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Biomedical subjects

L Davies

Publications and source records attributed to L Davies.

At least 127 records · Page 7Linked to original sources

The evaluation of NIMROD, a community-based service for people with mental handicap: revenue costs.

The cost implications of moving from a system of services for people with mental handicaps centred on large institutions to a network of community-based services are not precisely known. The provision of the NIMROD service in a part of Cardiff, with its aim not only to meet the residential needs of adults comprehensively by providing a number of houses in the community but also to develop a support service to people living in their family home, gave an opportunity to investigate and report the revenue costs of a number of service elements with respect to a defined total population. The residential costs of intensively staffed houses in 1986-87, varying in size from two to six places, were found to range between pounds 16,473 and pounds 23,319 per person per year. With the addition of community support costs, such as the provision of day services, the total costs of care per resident averaged pounds 21,708; range, pounds 18,883-pounds 26,009. These compared to the total costs in a minimally staffed house of pounds 9,678 per resident. The costs of community support services for people living in their family homes averaged pounds 5,614 inclusive of DSS benefits, of which pounds 1,743 was accounted for by the NIMROD domiciliary support service, office base and administrative overheads. The residential costs reported were compared to other cost data in the literature. The study supports previous conclusions that there is little evidence of diseconomy attached to small scale per se but that the way staffing levels and therefore staff costs are determined is critical. No evidence was found in this study to link greater cost to better quality.

Capital Expenditures↗

Warning signals for malnutrition in the elderly.

Aging and disability are often assumed to coexist in Western society. Nevertheless, most elderly people live in noninstitutional settings. Monitoring and improving the nutritional integrity of the elderly could play a part in helping them remain healthy and independent. A community-based approach to the prevention of malnutrition in elderly people has been developed. This approach teaches warning signals for malnutrition to care providers who are in contact with elderly men and women. Care providers learn to recognize a group of circumstances (warning signals) that could have a negative impact on an elderly person's nutritional status. Examples of risk factors are given, and the interplay between risk factors and warning signals is discussed as well as their combined application. Practical steps for simple intervention are suggested. The dietitian is the nutrition educator and coordinator of this service.

Aged↗

Risk and selection processes between the general and the specialty mental health sectors.

This paper examines risk, defined as the threat of danger or disruption, as a contextual concept important for understanding patterns of patient selection and referral. We explore the hypothesis that risks associated with mental disorder, as represented by factors such as thoughts about suicide or problems associated with drinking, increase the probability of referral of patients receiving mental health care from general medical practitioners to the specialty mental health sector. Interview and claims data from the RAND Health Insurance Experiment, a large experimental study of coinsurance, are used to examine referral processes over a five-year period. Risk, and especially a measure of suicide thoughts, increase the probability of referral to specialty care. Women and persons with higher education are more likely to use specialty services; older persons are less likely to use such services. Understanding referral requires attention to the behavioral contingencies and illness behavior surrounding the presentation of mental disorder.

Educational Status↗

Mental effort and elaboration: effects of accessibility and instruction.

The present study examined the effects of accessibility to relevant schematic knowledge for elaboration in the associative learning of noun pairs. Fifth-grade participants performed two simultaneous tasks--associative learning and finger tapping--so that the mental effort demands of elaborating pairs that varied in accessibility could be estimated. The mental effort expended during the creation of sentence elaborations was greater for inaccessible pairs than accessible pairs. This accessibility difference was not observed when subjects were provided with the pair members in sentences. These findings confirm information-processing analyses of the elaboration process and support a knowledge-base interpretation of developmental differences in elaboration effort.

Attention↗

In vitro embryo culture in the production of identical merino lambs by nuclear transplantation.

This study examined the viability of embryos developed in vitro from 8- to 16-cell stage blastomeres fused with enucleated oocytes. Of 209 blastomeres recovered and subjected to manipulation and electrofusion procedures, 190 (91%) fused successfully, with 86 (45%) of those undergoing cleavage up to the 4- to 16-cell stage when cultured for 66 h in a synthetic oviduct fluid medium. The viability of the embryos was examined by transferring them to recipient ewes and determining the ewes' pregnancy status by ultrasound on Day 45. Of 86 embryos transferred, 14 developed to fetuses in 8 of the 36 recipients, including four sets of identical twins and one set of quads. In contrast, with uncultured and unmanipulated embryos, 15 fetuses developed from 19 embryos transferred at a similar stage of development. The viability of embryos derived from manipulated zygotes cultured in vitro was comparable to that previously reported for studies employing in vivo culture, indicating the potential of in vitro culture systems based on a simple medium for nuclear-transplantation embryos.

Animals↗

Confidants and companions in later life: the place of family and friends.

Responses from a sample of 400 older persons were used to determine the relative importance of various family members (spouse, children, siblings, other relatives) and friends in the confidant and companion networks of later life. Significant differences exist among older persons (based on gender, marital status, and availability of children) in the salience of these ties as confidants and companions. There are also major differences in the configuration of the confidant vs companion networks. These variations are discussed in the context of the hierarchical-compensation, task specificity, and functional specificity of relationships models of support. The findings demonstrate that a distinction regarding availability of kin must be made among those who never had a particular kin tie (e.g., the childless and single), those who have lost a previous tie (e.g., the widowed), and those whose tie lives far away.

Aged↗

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.

A double-blind, placebo-controlled trial was conducted to study the effects of over-the-counter analgesic/antipyretic medications on virus shedding, immune response, and clinical status in the common cold. Sixty healthy volunteers were challenged intranasally with rhinovirus type 2 and randomized to one of four treatment arms: aspirin, acetaminophen, ibuprofen, or placebo. Fifty-six volunteers were successfully infected and shed virus on at least 4 days after challenge. Virus shedding, antibody levels, clinical symptoms and signs, and blood leukocyte levels were carefully monitored. Use of aspirin and acetaminophen was associated with suppression of serum neutralizing antibody response (P less than .05 vs. placebo) and increased nasal symptoms and signs (P less than .05 vs. placebo). A concomitant rise in circulating monocytes suggested that the suppression of antibody response may be mediated through drug effects on monocytes and/or mononuclear phagocytes. There were no significant differences in viral shedding among the four groups, but a trend toward longer duration of virus shedding was observed in the aspirin and acetaminophen groups.

Acetaminophen↗

Species composition and larval habitats of blowfly (Calliphoridae) populations in upland areas in England and Wales.

1. Bait trapping at upland sites in England and Wales, mainly at 400-700 m altitude, showed that Calliphora vomitoria L. usually outnumbered all other blowflies. C.vicina R.-D., C.loewi End. and C.alpina Zett were usually present in much lower numbers, with the last-named occurring at north Pennine sites, but being replaced by C.subalpina Ringd. at a south Pennine (Peak District) and a Welsh site. Catches normally included Cynomya mortuorum L., and Phormia terraenovae R.-D. was present at about half of the sites, usually in low numbers. 2. Lucilia spp. (predominantly L.caesar L.) were often abundant in catches at 300-430 m, but were absent or rare at 500 m and above, except at certain times. 3. Exposure of mouse carcasses at north Pennine upland sites, and rearing of adults from them, showed that they were colonized in a very indeterminate variable way by C.vicina, C.loewi, C.alpina and Cy.mortuorum, with dominant and subsidiary species varying in identity and numbers within periods as short as 3 weeks. 4. Sampling of large carcasses, i.e. hill sheep casualties in Co. Durham, showed that C.vomitoria predominated as the blowfly colonist, with C.vicina and Cy.mortuorum in much smaller numbers.

Animals↗

Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs.

This study assesses the economic benefits of misoprostol in the prophylaxis of gastric ulcers larger than 0.3 cm in patients with osteoarthritis receiving non-steroidal anti-inflammatory drugs. Independent epidemiological data were obtained for patients in Scotland and the West Midlands. Co-diagnosis of arthritis with gastric ulcer recorded in the routine data was substantially less (4% Scotland, 10% West Midlands) than the 21% found at case review. These data were combined with cost and patient management data in a decision analysis model to explore whether prophylactic use of misoprostol altered substantially the average cost of managing gastric ulcer. Using conservative assumptions and a daily dose of 400 micrograms, cost savings per patient to the National Health Service of 5-8 pounds over a 3-month period are expected in the groups of patients studied, while at the 800 micrograms dose there would be a net cost of 23-25 pounds. Sensitivity analysis showed that under many assumptions misoprostol is expected to be cost saving or cost neutral.

Alprostadil↗

Opportunities for better health in the elderly through various forms of mass catering.

Mass catering systems can be used to provide food for the elderly in their own homes, in luncheon clubs, in residential homes and similar establishments and in hospitals. Food and service should be not only nutritionally correct, but also pleasing and acceptable. Eating contributes to psychological and social as well as physical health. Because of limited budgets, strict control of suppliers must be maintained with clear specifications of all items. Staff responsible for menu planning and food service must be adequately trained. Meals should be enjoyable as well as healthy.

Aged↗

Non-isotopic hybridization assays for bacterial DNA samples.

The background problem associated with the use of streptavidin in detecting biotin-labelled probes hybridized to DNA in crude bacterial extracts has been investigated. We have found that streptavidin binds specifically to a limited number of polypeptides which are difficult to remove by rapid extraction processes. Altering the hybridization and detection protocols results in a marked but not complete reduction of non-specific background in streptavidin-biotin assays. Complete elimination of non-specific background was achieved only when streptavidin was replaced with antibodies for the detection of biotinylated or sulphone-modified probes. The antibody-sulphone and streptavidin-biotin dot blot assays described here require 4.5-5 hours to perform and can detect DNA sequences in samples extracted from 2 x 10(7) cells or fewer.

Bacterial Proteins↗