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Biomedical subjects

L Demling

Publications and source records attributed to L Demling.

At least 217 records · Page 12Linked to original sources
PubMed1975

Endoscopic papillotomy. Experimental studies and initial clinical experience.

Experimental studies carried out in 11 dogs have shown that, with the aid of a high frequency diathermy probe, satisfactory papillotomies can be performed. On the basis of these results, endoscopic papillotomies have been carried out in 23 patients. Indications for papillotomy were biliary calculi in 11 high-risk patients, in 6 cases calculi overlooked during bile duct surgery, and in 3 patients recurrent calculi after previous cholecystectomy. In 3 patients circumscribed papillary stenosis indicated endoscopic papillotomy. Papillotomy was successful in all 23 cases. In 9 cases the calculi had been passed spontaneously after 3-5 days. In 10 patients the stones had to be extracted using the Dormia basket or a wire loop, and in one patient the stone had to be removed surgically. In one of these patients endoscopic papillotomy was followed by an attack of pancreatitis which subsided after 3 days. Further complications, in particular the occurrence of massive bleeding after papillotomy, were not observed.

Ampulla of Vater↗
PubMed1975

Is chronic gastritis a reversible process? Follow-up study of gastritis by step-wise biopsy.

In 36 patients step-wise biopsies of gastric mucosa were performed in 1971 and in 1974/75. A comparison of the histological changes revealed identical findings in 15, progression of superficial gastritis in 9 and regression of superficial gastritis in 7. In 5 patients regression of chronic atrophic gastritis was seen. In one patient an essentially normal mucosa was found in all biopsy specimens, in other patients parietal cells reappeared without any specific therapy.

Adult↗
PubMed1975

Protein synthesis in human gastric mucosa: effects of pentagastrin, secretin, and 13-nle-motilin.

This study in man (n = 35) deals with the effects of in vivo administration of pentagastrin, synthetic secretin, and 13-norleucine-motilin (13-nle-motillin), respectively, on the in vitro incorporation of 14C-leucine into gastric mucosal protein. From the results presented it may be concluded that pentagastrin has a trophic influence on gastric mucosa in man, too, while protein synthesis in human duodenal mucosa remains unaltered. As the incorporatin of 14C-leucine into gastric mucosal protein is inhibited both by secretion and 13-nle-motiln, it may be hypothesised that secretin and motilin act as functional antagonists of gastrin in the regulation of human gastric mucosal protein synthesis.

Adult↗
PubMed1975

13-norleucine motilin versus pentagastrin: contrasting and competitive effects on gastrointestinal myoelectrical activity in the conscious dog.

In conscious fasted dogs, with chronically-implanted electrodes in stomach and small intestine, typical aborally-propagated interdigestive myoelectric complexes were induced by the infusion of 13-nor-leucine motilin (13-Nle-M); whereas when the normal interdigestive activity was abolished by the infusion of pentagastrin, the resulting 'postprandial' pattern of activity was not significantly modified by the administration of 13-Nle-M. Results from this study provide further evidence that Motilin as well as Gastrin may be involved in the control of gastrointestinal motility in dogs.

Animals↗
PubMed1975

On the pathophysiology of peptic ulcer formation.

Peptic ulcer in man characterized by its rarity, singularity and chronicity coupled with a tendency to recidivate. Its rarity suggest the presence of protective mechanisms. The mucus barrier, cell regeneration and blood flow might be mentioned here. The singularity and chronic nature of this disease, together with the observation of varying lesion healing following polypectomy and gastric freezing, point to the probability of a vascular factor. The connecting link between an impaired protective mechanism and a vascular factor is the back diffusion of acid. A "weakened" mucus barrier opens up the way for an attack by the hydrogen ions on vessels in the regions of the stomach which manifest only a poorly developed vascular plexus. To such regions belongs, in particular, the lesser curvature. For the therapy, the following consequences derive from these pathophysiological condiserations: 1. Attenuation of the aggressive gastric juice by anticholinergics and antihistamines of the H2 receptor blocker type and secretin. 2 Distraction of the aggressor by a diet capable of producing a buffering effect, antacids, antipepsins and alkaline pancreatic secretion stimulated by secretin. 3. Strengthening of the mucus barrier by the administration of carbenoxolone. 4. Reduction of the vascular susceptibility to the formation of thromboses.

Animals↗
PubMed1975

[The mode of action of bisacodyl on the smooth muscle of the small and the large intestine of the guinea pig].

4,4'-Diacetoxy-diphenyl-(pyridyl-2)-methan (Bisacodyl, Dulcolax, 12--240 mug/ml) was shown to initiate dose-dependently contracile responses in the guinea pig isolated terminal ileum and taenia coli (a preparation of pure longitudinal muscle fibers). In contrast to muscle contractions induced by 1 mug/ml acetylcholine (ACh) and 1 mug/ml histamine, respectively bis-acodyl-induced contractile responses were antagonized neither by the anticholinergic agent atropine (6 mug/ml) nor by the antihistaminic compound pheniramine (6 mug/ml). On the other hand, bisacodyl inhibited contractile responses induced by ACh or histamine in a dose-dependent manner. The possibility that bisacodyl-induced contractions were due to a fall in cyclic 3,5-AMP level was excluded by estimation of endogenous cyclo-AMP. Since exogenous cyclic 3,5-AMP (which should possess calcium-antagonistic properties in smooth muscle) as well as verapamil (a calcium inhibitor) inhibited bisacodyl-induced contractions, a site of action on the calcium-dependent contractile system of the smooth muscle cell was discussed. Furthermore, bisacodyl should diminish the sensibility of the contractile system to other contractile compounds (ACh, histamine).

Acetylcholine↗
PubMed1975

Treatment of duodenal ulcer with a long-acting synthetic secretin: a pilot trial.

In three male duodenal ulcer patients, the effects of a 4-week treatment with a long-acting synthetic secretin -- daily s.c. administrations of 10 clinical units secretin/kg b.w. -- were assessed symptomatically, endoscopically, immunologically, and by means of gastric and pancreatic secretory analyses. Improvement in epigastric pain was noted within a few days following the onset of secretin therapy. In all cases, duodenoscopy revealed complete healing of ulcers after a 2- to 3-week treatment period. Before therapy, cutaneous anaphylactoid reactions due to intradermal injections of secretin could be elicited in each subject; skin reactions were found mitigated after 4 weeks of therapeutic secretin administration thus suggesting some desensitisation. Neither gastric acid secretion nor pancreatic bicarbonate production were substantially influenced by the 4-week course of secretin therapy; consequently, prevention of ulcer relapse is rather unlikely to be achievable with the conditions employed in this study. However, it seems therapeutically promising that the duodenal ulcers under study showed complete healing already after 2-3 weeks of secretin administration.

Adult↗