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Biomedical subjects

L De Florio

Publications and source records attributed to L De Florio.

30 records · Page 2Linked to original sources
PubMedDate not supplied

Some approaches to the pharmacology of multisubstrate enzyme systems.

Analytical and exploratory in vitro, in situ and in vivo, physio-pharmacotoxicology, from enzymology to population epidemiology, now embraces those approaches that correlate complex dynamic multisubstrate kinetics through conventional and more recent non-invasive quantitative methodologies. Basically, substrates may be classed as pertaining to fundamental energy turnovers (first-order cellular metabolic pathways or networks) and to iso- vs allosteric modulator systems (second-order metabolic control network). Pairs of substrates and cofactors set-up the third-order multienzyme-receptor patterns, which in intact, native in vivo structures establish and maintain the compartmentalized, dynamically superimposed overall coordination of local redox and phosphate potentials. Perturbations of the various levels of the metabolic hierarchy induced by drugs, as well their relaxations, can be readily submitted to non-invasive kinetic analysis. Both indirect and direct titrations of substrate levels, their modelling and statistical ad hoc evaluations of their interrelations can lead to the identification of the multiple sites involved in drug effects as structured at the different orders/levels of concomitant functional variations. Fractal geometries contribute towards defining the space- and time-related events.

Animals↗
PubMedDate not supplied

Magnetic Resonance applications in dental implantology: technical notes and preliminary results.

PURPOSE: To evaluate the possible use of Magnetic Resonance Imaging (MRI) in the field of dental implantology, for identifying the mandibular nerve, as proposed by several authors. MATERIALS AND METHODS: MRI was used for the study of the mandible in ten subjects (five healthy volunteers and five subjects awaiting dental implants). Imaging was performed on a 1.0-T MR scanner with a brain coil. T2 TSE, T1 spin-echo and T2 gradient-echo sequences were performed, both parallel and perpendicular to the horizontal portion of the mandible, with a thickness of 3 mm. RESULTS: In all the subjects MRI clearly identified the intraosseous course of the inferior alveolar neurovascular bundle within the mandibular canal. CONCLUSIONS: MRI appears useful for the depiction of the mandibular canal before dental implantation. Further studies are required to compare the accuracy of MRI and CT based on a statistically significant sample.

Dental Implantation, Endosseous↗