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Biomedical subjects

L Dubin

Publications and source records attributed to L Dubin.

At least 55 records · Page 3Linked to original sources
PubMed1977

Varicocelectomy: 986 cases in a twelve-year study.

Over a twelve-year period, surgical correction of varicocele was performed on 986 selected subfertile men. They were followed up for at least two years after surgery. Semen quality was improved in 70 per cent, and 53 per cent of the wives became pregnant. Statistically, the results were better in terms of semen quality improvement and pregnancy for patients who had preoperative sperm counts over 10 million per milliliter (85 per cent improved, 70 per cent pregnancy rate) than for patients who had preoperative sperm counts of less than 10 million per milliliter (35 per cent improved, 27 per cent pregnancy rate). The empirical use of postoperative human chorionic gonadotropin therapy in this latter group improved results significantly (55 per cent improved, 45 per cent pregnancy rate).

Female↗
PubMed1976

Clinical experience with sperm antibody testing.

Of the 724 patients examined for circulating spermagglutinating antibodies by the Kibrick spermagglutination test, 95 (13.1%) were found to be positive. Almost 20% of the 406 male patients demonstrated autoantibodies. This high incidence may be explained by the selected population studied. Of 50 males tested who demonstrated more than 10% agglutination in their semen, but otherwise were normospermic, 42% demonstrated autoantibodies. Of the 318 females examined, 14 (4.4%) demonstrated sperm-agglutinating antibodies. Of the 315 male and female patients examined for circulating sperm-immobilizing antibodies by the Isojima sperm-immobilization test, 14 (4.5%) were found to have antibodies. Of the 162 males treated, 10 (6%) were positive for antibodies by this technique, as were 4 (3%) of the 153 women tested.

Autoantibodies↗
PubMed1975

A coital technique for promotion of fertility.

In selected cases of subfertile men, the first portion of the split ejaculate is superior to the specimen considered as a whole with regard to sperm density, motility, and cytology, and also in those cases in which there is increased seminal viscosity in the whole ejaculate. Use of the coital technique in which the husband withdraws his penis from the vagina after deposition of the better first portion of the ejaculate during the fertile time of the wife's cycle has resulted in rapidly achieving pregnancy in many instances in which the marriages had been barren for years. A total of 33 cases of pregnancy ascribed to this coital technique in the past four years, with detailed analyses of whole and split ejaculates, is presented.

Cell Count↗
PubMed1975

Stimulation of ejaculated human spermatozoa by caffeine.

Caffeine (1, 3, 7-trimethyl-2, 6-dioxypurine), a cyclic nucleotide phosphodiesterase inhibitor, increased the motility of ejaculated human spermatozoa. Both the percent motility and the grade of forward progression were significantly increased (P smaller than 0.001) and maintained in the presence of 6 mM of caffeine for up to five hours at 37 C. Increases in percent motility greater than two-fold occurred among the groups having low initial motility. Increases in samples with a high initial percent motility (greater than 60%) were not as dramatic, but they were still significant. In addition, the grade of motility or forward progression was increased in all groups up to one full unit. The longevity of the spermatozoa, judged by activity, was also increased for up to five hours.

Caffeine↗
PubMed1975

Varicocelectomy as therapy in male infertility: a study of 504 cases.

Over a ten-year period, surgical correction of varicocele was performed on 504 selected subfertile men. They were followed up for at least one year after surgery. Semen quality was improved in 71% and 55% of the wives became pregnant. Statistically, the results were better in terms of semen quality improvement and pregnancy for patients who had preoperative sperm counts over 10 million/ml (88% improved, 68% pregnancy rate) than for patients who had preoperative sperm counts of less than 10 million/ml (33% improved, 23% pregnancy rate). The empirical use of postoperative human chorionic gonadotropin therapy in this latter group improved results significantly (56% improved, 44% pregnancy rate).

Cell Count↗
PubMed1975

Circulating sperm-agglutinating antibodies in azoospermic men with congenital bilateral absence of the vasa deferentia.

Congenital bilateral absence of the vasa deferentia has been found to be the cause for azoospermia in 101 patients who have been examined in our urologic practice since 1956. This represents approximately 2% of the 5112 patients seen during that time because of problems relating to infertility. Of these 101 men, 29 have had their sera tested for the presence of circulating sperm-agglutinating antibodies. The Shulman15 modification of the macroscopic gelatin sperm-agglutination test of Kibrick et al6 was used. None of these patients had had testicular biopsy. Significantly high titers (1:32 or greater) of antibodies were found in 18 (62.1%) men, low titers (1:16 or less) in five (17.2%), and no antibodies in six (20.7%).

Agglutinins↗
PubMed1975

Infertility practice and Orthodox Jewish law.

The evaluation and management of infertility problems in Orthodox Jewish couples can be made difficult because of restrictions which may be imposed by religious rules. The origins of the religious laws governing problems such as semen collection, diagnostic and therapeutic genital surgery, menstruation, and homologous and donor insemination are reviewed. Contemporary Rabbinic authorities are quoted; their opinions may serve as guidelines for the patient and physician dealing with infertility problems.

Biopsy↗
PubMed1975

Varicocelectomy as therapy in male infertility: a study of 504 cases.

During a 10-year period 504 selected subfertile men underwent surgical correction of varicocele and had a followup of at least 1 year. Improved semen quality was reported in 71 per cent of the men and 55 per cent of the wives became pregnant. Statistically, results were better in terms of semen quality improvement and pregnancy in patients who had preoperative sperm counts greater than 10 million per cc (88 per cent improved, 68 per cent pregnant) compared to patients who had preoperative sperm counts of less than 10 million per cc (33 per cent improved, 23 per cent pregnant). The impiric use of postoperative human chorionic gonadotropin therapy in the latter group of patients improves results significantly (56 per cent improved, 44 per cent pregnant).

Adult↗
PubMed1975

A new method of promoting fertility.

It has been demonstrated that in selected cases of subfertility in men, the first portion of the split ejaculate is superior to the specimen considered as a whole with regard to sperm density, sperm motility, and sperm morphology and also in those cases where there is increased seminal viscosity in the whole ejaculate. The use of a new coital technic, in which the husband practices coital withdrawal after the deposition of the better first portion of the ejaculate during the fertile time of the wife's cycle, has resulted in rapidly achieving pregnancy in many instances where the marriages had been barren for years. A documentation of 33 instances of pregnancy ascribed to this coital technic in the past 4 years, with detailed analyses of whole and split ejaculate semen, is presented.

Cell Count↗