the community mental health system to the nuclear accident at Three Mile Island (TMI), Middletown, Pa, were assessed. The sample was composed of 151 patients from the TMI area and 64 patients from a comparison site where a similar nuclear plant is located. Mental health status was determined for the period immediately after the accident, nine to ten months later, and one year later. No significant differences were found between the TMI group and the comparison group. To isolate risk factors within the TMI group, patients who were most distressed were compared with patients with the least distress. The results showed that quality of network support and viewing TMI as dangerous were significantly associated with mental health.

Accidents↗
PubMedDate not supplied

Self-efficacy for coping with cancer: revision of the Cancer Behavior Inventory (version 2.0).

The Cancer Behavior Inventory (CBI), a measure of self-efficacy for coping with cancer, was revised by adding a new stress management scale and reducing its length from 43 to 33 items. The 33-item CBI was administered to 280 cancer patients. A principal factors analysis with varimax rotation yielded the hypothesized seven factors (alphas in parentheses): (1) maintenance of activity and independence (alpha=0.86), (2) seeking and understanding medical information (alpha=0.88), (3) stress management (alpha=0.86), (4) coping with treatment-related side-effects (alpha=0.82), (5) accepting cancer/maintaining positive attitude (alpha=0.86), (6) affective regulation (alpha=0.81), and (7) seeking support (alpha=0.80). The alpha for the entire CBI was 0.94, the test-retest (1 week) reliability coefficient was 0.74, and correlations with measures of quality of life and coping supported its validity. The CBI may be useful to researchers and clinicians and can be integrated into a self-regulation model of coping.

Adaptation, Psychological↗
PubMedDate not supplied

Consumptive coagulopathy in utero associated with multiple vascular malformations.

We report a postmature male infant who died at age 2 h of asphyxiating pulmonary hemorrhage. Autopsy found edema, serous ascites, and vascular malformations within myocardium, lung, mediastinal soft tissue, thoracic-wall skeletal muscle, spleen, thyroid and adrenal glands, and pancreas. The pulmonary malformations had arteriovenous features, while those elsewhere were predominantly capillary; many of the latter contained fibrinous thrombi. Circulating nucleated erythrocytes, siderosis of proximal renal tubular epithelium, and intrahepatocytic and intracanalicular cholestasis were present. We believe that these findings represent an unusual instance of hemangioma-associated consumptive coagulopathy and intravascular hemolysis (Kasabach-Merritt syndrome) of antenatal onset, associated with features suggestive of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome).

Blood Vessels↗
PubMedDate not supplied

Breath of life.

Explore the source record for details and available documents.

Career Mobility↗
PubMedDate not supplied

Oxygen therapy.

This article aims to give a general overview of oxygen therapy, both in the short and long term. Various methods of oxygen delivery and storage are discussed, along with the nurse's role in caring for a patient receiving oxygen therapy.

Blood Gas Analysis↗