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Biomedical subjects

L Dann

Publications and source records attributed to L Dann.

10 recordsLinked to original sources
PubMed2001

Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents.

We sought to determine whether the intracellular activation of zidovudine (ZDV) varied over time and with previous antiretroviral exposure in human immunodeficiency virus-infected individuals and to examine whether there is an association between virological responses and intracellular phosphorylation. A total of 23 patients (12 treatment naïve, 11 previously treated with ZDV) who commenced ZDV as part of dual nucleoside therapy were prospectively monitored for 12 months or until withdrawal from the study. No association was observed between virological responses at 2 weeks and 3 months and ZDV phosphorylation. The mean intracellular concentrations of ZDV mono-, di-, and triphosphates did not change significantly over time or with previous ZDV exposure. The rate of formation of total ZDV phosphates was increased in patients with CD4 counts <100 cells/mm(3). Previous reports from in vitro cell culture experiments or cross-sectional cohort studies suggesting alterations of ZDV phosphorylation over time are not confirmed by this longitudinal study.

Adult↗
PubMed1994

Acute pneumothorax.

Pneumothorax may be spontaneous or can occur as a complication of chest trauma. Patients present with a wide range of symptoms, the severity of which may not correlate well with the degree of pneumothorax. Classification and current therapies are presented here.

Acute Disease↗
PubMed1994

Severe epistaxis.

Epistaxis is a common condition usually requiring only simple treatment. Occasionally, severe epistaxis may present as a medical emergency. The classification and management of this condition are presented here.

Adult↗
PubMed1994

Acute anaphylaxis.

Acute anaphylaxis is a potentially life-threatening condition. It must be recognised early and treatment instituted promptly. Localised, severe allergic reactions and generalised anaphylactoid reactions should be treated in the same way as acute anaphylaxis.

Acute Disease↗
PubMed1994

Maintaining an airway.

Airway maintenance is a vital skill that is often poorly managed due to the failure to observe simple principles. Clearing the airway is essential before the use of airway adjuncts. This always must be in addition to adequate ventilation.

Emergencies↗
PubMed1980

Cystic fibrosis.

Explore the source record for details and available documents.

Cystic Fibrosis↗
PubMed1979

Alcohol intake in selected lines of mice: importance of sex and genotype.

Mice selected by McClearn and Kakihana for differences in ethanol-induced sleep time were used as subjects. In Experiment 1, mice from the long-sleep (LS) and short-sleep (SS) lines were offered a choice of water or solution GS consisting of 3% glucose and .16% sodium saccharin (w/v); or a choice of water or solution GS + E that contained GS solution plus 4% ethanol (w/v). In Experiment 2, mice from the first experiment were provided with a three-way choice among water, solution GS, and solution GS + E. In both experiments, SS mice (alcohol-insensitive) consumed more GS + E than LS mice (alcohol-sensitive). In addition, female mice drank considerably more GS + E solution than male mice. Thus, consumption of sweetened ethanol in both a two-way choice (water and GS + E) and a three-way choice (water, GS, and GS + E) is dependent on both genotype and sex. High genetic sensitivity to ethanol was associated with low consumption, and vice versa. Although females consumed more alcohol than males, famales of these lines have not been previously found to show lower sensitivity to acute alcohol administration.

Alcohol Drinking↗
PubMed1973

Excretion of enterochelin by exbA and exbB mutants of Escherichia coli.

Escherichia coli mutants that are insensitive to colicins B and I hyperproduce and excrete the iron chelator enterochelin, which is an inhibitor of these colicins. These mutants are classified as exbA and exbB. The exbA mutants are chromium sensitive and require iron for growth, and the mutations are located in the tonB region at min 25 of the E. coli chromosome. tonB mutants in which the genome of phage lambda is inserted into the bacterial chromosome within the tonB gene also exhibit enterochelin excretion. The exbB mutants require methionine and probably result from deletions which are located between min 56 and 58. Colicin insensitivity, enterochelin excretion and methionine auxotrophy are recessive in exbB merodiploids. The methionine requirement of exbB strains is satisfied by cystathionine or homocysteine, and exbB mutants are sensitive to ethionine.

Chelating Agents↗