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Biomedical subjects

L Dean

Publications and source records attributed to L Dean.

42 records · Page 3Linked to original sources

High-density lipoprotein cholesterol. Significant bias between methods.

Cholesterol content of the high-density lipoproteins has become of interest in evaluating the risk of development of coronary heart disease. There is an inverse relationship between high-density lipoprotein cholesterol and risk. The authors found a significant bias (11.1 mg/dl; 0.289 mmol/l) in a comparison of a rapid cholesterol oxidase method and the Abell--Kendall method for quantitating high-density lipoprotein cholesterol. The two methods did not differ in the usual range of total serum cholesterol. Since methodology may vary, each laboratory's performance should be assessed prior to use of published risk factor data. The authors then studied normal male and female volunteers aged 20 to 35 years. They conclude that high-density lipoprotein cholesterol is of value as a risk factor indicator in this age group. The relationship of total serum cholesterol to high-density lipoprotein cholesterol was studied. The authors conclude that they are independent indicators. Further, there is a range of efficiency of the high-density lipoprotein lipid-clearing function. Finally, the authors attempted unsuccessfully to predict high-density lipoprotein cholesterol from lipoprotein electrophoresis patterns.

Adult↗

Incidence of anencephaly and other major malformations when oestriol excretion is very low.

A study of 533 women with very low urinary oestriol excretion during the third trimester of pregnancy showed an incidence of major fetal malformations among their infants of 7-1% and a perinatal mortality rate of 14-6%. Thirteen of the malformations were cases of anencephaly, and 26 of the 78 perinatal deaths were due to or associated with major fetal malformations. The incidence of these complications was higher when maternal oestriol excretion was lower. Routine screening by urinary oestriol assay, with fetal radiography when values below 20-8 mumol/24 hours (6 mg/24 h) are detected is the most reliable method of detecting anencephaly before birth.

Anencephaly↗

The tole of towing services at motor vehicle crashes.

A survey of tow truck services operating in a defined area of the south-east suburbs of Melbourne was undertaken to determine their potential for delivering emergency medical care at the scene of crashes. Most towing firms have an association with a panel-beating shop, and operate within a limited area of one to three miles radius. The rapid response of tow trucks to crash scenes is due to their well-developed intelligence network of "spotters" and the short distances the trucks travel. Very little first aid is provided by the drivers, although one-fifth had some first aid training at some time. In about one-half of the calls to crashes a damaged vehicle is still at the scene, in about 20% an ambulance is called, and in about 5% a hospital admission occurs. Direct observation of 22 crashes suggests that on average, tow trucks arrive at a crash scene five minutes before the ambulance, and fifteen minutes before the police. There is a good case for making first aid training a preerequisite for issue of a tow truck operator's license.

Accidents, Traffic↗