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Biomedical subjects

L Dall

Publications and source records attributed to L Dall.

33 records · Page 2Linked to original sources
PubMed1985

Effects of exopolysaccharide production by viridans streptococci on penicillin therapy of experimental endocarditis.

The influence of exopolysaccharide production by viridans streptococci on penicillin therapy of endocarditis was studied in rabbits with experimental aortic-valve endocarditis. Animals were first infected with penicillin-susceptible streptococci known to produce varying amounts of exopolysaccharide in cardiac vegetations. Treatment with procaine penicillin, 300,000 U every 12 hr, was begun one to two days after infection. After five days of therapy, animals infected with Streptococcus sanguis II and Streptococcus morbillorum, both vigorous exopolysaccharide producers, continued to have infected vegetations, while animals infected with Streptococcus salivarius and a different Streptococcus sanguis II, both deficient in exopolysaccharide production, had sterile vegetations. These findings indicate that failure to eradicate streptococci from vegetations correlates with exopolysaccharide production and that this property may be important in determining outcome of therapy.

Animals↗
PubMed1984

Escherichia vulneris: isolation and treatment.

We have described two cases of Escherichia vulneris wound infections resistant to ampicillin given orally, but susceptible to higher blood levels obtainable by parenchymal administration.

Adult↗
PubMed1984

Exopolysaccharide production by viridans streptococci in experimental endocarditis.

Light and electron microscopy with histochemical staining were used to estimate exopolysaccharide production by strains of viridans streptococci recovered from patients with endocarditis. Six strains were selected for study because they represented a wide range of in vitro polysaccharide production. By light microscopy, there was good agreement between three polysaccharide stains (ruthenium red, periodic acid-Schiff and calcifluor white) in the amount of glycocalyx produced, which ranged from minimal (0 to 1+) to maximal amounts (4+). Two strains selected for minimal (strain 1) and maximal (strain 6) in vitro exopolysaccharide production were studied after we used them to experimentally infect cardiac vegetations. Glycocalyx could be demonstrated surrounding organisms in cardiac vegetations, and the relative amounts produced were similar to those seen in vitro. Vegetations formed by glycocalyx-producing strains were also larger than those formed by glycocalyx-deficient strains. Viridans group streptococci which produce exopolysaccharide in vitro also do so within cardiac vegetations. The relationship of exopolysaccharide production to maintenance of endocardial infection is discussed.

Animals↗
PubMed1984

Emergence of multidrug-resistant Mycobacterium fortuitum during treatment.

We present a case of pulmonary infection with Mycobacterium fortuitum demonstrating the development of multidrug resistance during therapy with multiple drugs. Emergence of drug resistance in a previously sensitive M fortuitum has been described with single drug therapy, but never before with multiple drug treatment. Development of resistance in the setting of multiple drug therapy illustrates the importance of repeated susceptibility testing during therapy.

Carcinoma, Squamous Cell↗
PubMed1983

Chemotherapy for pulmonary tuberculosis. A short-course regimen and its rationale.

After years of declining incidence, pulmonary tuberculosis is increasing, owing in part to the influx of Asian refugees. An understanding of the tubercle bacillus and a knowledge of chemotherapy enable the physician to give adequate treatment. Short-course chemotherapy has been found to be 99% effective in clinical trials, leading the American Thoracic Society to recommend use of this mode of treatment.

Drug Therapy, Combination↗
PubMed1983

Acute renal failure secondary to myoglobinuria associated with Legionnaires' disease.

A case of nonfatal Legionnaires' disease was complicated by rhabdomyolysis, myoglobinuria, and acute nonoliguric renal failure. It was not determined whether the rhabdomyolysis was secondary to direct toxic effect of the organism or due to a circulating factor causing muscle necrosis. This case provides additional evidence that rhabdomyolysis with subsequent renal failure may be a serious complication of Legionnaires' disease.

Acute Kidney Injury↗
PubMed1983

Tuberculosis today.

Explore the source record for details and available documents.

Antitubercular Agents↗
PubMedDate not supplied

Poncet's disease: tuberculous rheumatism.

Poncet's disease is characterized by a polyarthritis that occurs during acute tuberculosis infection in which no mycobacterial involvement can be found or other known cause of polyarthritis detected. It is a different entity from tuberculous arthritis, which is usually monoarticular and is caused by direct tuberculin infection. Poncet's disease remains a diagnosis of exclusion. Thirteen cases have been reported in the English-language literature since 1974. All patients who received the Mantoux test reacted positively, and 10 of 11 patients treated with antituberculous drugs had resolution of arthritis on therapy. Poncet's disease and erythema nodosum could be differing expressions of a common immunopathogenic response to tuberculin.

Adult↗
PubMedDate not supplied

Comparison of cefonicid and cefazolin for treatment of soft-tissue infections.

Cefonicid was compared with cefazolin for the treatment of serious infections of soft tissue. According to a randomized, prospective protocol designed to assign twice as many patients to cefonicid, 38 patients were treated with cefonicid and 19 patients, with cefazolin. Dosages used were 1.0 g once daily intramuscularly or intravenously for cefonicid and 0.5-1.0 g three times a day intramuscularly or intravenously for cefazolin. Clinical diagnoses included cellulitis (39 patients), abscesses (14), infected ulcers (3), and bursitis (1). Bacteriologic diagnoses included Staphylococcus aureus alone (8 patients), group A Streptococcus alone (13), combined S. aureus plus streptococci (8), viridans group streptococci alone (1), and mixed anaerobes (1). Gram-negative rods were isolated from 11 patients, all in mixed cultures with gram-positive species. For two patients, gram-negative organisms were thought to be etiologic. All 57 patients responded satisfactorily to treatment. Treatment with either drug was neither interrupted nor discontinued because of toxicity. Both cefonicid and cefazolin appear to be effective for the treatment of infections of skin and soft tissues. Cefonicid has the advantage of once-daily dosing.

Abscess↗
PubMedDate not supplied

Treatment of pulmonary sporotrichosis with ketoconazole.

Antifungal therapy that included ketoconazole failed in a 44-year-old woman with pulmonary sporotrichosis progressing slowly over a seven-year period. On the basis of this case and the modest amount of experience reported in the literature, ketoconazole does not appear to be effective in the treatment of pulmonary sporotrichosis.

Adult↗
PubMedDate not supplied

Stability of capsules containing omeprazole in enteric coated pellets.

The aim of the present study was to comparatively evaluate the stability of capsules containing 20 mg of Omeprazole, in enteric coated pellets, from seven pharmaceutical laboratories on Argentine market. The stability test was performed under the conditions indicated by the ICH: 40 degrees C, 75% HR, with and without light, during a six month period. The remaining content of Omeprazole, total percentage of impurities and percentage of released active principle in vitro, were determined by HPLC. The organoleptic characteristics of the pellets were visually examined. The results obtained at six months indicate that, from the seven products studied, four were found to have a content of Omeprazole higher than 90% of the labeled amount, in both lighting conditions tested, and also comply with the USP23 specifications with respect to the release in vitro. We conclude that the progressive darkening of the pellets indicates, qualitatively, the level of degradation of the product and that the stability of Omeprazole depends on the correct formulation and the primary container.

Anti-Ulcer Agents↗