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Biomedical subjects

L Diana

Publications and source records attributed to L Diana.

34 records · Page 2Linked to original sources

Influence of uremic middle molecules on in vitro stimulated lymphocytes and interleukin-2 production.

The influence of uremic middle molecules on in vitro lymphocyte blast transformation and interleukin-2 production was studied in 12 patients on long-term hemodialysis and 12 healthy control subjects with normal kidney function. Middle molecules inhibit phytohemoagglutinin induced lymphocyte proliferation in a concentration dependent fashion, achieving more than 50% inhibition of tritiated thymidine incorporation after 72 hrs in culture. In addition, there was less interleukin-2 production in the long-term hemodialysis patients studied compared with healthy control subjects.

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