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L Drexler

Publications and source records attributed to L Drexler.

8 recordsLinked to original sources
PubMed1980

Aspergillus terreus infective endocarditis on a porcine heterograft valve.

We present the first reported case of Aspergillus endocarditis occurring on a porcine heterograft prosthesis and discuss the literature regarding both Aspergillus endocarditis and endocarditis on a porcine valve. A 65-year-old man underwent aortic valve replacement with a porcine heterograft. Several weeks later he exhibited signs of infection and then of valve failure. Upon removal, the porcine valve substance was found to be grossly infiltrated and destroyed by the Aspergillus organism. The porcine valve has an excellent reputation of being resistant to infection and relatively easy to sterilize by medical management alone. Several surveys attest to the low incidence of endocarditis. Because of our experience with the destruction caused by Aspergillus, however, and because antimicrobials generally fail to eradicate this organism, we urge prompt operation to remove the heterograft valve involved with infection by this organism. The valve diseased with Aspergillus should be replaced with a mechanical prosthesis. In the aortic position, extra-anatomic replacement should be considered to facilitate eradication of periannular infection postoperatively.

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Evaluation of modified Stuart's medium in Culturettes for transport of Neisseria gonorrhoeae.

A prospective study compared rates of isolation of Neisseria Gonorrhoeae after immediate plating of clinical specimens onto Thayer-Martin medium with isolation rates after initial transport in modified Stuart's medium (MST) contained in Culturettes. Of 75 specimens positive for Neisseria gonorrhoeae after immediate plating onto Thayer-Martin medium, 65 (87%) were also positive after being held in MST medium for < or = 8 hr. Twenty (95%) of 21 clinical specimens remained positive after being held in MST medium for < or = 3 hr. However, the rates of isolation of N. gonorrhoeae were significantly reduced after transport for 24 and 48 hr; 60% and 27% of specimens, respectively, yielded N. gonorrhoeae-positive cultures after these intervals. Therefore, it is concluded the MST medium in Culturettes is an acceptable transport medium for specimens containing N. gonorrhoeae when transport time prior to inoculation of growth medium is < or = 3 hr.

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