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Biomedical subjects

L D Dorr

Publications and source records attributed to L D Dorr.

106 records · Page 6Linked to original sources

Total hip arthroplasties in patients less than forty-five years old.

We studied the cases of eighty-one patients (108 total hip arthroplasties), ranging in age from fourteen to forty-five years, at an average of 4.5 years after the index operation and evaluated them with regard to six major factors: age, disease, Charnley category, prior operations, length of time since arthroplasty, and quality of the arthroplasty with regard to cementing technique and component position. After two to five years 78 per cent were satisfactory, but after five years or more only 72 per cent were satisfactory. Patients who were less than thirty years old had poorer results. Good technique yielded 93 per cent satisfactory clinical results. The patients in this study with the worst prognosis for success following total hip arthroplasty were less than thirty years old, had osteonecrosis or osteoarthritis as the primary disease, and had a less than optimum reconstruction. Patients who were alcohol-abusers or who had had a prior hip infection or a prior acetabular cup or femoral hemiarthroplasty also had a poor prognosis. Patients who had the arthroplasty for collagen disease or were thirty years old or older, or both, and had a good technical reconstruction had the best prognosis.

Adolescent↗

Aspirin prophylaxis for pulmonary embolism following total hip arthroplasty. An incidence study.

Although this study was performed on a relatively small number of patients undergoing total hip arthroplasty in conjunction with aspirin prophylaxis for postoperative pulmonary embolism, several important points are noted: the use of pre- and postoperative lung perfusion scanning can eliminate a 15% rate of false-positive diagnosis of pulmonary embolism, and pulmonary embolism occurred in approximately 8% of patients undergoing total hip arthroplasty in conjunction with aspirin prophylaxis, without fatality. This occurred despite the inclusion of high-risk patients. "Silent" pulmonary embolization occurred in 4.1% of these patients. Patients who have a history of a thromboembolism, a delayed postoperative course, and two or more risk factors for pulmonary embolism present, are at risk of developing a postoperative pulmonary embolism, despite aspirin therapy, and should be managed more aggressively, i.e., early detection or prophylactic anticoagulation therapy.

Adolescent↗

The functional cost of dislocation following total hip arthroplasty.

The consequences of dislocation following total hip arthroplasty were assessed using quantitative gait analysis. As a preliminary study, a review of 18 patients having undergone hip arthroplasty without dislocation provided as understanding of the improvement in gait in the first two years after surgery. Seven patients with a single dislocation and six patients with multiple dislocations were compared with patients matched according to age and preoperative gait characteristics and who experienced an uncomplicated recovery following hip arthroplasty. One year after surgery patients with a single dislocation could not be differentiated from the matched patients with respect to gait velocity and single limb support time. However, patients, with multiple dislocations walked significantly slower and had a significantly decreased single limb support time in the involved extremity than their respective matched patients.

Aged↗

Treatment of hip fractures in elderly and senile patients.

Hip fractures in elderly and senile patients are associated with a high incidence of morbidity and mortality. For this reason, restoration of function rather than restoration of the hip must be the first concern. In senile patients with intertrochanteric fractures, condylocephalic fixations is preferred because of the decreased infection rate. In patients with severe osteoporosis, bed rest with traction as needed for comfort may be preferable. Fractures of the femoral neck in this group are best treated with percutaneous pin fixation. In the elderly ambulatory patient with no more than minimal confusion, compression screw fixation with severe osteoporosis in these patients should have adjunctive use of methylmethacrylate. In this group, fractures of the femoral neck in our experience are better treated with a cemented endoprosthesis or total hip arthroplasty.

Aged↗

Platelet activity (malondialdehyde production) after orthopaedic surgery: the effect of aspirin.

Using a biochemical assay of the prostaglandin endoperoxide metabolite malondialdehyde, platelet activity was evaluated in 147 patients who were undergoing orthopaedic surgical procedures. Assays were performed before and after operation and the results were correlated with the type of operation, the sex of the patient, and the use of aspirin as an antiplatelet-aggregation agent. Postoperatively, statistically significant elevations of platelet activity were found in patients who were not taking aspirin, while highly statistically significant suppressions of this activity were found after total hip arthroplasties and other surgical procedures in patients who had received aspirin. Men and women had similar levels of suppression of platelet aggregability with aspirin.

Adult↗

Total hip arthroplasty in protrusio acetabuli of rheumatoid arthritis.

Thirty-five total hip arthroplasties done in twenty-five patients with protrusio acetabuli secondary to rheumatoid arthritis were reviewed. There was an average follow-up of 4.3 years, with a range of three to seven years. The results were rated as excellent or good in 66 per cent, fair in 26 per cent, and poor in 8 per cent. Although 100 per cent demonstrated cementbone interface demarcation around the acetabular component, only 10 per cent showed progression of the line of demarcation to two millimeters and one had acetabular loosening with migration. Eight per cent showed femoral loosening or subsidence; 8 per cent, calcar resorption; and 6 per cent, a receding cortex with cystic changes. Twenty-three per cent had nonunion of the greater torchanter after trochanteric osteotomy. Type-III cement-bone interface demarcation was present around the acetabular component was positioned one centimeter superiorly or medially beyond the anatomical position, as estimated by the method described. In thirteen hips in which the acetabular component was positioned within five millimeters of the anatomical position, no Type-III demarcation was present. Better fixation and position of the acetabular component is achieved by the use of a bone graft or a special titanium perforated-sheet mesh, or both, or by an acetabular shell. The use of three wires improved trochanteric fixation.

Arthritis, Rheumatoid↗

Pulmonary emboli followed total hip arthroplasty: incidence study.

We compared twenty-five total hip-arthroplasty patients with twenty-five patients who underwent other operations on the lower extremity, with regard to evidence of pulmonary embolism as determined preoperatively and postoperatively from lung perfusion scans, ventilation scans, and pulmonary angiography. Blood gases and serum enzymes also were studied. The over-all incidence of pulmonary embolism was 6 per cent, despite the absence of clinical evidence of that complication. Abnormalities in scans and blood studies were common preoperatively, so that the diagnosis often depended on the detection of additional abnormalities postoperatively.

Female↗

The effect of antibiotics, primary and secondary closure on clostridial contaminated open fracture wounds in rats.

In a study of experimentally induced open tibial or femoral fractures in rats, after either closing or leaving the wounds open, the animals were given: no antibiotic, cephalothin (Keflin), or penicillin. The rats with wounds closed primarily and receiving no antibiotics had the highest mortality rate (11 of 25) from experimentally produced clostridial myonecrosis. The lowest overall mortality rate (5 of 99) was found in the penicillin-treated groups. The higher mortality rate in the femur fracture groups was probably because of the large muscle mass of the thigh. The importance of ideal anaerobic conditions for producing experimental clostridial myonecrosis is emphasized.

Animals↗

The early management of open joint injuries. A prospective study of one hundred and forty patients.

A study of open joint injuries treated at the Los Angeles County-University of Southern California Medical Center from July 1969 through July 1973 showed that the vast majority of these injuries were at the knee. Three types of injury were identified: those associated with fractures, injuries without fracture, and gunshot wounds. All patients were treated with antibiotics, surgical débridement and irrigation, and installation of polyethylene tubes into the joint as a system of postoperative closed irrigation. The over-all infection rate was 2.1 per cent. The results of treatment indicate that the irrigation system can be a source of contamination. Our recommended treatment for open wounds in joints is wide-spectrum systemic antibiotics, surgical débridement, irrigation of the joint and soft tissues, and primary closure. Prolonged suction-irrigation treatment postoperatively should only be done for specific indications: excessive contamination or excessive tissue damage when the wound to the joint should be closed primarily.

Adult↗

Clinical review of the early stability of spine injuries.

One hundred fifteen cervical fractures, 51 thoracic and lumbar major fractures, 214 compression fractures, and 34 transverse process fractures from Los Angeles County-University of Southern California Medical Center and Rancho Los Amigos Hospital were reviewed. Epidemiology, fracture type, and early results of treatment in terms of musculoskeletal and neurologic stability were studied. Flexion-rotation fractures of the cervical, thoracic, and lumbar spine showed significant loss of reduction when not treated with operative internal fixation. Operative intervention did not influence the neurologic outcome. Laminectomy resulted in progressive deformity and a significantly increased incidence of second operations. Epidemiology indicated changing patterns of fracture.

Adult↗