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Biomedical subjects

L Crevasse

Publications and source records attributed to L Crevasse.

17 recordsLinked to original sources
PubMed1988

Quinidine: an update on therapeutics, pharmacokinetics and serum concentration monitoring.

After 70 years of regular use, quinidine remains one of the most useful drugs in the management of both supraventricular and ventricular arrhythmias. Quinidine sulfate, from conventional dosage forms, is absorbed rapidly and reaches peak levels in 1 hour. Sustained-release quinidine sulfate and gluconate are absorbed more slowly and, thus, may provide a more satisfactory response with less fluctuation in the peak and trough at quinidine concentrations. The half-life and absorption characteristics of sustained-release quinidine suggest that an 8- to 12-hour dosage regimen will produce smooth, sustained quinidine levels. Whereas quinidine and digitalis have been used concomitantly for years, dramatic elevations in blood digoxin levels have been observed. When quinidine is added to the regimen of a patient taking digitalis, these increased digoxin levels may be responsible for some of the adverse effects previously attributed to quinidine administration and can be reduced by adjustment of the digoxin dosage. Drug monitoring of serum quinidine concentrations as well as peak levels is essential to assess patient compliance and to determine that therapeutic levels are maintained. This is especially important because of the drug's relatively narrow therapeutic index and the changes in clearance that can result from drug interactions and renal and hepatic disturbances. A personal computer program is available to carry out pharmacokinetic calculations and assist in determining appropriate doses for individual patients.

Arrhythmias, Cardiac↗
PubMed1988

Mandatory continuing medical education in risk management training: the University of Florida's experience.

The University of Florida has been able to provide the physicians of Florida with a continuing medical education opportunity to meet their immediate needs. It offers quality education at a modest cost to the individual with considerable savings in time and cost to the individual physician. By using self-study tapes, we have developed a method of teaching physicians that provides positive reinforcement while presenting an overview of the malpractice crisis and detailing its causes. We believe we have made a significant contribution toward improving risk management techniques for the Florida physician.

Education, Medical, Continuing↗
PubMed1987

Clinical usefulness of computerized ECG systems.

Computer ECG systems provide a valuable function for ECG analysis, storage, retrieval, and serial comparison. The current systems can provide quality control of technician performance, acquisition equipment, and physician overreading. Its overall acceptability and clinical usefulness is documented in a clinical practice setting with a 90.4% computer-physician agreement in more than 20,000 ECGs. Computerized ECG systems have demonstrated their clinical usefulness in patient care.

Computers↗
PubMed1983

The influence of editing on the performance of a computer program for serial comparison of electrocardiograms.

In this study, three tests of computer ECG analysis function were conducted: 1) interpretation of serial tracings using the single record analysis program, i.e. without serial comparisons; 2) interpretation of the same tracings using a computer-comparison program; and 3) interpretation of these tracings using not only a computer-comparison program but also an editing program which allows amending of each serial record and insertion of any corrections into the computer data base before the next comparison. There was an over-all reduction of 84% in the number of statement changes needed to produce a correct final report by using the combined comparison and editing program. When this combined program was used, 81% of all computer interpretations required no alteration, --a considerable saving of time in analyzing serial electrocardiographic tracings. Serial comparison was required in in 27--45% of all ECG's taken in four medical centers.

Arrhythmias, Cardiac↗
PubMed1976

Systems analysis of computerized EKG processing center.

A functional description of a computerized system for analysis of electrocardiograms (EKGs) is presented. Although it is recognized that the diagnostic accuracy of the program is the critical parameter in determining system acceptance, other system features such as quality control, turn around time and cost are shown to be of high importance. A digital simulation of alternative configurations for on-line data acquisition is presented. The simulation predicts the system throughout and wait times in different phases of a telephone EKG transmission for combinations of interfaces, telephone lines and acquisition procedures. These results should be helpful in selecting the appropriate configuration for each special situation.

Computers↗
PubMed1974

Echocardiography.

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Cardiomyopathies↗