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Biomedical subjects

L Davison

Publications and source records attributed to L Davison.

18 recordsLinked to original sources
PubMed2005

Aspects of design, structure, performance and operation of reed beds--eight years' experience in northeastern New South Wales, Australia.

Reed beds (horizontal subsurface flow constructed wetlands) have been employed as secondary treatment devices in on-site and decentralised wastewater management systems in the northeast of the Australian state of New South Wales (NSW) for over a decade. This paper summarises some of the practical and research findings that have come to light in that time. Experience with various aspects of reed bed structure is discussed. A study of the evaporative performance of four small beds planted with Phragmites australis yielded an annual crop factor of 2.6. A total of 28 studies on reed beds treating a variety of commonly encountered wastewater streams yielded the following mean pollutant removal efficiencies: total suspended solids (TSS) 83%, biochemical oxygen demand (BOD) 81%, total nitrogen (TN) 57%, total phosphorus (TP) 35% and faecal coliforms (FC) 1.9 logs. The reed bed is becoming the preferred on-site technology for removing TN and BOD and polishing TSS from primary settled domestic wastewater. Sizing beds for a residence time of approximately five days has become standard practice. A study of six reed beds found six different species of earthworm present, mainly Perionyx excavatus (Indian Blue). A mesocosm experiment subsequently showed that the worms were translocating clogging material from the substrate interstices to the surface of the bed thereby indicating a possible method for prolonging reed bed life.

Animals↗
PubMed2005

The effect of nitrogen loading on on-site system design: a model for determining land application area size.

Designers of on-site wastewater management systems have six opportunities to remove pollutants of concern from the aqueous waste stream before it reaches ground or surface waters. These opportunities occur at source, at point of collection (primary treatment), secondary treatment, tertiary treatment, land application and buffers. This paper presents a computer based model for the sizing of on-site system land application areas applicable to the Lismore area in Northern New South Wales, a region of high rainfall. Inputs to the model include daily climatic data, soil type, number of people loading the system and size of housing allotment. Constraints include allowable phosphorus export, nitrogen export and hydraulic percolation. In the Lismore area nitrogen is the nutrient of most concern. In areas close to environmentally sensitive waterways, and in dense developments, the allowable annual nitrogen export becomes the main factor determining the land application area size. The model offers system designers the opportunity to test various combinations of nitrogen attenuation strategies (source control, secondary treatment) in order to create a solution which offers an acceptable nitrogen export rate while meeting the client's household and financial needs. The model runs on an Excel spreadsheet and has been developed by Lismore City Council.

Filtration↗
PubMed2003

Seasonal variation in phosphorus removal processes within reed beds--mass balance investigations.

The phosphorus (P) removal processes in two pairs of High and Low Loaded reed beds were investigated during five periods within a 27-month study. The uptake/release of P was measured in seven mass balance compartments. With the exception of the first year of operation, the reed beds consistently removed over 96% of the influent P load, with total phosphorus (TP) concentrations being reduced from 0.5 mg/L to generally less than 0.005 mg/L across the range of loading rates and seasons studied. During the first year, uptake by Phragmites australis accounted for greater than 75% of P removed, and was equally distributed between above and below-ground biomass. During the second and third years, three seasonal stages were identified in the uptake and cycling of P by P. australis. A period of rapid above-ground growth and uptake occurred during spring fuelled partly by P reserves accumulated in rhizomes during the previous year. During summer, uptake by above-ground biomass was governed by the influent P loading rate, while the amount of P held in below-ground biomass remained relatively stable. During autumn and winter, P appeared to be translocated from senescent shoots to reserves in the rhizomes. Approximately 85% of the below-ground biomass P occurred in the top 20 cm of the substrate. Gravel fixation increased in importance from 12% in the first year to approximately 30% of P removed in the second year, with a highly significant correlation between the influent P loading rate and P fixed by the gravel. The weakly-bound P fraction from a sequential extraction was the dominant form of P fixed by the gravel. HCI extracts were inappropriate for the examination of sorption processes as they dissolved large amounts of mineral P from within the basaltic gravel. The bottom 30 cm of the substrate became the most important site for gravel fixation during the second year. Incorporation of P into the detritus/microbiota/other compartment increased after the first year to become one of the most important P removal processes, probably consisting mainly of leaf litter and slowly accreted organic sediments.

Ecosystem↗
PubMed2003

Nitrogen removal from domestic effluent using subsurface flow constructed wetlands: influence of depth, hydraulic residence time and pre-nitrification.

This paper describes two studies into the BOD and TN removal performance of horizontal subsurface flow wetlands (reed beds) in subtropical Australia. The aim of the first study was to determine the influence of HRT and vertical position on BOD and TN concentration and removal performance in a 0.5 m deep reed bed (System 1) by taking samples from three levels (or layers) in the water column at five points along the length of the bed. The aim of the second study was to investigate the TN removal performance of a treatment train consisting of a vertical flow intermittently dosed sand filter preceding a reed bed (System 2). Both systems were dosed with primary settled municipal wastewater (BOD 194 mg L(-1); TN 49 mg L(-1)). System 1 achieved a TN load removal of 58% under a HLR of 22 mm day(-1) (HRT 10.5 days), producing effluent BOD concentrations consistently less than 8 mg L(-1). There was no significant difference in BOD attenuation rate between the three layers. While there were differences in both the nitrification and denitrification rates between the three layers, the TN concentration was found to decline steadily in all layers up to an HRT of 8.7 days. System 2 reduced TN influent load by 33%, less than half of which was removed by the reed bed. The lack of substantial TN removal within this reed bed was attributed to the low concentrations of BOD and consequent lack of dissolved organic carbon to drive the denitrification process.

Australia↗
PubMed2001

DNA dinucleotide evolution in humans: fitting theory to facts.

We examine length distributions of approximately 6000 human dinucleotide microsatellite loci, representing chromosomes 1-22, from the GDB database. Under the stepwise mutation model, results from theory and simulation are compared with the empirical data. In both constant and expanding population scenarios, a simple single-step model with parameters chosen to account for the observed variance of microsatellite lengths produces results inconsistent with the observed heterozygosity and the dispersion of length skewness. Complicating the model by allowing a variable mutation rate accounts for the homozygosity, and introducing a small probability of a large mutation step accounts for the dispersion in skewnesses. We discuss these results in light of the long-term evolution of microsatellites.

Chromosomes, Human↗
PubMed2001

On-site domestic wastewater treatment by reed bed in the moist subtropics.

This paper summarises the results of studies on four subsurface flow wetlands (reed beds) located in the moist sub-tropical north eastern corner of the Australian state of New South Wales. The reed beds, which are subjected to a variety of effluent types, all have a gravel substrate planted with Phragmites australis. All four units were found to maintain satisfactory treatment performance year round. Mean removal efficiencies ranged from 56% to 90% (SS), 70% to 93% (BOD), 38% to 66% (TN), 87% to 99.8% (Faecal coliforms), and 42% to 70% (TP--with one seasonal result of 0% for the eight year old unit) for the four reed beds. After eight years in operation the oldest reed bed was showing signs of phosphorus saturation with outlet TP concentrations exceeding inlet concentrations on some occasions. The youngest reed bed studied appeared to be operating efficiently after five months. A summer water balance on one of the reed beds revealed an average crop factor of 1.6 and a moisture loss to atmosphere of 40% of influent flow. Treatment performance (particularly for TN and SS) was found to be negatively correlated with rainfall during one study. The paper discusses the implications of the above results for on-site system designers and regulators and identifies areas for further investigation.

Biodegradation, Environmental↗
PubMed2001

The removal of nutrients from plant nursery irrigation runoff in subsurface horizontal-flow wetlands.

In New South Wales (NSW) Australia, the recent introduction of legislation to control runoff and charge for water used in agricultural production has encouraged commercial plant nurseries to collect and recycle their irrigation drainage. Runoff from a nursery typically contains around 6 mg/L TN (> 70% as NO3), 0.5 mg/L TP (> 50% as P04), and virtually no organic matter (BOD < 5 mg/L; DOC < 20 mg/L). As a result, algal blooms frequently occur in storage dams. This paper describes a study evaluating the effectiveness of subsurface flow wetlands in the removal of nutrients from nursery runoff on the sub-tropical northern coast of NSW, Australia. Four experimental subsurface flow wetlands (1 m x 4 m x 0.5 m water depth) were planted with Phragmites australis in April 1999. TN and TP load removals were > 84% and > 65% respectively at HRTs of between 5 and 2 days, with the majority of out-flowing TN and TP being organic in form. Internal generation of organic N and P resulted in persistent background levels of 0.45 mg/L TN and 0.15 mg/L TP in the reed bed effluent. TN, NH4 and TP removal was affected by HRT (P < 0.05). Greater than 90% load removal of NH4, NO2, NO3 and Ortho-P was achieved at all HRTs, with outlet concentrations generally < 0.01 mg/L for all. For TN, a strong relationship existed between removal rate (g/m2/day) and loading rate (r2 = 0.995), while a weaker relationship existed for TP (r2 = 0.47). It is estimated that a 1 ha nursery would require a reed bed area of 200 m2 for a 2 day HRT.

Agriculture↗
PubMed1998

Use of omental pedicle grafts in the management of non-healing axillary wounds in 10 cats.

A retrospective analysis of the clinical case histories of 10 domestic shorthaired cats that underwent omentalisation, using a vascular pedicle of greater omentum, of chronic non-healing axillary wounds was carried out. Wounds were debrided and closed in a primary fashion following omentalisation. The cats had undergone a modal number of three previous repair attempts over a three- to 18-month period (mean 11 months) before referral. Further dehiscence occurred in eight cases, requiring a modal number of one further attempt at closure of the wound. Other complications included incisional herniation (two cats), serous exudate from the axillary wound (two cats) and paracostal abscessation (one cat). Long-term cure was achieved in seven of the 10 cases, with wounds finally having healed at a mean of 24 days post-omentalisation. Chronic axillary wounds are particularly difficult to treat and there are no reports of consistently successful techniques for their repair. This report suggests that omentalisation of these wounds may be a step towards such a repair procedure.

Animals↗
PubMed1995

Relationship between blood lactate concentrations and ionized calcium, glucose, and acid-base status in critically ill and noncritically ill patients.

OBJECTIVE: To determine the relationships between circulating blood lactate concentrations and several biochemical variables including ionized calcium, glucose, pH, and acid-base status in critically ill and noncritically ill patients. DESIGN: A prospective, cohort study. SETTING: The critical care research laboratory, intensive care unit (ICU), emergency room (ER), and general ward of a 466 bed university-affiliated hospital. PATIENTS: Three-hundred thirty-four critically ill and noncritically ill patients. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: Circulating blood lactate concentrations, ionized calcium concentrations, blood glucose, pH, and base deficit values were simultaneously determined in blood samples from various patient populations. Descriptive data and physiologic parameters were also recorded. Circulating lactate and ionized calcium determinations were performed simultaneously in 334 whole blood samples from 334 subjects. There was neither a statistically significant nor clinically relevant correlation between circulating lactate concentrations and ionized calcium concentrations when lactate values were < or = 2 mmol/L (p = 0.8962, r2 = .01) or when lactate values were > 2 mmol/L (p = .3697, r2 = .09) in a heterogeneous patient population. Our study populations included five subject groups: a) nonhypotensive ICU patients (n = 93), b) nonhypotensive ER patients (n = 85), c) nonhypotensive general ward patients (n = 44), d) hypotensive patients from the ICU, ER, and general wards (n = 39), and e) normal controls (n = 73). There was neither a statistically significant nor clinically relevant correlation between circulating lactate concentrations and ionized calcium concentrations in each of the five populations studied for lactate values either < or = 2 mmol/L or > 2 mmol/L. We studied the relationship between circulating lactate concentrations and blood glucose concentrations (n = 334 patients), arterial pH and base deficit (n = 163 patients), and venous pH and base deficit (n = 171 patients). Statistically significant, but perhaps not clinically relevant correlations were observed when comparing circulating lactate values with blood glucose values (p = .0330, r2 = .12), arterial pH (p = .0007, r2 = .26) and base deficit from arterial specimens (p = .0014, r2 = .25). There were neither statistically significant nor clinically relevant correlations when comparing circulating lactate concentrations with venous pH (p = .9098, r2 = .01) or base deficit determined from venous blood specimens (p = .1365, r2 = .11). CONCLUSIONS: a) There is neither a statistically significant nor clinically relevant relationship between whole blood lactate concentrations and ionized calcium concentrations when studying patients with or without hyperlactatemia. b) Although there is a statistically significant correlation between circulating lactate concentrations and blood glucose concentrations, arterial pH or arterial base deficit, such associations do not appear to be clinically important.

Acid-Base Equilibrium↗
PubMed1994

The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations.

OBJECTIVE: To determine the validity and clinical importance of a newly developed amperometric, enzymatic, substrate-specific electrode for the rapid measurement of circulating lactate concentrations. DESIGN: A prospective multiexperiment study. SETTING: The critical care medicine research laboratory, intensive care unit (ICU), emergency department (ED), and general wards of a university-affiliated hospital. PATIENTS: A total of 1218 patients and control subjects were studied on one or more occasions. INTERVENTIONS: Blood lactate concentrations, descriptive data, physiological parameters, and outcome results were determined in various patient populations. MAIN OUTCOME MEASURES AND RESULTS: Experiment 1: Lactate determinations performed with the new substrate-specific electrode were compared with two laboratory reference methods. Blood samples from 80 ICU patients and 165 ED patients formed the basis of this first experiment. There was excellent agreement between the test instrument and the two reference methods as reflected by bias (with reference method 1, 0.19 mmol/L; reference method 2, 0.09 mmol/L), precision (with reference method 1, +/- 0.47 mmol/L; reference method 2, +/- 0.34 mmol/L), and correlation data (with reference method 1, r = .92; reference method 2, r = .98). Experiment 2: The new test microchemistry instrument was used to analyze blood samples from 927 patients. The mean (SE) blood lactate concentrations in the various patient populations were 1.26 (0.04) mmol/L for control subjects (n = 85), 1.52 (0.03) mmol/L for general ward patients (n = 489; P < .001 vs normal subjects), 2.34 (0.15) mmol/L for ICU patients (n = 180; P < .001 vs normal subjects and general ward patients), and 2.44 (0.15) mmol/L for ED patients (n = 173; P < .001 vs normal subjects and general ward patients). None of the normal subjects and only one (0.2%) of 489 nonhypotensive general ward patients had a blood lactate value greater than 4 mmol/L. Circulating lactate concentrations greater than 4 mmol/L were 98.2% specific in predicting the need for hospital admission in patients presenting to the ED. Furthermore, lactate concentrations greater than 4 mmol/L were 96% specific in predicting mortality in hospitalized nonhypotensive patients. Experiment 3: Blood samples from 46 hypotensive ICU and ED patients and from 353 nonhypotensive ICU and ED patients (the latter samples were derived from experiment 2) were analyzed. A statistically significant difference was noted between the mean (SE) lactate concentration in hypotensive patients in the ICU and ED (4.75 [0.75] mmol/L) when compared with nonhypotensive ICU and ED patients (2.28 [0.10] mmol/L; P < .001). Furthermore, blood lactate values greater than 4 mmol/L were 87.5% specific in predicting mortality in hypotensive patients. CONCLUSIONS: Lactate determinations performed using the new test instrument are precise and accurate. Blood lactate concentrations greater than 4 mmol/L are unusual in normal and noncritically ill hospitalized patients and warrant concern. In hospitalized (non-ICU) nonhypotensive subjects, as well as in critically ill patients, a blood lactate concentration greater than 4 mmol/L may portend a poor prognosis.

Blood Chemical Analysis↗
PubMed1992

Breech extraction of low-birth-weight second twins: can cesarean section be justified?

The outcomes of 54 breech-extracted second twins weighing between 750 and 2000 gm were compared with the outcomes of their siblings and of 43 sets of twins delivered by cesarean section for malpresentation. Vaginally delivered first twins had fewer days of mechanical ventilation and oxygen therapy than their breech-extracted siblings (p = 0.004). There were no significant differences in any measures of neonatal outcome when breech-extracted twins were compared with second twins delivered by cesarean section. We conclude that routine cesarean section is not justified for nonvertex second twins expected to weigh less than 2000 gm.

Breech Presentation↗
PubMed1990

Comparison of three assays for genetic effects of antineoplastic drugs on cancer patients and their nurses.

Three assays have been compared for their ability to detect genetic damage caused by antineoplastic drugs in cancer patients and possible damage in the nurses who administered these drugs. The assays were sister chromatid exchanges (SCE) and chromosomal aberrations in peripheral blood lymphocytes, and the Salmonella/mammalian microsome assay on urine. Three comparisons were made: 1) patients before versus after treatment; 2) the administering nurses immediately after their work period versus after a few days off that followed (work and off-work); 3) the exposed nurses versus other nurses who did not administer antineoplastic drugs (controls). The SCE assay detected the treatments in all eight patients from whom complete data were obtained, and was positive in two nurses with a long history of smoking. The Salmonella/mammalian microsome assay detected eight of ten treatments in patients but failed to detect smokers. Four of nine patients receiving treatment were detected by the analysis of chromosomal aberrations. The SCE assay did not distinguish between the work and off-work samples in either the exposed or control nurses. The exposed nurses, as a group, had slightly fewer SCEs than the controls due to the two smokers detected in the latter group. Chromosomal aberration was the only assay which showed significant difference between the two samples of the exposed nurses and, consequently, between the exposed and control nurses. These differences, however, arose primarily from a higher frequency of aberrations found among the exposed nurses in samples taken after a few days away from work, rather than at the end of their work period. There is no evidence that the increase was connected to occupational exposure.

Adult↗
PubMed1977

Barium meal appearance simulating superficial ulceration.

Five cases of diffuse gastric spiculation seen on single contrast barium meal examination are reported. This appearance may spuriously suggest superficial mucosal ulceration in cases in which no evidence of this is found endoscopically or histologically. This radiological appearance may be due to filling of the grooves between the areae gastricae and may thus represent a normal anatomical variant.

Adult↗