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Biomedical subjects

L David

Publications and source records attributed to L David.

At least 307 records · Page 17Linked to original sources
PubMedDate not supplied

[Calcitonin-cells in the thyroid of the human fetus. Immunocytochemical study (author's transl)].

Calcitonin (CT)-cells were detected, by using an anti-human calcitonin serum (hCT), in the thyroid of the normal and anencephalic human fetuses. The first CT-cells were observed at 14 weeks of gestation. The CT-cells were at first isolated afterwards were appeared in parafollicular localization. The CT-cells were only observed in the middle of the upper or medium third or the lateral lobes, along the central axis of the lobes. No CT-cells were detected in the isthmic region or in the inferior third of the lobes. CT-cells were also seen in the thyroid of the anencephalic fetuses. The specificity of the immunocytological reaction was ascertained after incubation of anti-hCT serum with homologous or heterologous antigens: after incubation of the anti-hCT serum with hCT, the immunocytological reaction was disappeared, but no modification of the reaction was noted after incubation with somatostatin, T4 or parathormone. The CT appeared precociously in the thyroid of the human fetus and their localization was the same that in the older subjects.

Calcitonin↗
PubMedDate not supplied

[Renal involvement in the Laurence-Moon-Bardet-Biedl syndrome. Apropos of 3 cases].

Three cases of Laurence-Moon-Bardet-Biedl (LMBB) syndrome with renal involvement characterized by tubulo-interstitial lesions are reported. Caliceal deformations were noted on urography. From 55 additional cases found in the literature the main characteristics of the renal disease in LMBB are defined : impairment of renal concentration is present in 36 % of the cases, and urographic abnormalities, mainly dysplasic features and multiple cystic formations on the calices, in 90 %; tubulo interstitial lesions are the most frequent histological finding. The renal involvement lead to chronic renal insufficiency responsible for the death of 60 % of the patients. Renal disease appears therefore as the sixth cardinal features of the LMBB syndrome and makes this syndrome as an entity close to other hereditary disorders with renal abnormalities as Alström syndrome.

Child↗
PubMedDate not supplied

[Anomalous aortic origin of the left coronary artery. Apropos of sudden death in an adolescent].

A 16 year-old adolescent boy died suddenly after an effort. Autopsy showed an anomalous origin of the left coronary artery from the right sinus of Valsalva. During the 3 years preceding his death, this patient presented symptoms that were apparently induced by physical efforts: digestive troubles, chest pain and syncopes. The latter resulted in the erroneous diagnoses of epilepsy, then hypervagotonia. The incidence of this kind of malformation, the mechanism of death and the necessary investigations are discussed. Thorough autopsy should always be performed in order to elucidate the cause of sudden death in young patients.

Adolescent↗
PubMedDate not supplied

Causal evaluation of impact of support workshop for HIV+ men.

A program logic model was used to design and evaluate a support workshop for men infected with HIV. The model identified three proximal outcomes leading to the ultimate goal of motivating participants to initiate ongoing support relationships. Path analysis was used to evaluate the workshop. The findings indicated the most important motivator to initiating ongoing support was the awareness among participants of the need to talk about their HIV status and risk of transmission and their feeling capable to do so. The proximal outcomes which contributed to this impact were: recognition of their own needs from listening to testimonials by others, developing awareness and skills by engaging in role plays, and learning options for discussion by participating in a sexual issues group. The workshop findings demonstrated the benefits of developing a pre-program logic model and using causal evaluation to understand factors determining impact.

Adaptation, Psychological↗