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Biomedical subjects

L Demling

Publications and source records attributed to L Demling.

At least 19 recordsLinked to original sources
PubMed1995

[20 years of endoscopic papillotomy. Analysis of 2752 patients at Erlangen Hospital].

Following the development and introduction of endoscopic papillotomy (EPT), 2752 procedures were performed at Erlangen University Hospitals between 1973 and 1993. All papillotomies were evaluated with regard to indications, technique, results, complications and mortality. To show the development process clearly, results for the periods 1973-1980 (A), 1981-1987 (B) and 1988-1993 (C) were summarised separately. The proportion of patients with common bile duct stones was 91% in group A, 60% in group B and 41% in group C. By contrast the number of papillotomies for malignant disease rose from 1% (A) to 26% (B) and 29% (C). More recent indications such as chronic pancreatitis (11%), biliary pancreatitis (5%) and others (for example sphincter of Oddi dysfunction) (11%) were first seen in group C. While the Erlangen standard papillotomy was used in almost all cases in group A (96%), the precut technique was used (mostly with needle knife) in one-third of all papillotomies in groups B and C (32%). The success rate for EPT in all three periods was highest for common bile duct stones (from 96% for group A to 98% for groups B and C). For malignancies, the success rate was lower (89% in groups B and C). The complication rate fell significantly with time (P < 0.05) from 11% (A) to 7.6% (B) and 6.3% (C). Precut techniques did not increase the complication rate. While 71% of all complications were treated surgically in period A, the proportions fell to 28% (B) and then to 7.5% (C). Method-related mortality fell from 1.1% (A) to 0.4% (B) and 0.5% (C).(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1994

[Crohn disease caused by antibiotics? A medical hypothesis based on epidemiologic data].

The increasing incidence of Crohn's disease over the last 50 years has paralleled the growing use of antibiotics in human and veterinary medicine. Administered at inadequate doses, antibiotics can induce in bacteria a capability for producing toxins. Statistical considerations also indicate that prior antibiotic treatment promotes the development of Crohn's disease. It seems logical to assume that, in persons with a relevant genetic predisposition, this disease is caused by intestinal bacteria, the biological (not morphological) properties of which have been modified by antibiotics.

Anti-Bacterial Agents↗
PubMed1994

Is Crohn's disease caused by antibiotics?

The increase in CD that has taken place over the last 50 years has paralleled the increasing use of antibiotics in human and veterinary medicine. Insufficient doses of antibiotics can induce a capacity for toxin production in bacteria, or can make them invasive. Prior antibiotic therapy also promotes the outbreak of CD to a statistically demonstrable extent. It may clearly be assumed that CD is caused in genetically susceptible persons by intestinal bacteria whose biological (but not morphological) properties have been altered by antibiotics.

Animals↗
PubMed1994

Acid in essential dyspepsia.

ED is caused mainly by motility disorders in the upper gastrointestinal tract. Prokinetics are therefore a proven therapeutic tool. On the other hand, the gastric mucosa is densely innervated by sensory vagal and sympathetic fibers. These are also responsible for the mediation of discomfort and pain. The "underground" diffusion of acid through an internal leak developed in a damaged mucosa might be capable of triggering ED. This could explain the occasional effectiveness of acid blocking in this type of discomfort.

Animals↗
PubMed1993

[Tamed chaos].

Explore the source record for details and available documents.

Humans↗
PubMed1992

[Chaos research, fractals, fuzzy logic. From stereotypes to reality--consequences for medicine].

Both language and conventional mathematics aim to describe reality. Although language is more flexible, it is usually also inaccurate, while mathematics permits accurate presentations and clear prognoses. However, it is burdened by the fact that it is not everywhere applicable. Such chaotic structures as clouds, or lang-term weather forecasting, for example, cannot be expressed in terms of mathematics. Chaos researchers are attempting, in a non-linear world, to understand mathematically dynamic, apparently unordered systems. In this connection, the fractal dimension also appears--which can be employed in the area of diagnosis to define tumor contours. Fuzzy logic comes closer to reality by replacing the inflexible yes/no by a more or less option and by introducing linguistic nuances into machine-controlled processes. Chaos research and fuzzy logic teach us that there is no such thing as certainty of action or prognosis. In the world as it is, whoever claims to possess it is either naive or guilty of self-deception.

Artificial Intelligence↗