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Biomedical subjects

L D Lowry

Publications and source records attributed to L D Lowry.

At least 91 records · Page 5Linked to original sources
PubMed1977

Safe use of epinephrine with halothane anesthesia.

A review of the anesthesia literature outlines safe limits for use of epinephrine with halothane anesthesia and adequate ventilation. Excluded from the safe category are patients with previous cardiac disease, hypertension, patients taking monoamine oxidase inhibitors and reserpine. Considered as safe is 10 milliliters of 1:100,000 epinephrine in 10 minutes and not more than 30 milliliters of 1:100,000 epinephrine per hour.

Adult↗
PubMed1976

C.A.T. scans.

Explore the source record for details and available documents.

Humans↗
PubMedDate not supplied

Angiomyolipoma of the nasal cavity: case report and review of the literature.

An unusual localization of intranasal angiomyolipoma is described in an adult male patient with no signs of tuberous sclerosis. The lesion was composed of mature fat cells, vascular spaces with lack of elastic tissue, and presence of bundles of mature smooth muscle cells. Antibodies to intermediate filaments revealed presence of vimentin and absence of desmin in both smooth muscle bundles and in vessel walls. A review of the literature has shown that this is only the third reported case of the angiomyolipoma of the nasal cavity, and some important differences between this entity and renal angiomyolipoma are described.

Angiomyolipoma↗
PubMedDate not supplied

Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group.

Between March 1973 and June 1979, patients with advanced operable squamous cell carcinoma of the supraglottic larynx or hypopharynx were randomly allocated to receive either preoperative radiation therapy (5,000 rad) or postoperative radiation therapy (6,000 rad). Patients with oral cavity or oropharynx lesions were randomly assigned either preoperative radiation, postoperative radiation, or definitive radiation therapy (6,500-7,000 rad), with surgery reserved for salvage if residual disease was present 6 weeks after completion of irradiation. Three hundred twenty patients were evaluable with a median follow-up of 60 months. Based on results in 277 patients across all four regions combined, locoregional control was significantly better for patients assigned to receive postoperative radiation therapy (65%) compared with those assigned to receive preoperative radiation therapy (48%, P = 0.04). This was due to a higher rate of both persistent and recurrent local and regional disease in the preoperative group. Survival also showed a trend to be better in the postoperative group (38%) compared with the preoperative group (33%, P = 0.10). Rates of severe surgical and radiation therapy complications were similar overall. Forty-three patients were evaluable for each of the three treatment regimens assigned to patients with oral cavity or oropharynx lesions. Due to the small number of patients available for this portion of the trial, the observed differences for overall survival (4-year percentage 33% overall; 30% preoperative, 36% postoperative, 33% definitive radiation therapy) and for locoregional control (45% overall; 43% preoperative, 52% postoperative, 38% definitive radiation therapy) were not statistically significant. The use of definitive radiation therapy with surgical rescue as an ethically justified alternative treatment for these tumors remains a question for further research.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Vagal paragangliomas: a report of nine cases.

Vagal paragangliomas are rare tumors of neural crest origin: fewer than 175 cases have been reported in the English literature. This slow-growing tumor occurs most often at the base of the skull in the parapharyngeal space, but may arise anywhere along the course of the vagus nerve and its branches. Nine clinical presentations and the surgical outcome in seven patients with vagal paragangliomas treated at our institution are reported. A review of the literature, emphasizing evaluation and treatment of these potentially fatal neoplasms, is discussed. Surgical removal is the treatment of choice with vagal tumors. Complications related to the ablation or injury of cranial nerves IX, X, XI, and XII are commonly seen. Surgical techniques that may prevent injury to these vital neural structures are outlined. The postoperative treatment of patients with impaired deglutition secondary to multiple cranial neuropathies is discussed.

Adult↗
PubMedDate not supplied

Current national trends in the posttreatment follow-up of patients with squamous cell carcinoma of the head and neck.

INTRODUCTION: Follow-up of individuals treated for a primary squamous carcinoma of the upper aerodigestive tract is critical because of the high risk of development of either recurrent disease or a new primary tumor. A mail survey of physicians actively practicing head and neck surgery was undertaken. MATERIALS AND METHODS: A multiple-choice survey was distributed to 400 members of the American Society for Head and Neck Surgery. Respondents indicated approach to post-treatment follow up. RESULTS: Surveys were returned from 290 members (73%). Routine monthly follow up is advocated by 73% of respondents during the first postoperative year. Patients are followed every 2 to 3 months in the second postoperative year by 90% of respondents. During postoperative years, 3 to 5 patients are seen every 4 to 6 months by 97% of respondents. All respondents see patients either semiannually or annually for the remainder of their lives. Sixty percent of respondents advocate annual screening chest radiographs, whereas 14% do not order routine chest radiographs. The overwhelming majority of respondents reserve barium swallow and computed tomographic (CT) scans for evaluation of symptomatic patients. Similarly, nuclear imaging is reserved for patients with specific symptoms or abnormal laboratory tests. Blood tests most frequently monitored include complete blood cell count (CBC) (43%), thyroid function test (22%), and liver function test (20%). Follow-up endoscopic evaluation under anesthesia is reserved for symptomatic patients by over 95% of respondents. CONCLUSION: These data demonstrate that head and neck surgeons rarely use supplemental studies other than chest radiograph during routine follow up. The authors speculate that routine chest radiograph may be valuable in screening for a second primary carcinoma. Techniques to screen for esophageal tumors remain contentious.

Audiometry↗
PubMedDate not supplied

Hydrostatic pressure measurement of endolymph and perilymph in the guinea pig cochlea.

Hydrostatic pressures of endolymph and perilymph were measured with a servo-micropipet system. The validity of the experiment was assessed by observation of endolymphatic pressure changes during and after 3 minutes of anoxia. Simultaneous recording of endocochlear DC potential confirmed the location of the electrode tip. Following verification of the efficacy of the system, measurements of endolymphatic or perilymphatic pressures were made in ten guinea pigs in which the middle ears had been filled with a saturated sodium chloride solution. Both endolymphatic and perilymphatic measurements showed gradual declines in pressure, with minimum pressure at 15 to 20 minutes and slow recovery during the next 20 minutes.

Animals↗
PubMedDate not supplied

Auditory 40-Hz responses in the guinea pig.

Auditory evoked potentials in response to tone bursts repeated at a rate of 40 per second (auditory 40-Hz responses) were studied in the guinea pig. The potentials, consisting of a sequence of 40-Hz waves with a periodicity of about 25 msec, were distributed widely over the skull, and the largest potentials were recorded from the vertex (midline) and the temporal area contralateral to the stimulated ear. Administration of pentobarbital did not affect the midline response but reduced the amplitude of the contralateral response. Investigations of the effects of acute lesions demonstrated that the auditory 40-Hz responses from the contralateral temporal area were eliminated by aspiration of the contralateral cerebral cortex, whereas the responses from the midline continued to appear after bilateral aspiration of the cerebral cortex. The response from the midline was maintained after bilateral aspiration of the inferior colliculi, and the basic 40-Hz rhythm was still observed after decerebration. These data suggest different generation areas for the midline and contralateral 40-Hz responses in the guinea pig.

Acoustic Stimulation↗