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Biomedical subjects

L Crampette

Publications and source records attributed to L Crampette.

48 records · Page 3Linked to original sources

[Cervical paraganglioma. Results apropos of a series of 33 patients].

During the period 1971-1993, 33 patients were treated for cervical chemodectomas, 41 tumors were diagnosed. Seven patients had multicentric tumors. All patients expect one with bilateral carotid tumor were treated surgically. A carotid resection was performed in 4 patients. Six patients were given radiation therapy: five patient after surgery and one treated by irradiation alone. During the follow-up period one patient died of bone metastasis 6 years after a partial surgery and radiation therapy, and one had local recurrence treated with irradiation. The surgical management is the major treatment of these tumors, it revealed no postoperative cerebrovascular accident and limited complications secondary to unavoidable nerves sacrifice. Radiation therapy is performed only on particular cases: surgery contra-indications and nonradical resection.

Adult↗

[Subtotal laryngectomy with cricohyoidopexy. Carcinologic results and early functional follow-up. Apropos of 49 cases].

Forty-three patients underwent a subtotal laryngectomy with cricohyoidopexy and neck dissection. The 5 years overall survival rate was 67%, the actuarial survival rate was 75%. The 5-year actuarial local control and nodal control rate were namely 89% and 90%. Pronostic factors for survival were tumor size (5-year actuarial survival rate for T2a, T2b and T3 were namely 89%, 72%, 48%) and node involvement (5 years actuarial survival rate was 85% if N-, and 46% if N+). The median duration was 22 days for decanulation, 30 days for removing the feeding tube. The median hospital discharge day was 38. Total laryngectomy was performed in one case (2.3%) for persistent aspiration. Post operative mortality was 0%. The most common complication was aspiration pneumoniae (11.6% of the cases).

Adult↗

[Calibration of laryngotracheal stenoses using a Montgomery tube: indications and results].

Montgomery T-tube is a stent which have been used to calibrate 54 patients having a laryngotracheal stenosis. Indications, insertion techniques, and care of tracheal T-tube are exposed. More than fifty percent of the patients (29 cases) were treated only with the T-tube, the mean duration of treatment was 13 months, and the mean number of tube changing was 2.3. Few complications were observed (recurrent lung infections in 11.1% of cases, swallowing troubles with aspiration in 3.7% of cases). No fatal complication was observed. In our experience, Montgomery T-tube is a valuable tool to treat laryngotracheal stenosis.

Adolescent↗

Surgical alternatives to uvulopalatopharyngoplasty in sleep apnea syndrome.

Uvulopalatopharyngoplasty (UPPP) is the surgery most often performed for sleep apnea syndrome (SAS). However, good results with UPPP, demonstrated by polysomnography, have been reported in only 50% of cases. Failure of UPPP may be caused by: 1) bad management of the SAS, which is better treated in some patients with nasal CPAP than with surgery; and 2) an airway obstruction located not only at the palatopharynx (PP) level. Other surgical procedures to enlarge other sites of obstruction are described. Retro-tongue-base-pharynx (RTBP) surgery is emphasized, including mandibular advancement, hyoid bone suspension, and tongue base reduction. Maxillomandibular advancement is the most efficient technique but also the most complicated.

Airway Obstruction↗

[Obstructive dyspnea of oropharyngeal origin].

Obstructive dyspnoea of oropharyngeal origin is a recently recognized entity with numerous clinical forms depending on age, severity and symptoms. The authors insist on the two facets of this pathology that are most frequently seen and therefore of special interest to practitioners: the oropharyngeal obstructive syndrome due to enlarged tonsils in children, and the pharyngeal obstruction responsible for snoring and for the sleep apnoea syndrome in adults. In children, tonsillectomy is necessary to avoid complications which are sometimes severe. The various clinical features of snoring and sleep apnoea syndrome in adults, as well as their exploration and treatment, are described.

Adult↗

[Snoring and sleep apnea syndrome in the elderly].

After shorts general considerations about physiologic and epidemiologic features relative to sleep, snoring and apneas in elderly, authors bring analysis of 30 snorers over sixty years. They all had a sleep recording, a ENT examination, and a pharyngeal C.T. scan. The main results are following: the high frequency of Sleep Apnea Syndrome (SAS) over 60 is to be carefully considered. So, Sleep recording appears necessary in the main part of this population. Cardiovascular, pneumologic and neurologic disease are very often associated, and do constitute elements of therapeutic choice. Velopharyngeal narrowing, without other level of superior airway closure, is the usual case. Therapeutic management is often difficult; there is a choice, in apneic patients, between Uvulo-Palato-Pharyngoplasty (UPP), sometimes impossible because of associated pathology, and nocturnal Continuous Positive Airway Pressure (CPAP), which employment is not always easy.

Age Factors↗

[Pharyngo-esophageal risk of surgery of the cervical spine using an anterior approach].

The authors report six cases of pharyngo-oesophageal damage associated with fractures of the cervical spine treated by osteo-synthesis via the anterior route. These complications, not previously described, may have life threatening (especially mediastinitis) and functional consequences. They discuss the relative responsibility of: the initial trauma, which should be better defined by an initial endoscopic assessment. the surgical approach, the principles of which and its dangers and preventive aspects are discussed, early or late fixation failure justifying careful surveillance of the osteosynthesis material and in certain cases its systematic removal.

Adult↗

[Allergic rhinitis].

1. ALLERGY: The prevalence of allergy is estimated from 15 to 35%, incidence is on the rise. 2. PATHOGENESIS: Allergy is initiated by a very specific IgE-dependent mechanism, but involves a late phase corresponding to non-specific inflammation. 3. SYMPTOMATIC CARE: "Modern" antihistamines and local intranasal corticosteroid therapy constitute the basis of symptomatic treatment.

Anti-Allergic Agents↗

[Nasal-paranasal sinus polyposis].

1. POLYPOSIS AND ALLERGY: Nasosinusal polyposis and allergy must be considered as two distinct conditions. 2. POLYPOSIS: Approximately 1% of the general population has nasosinusal polyposis, a condition strongly associated with asthma (about one-third of the patients with polyposis have asthma). Patients with nasosinusal should undergo a complete respiratory examination in order to search for asthma or an asthma equivalent. 3. EOSINOPHILS: Eosiophils play a crucial role in the inflammatory reaction, releasing almost all the known inflammatory mediators: cytokines, chemokines and growth factors. 4. EPITHELIAL CELL: The epithelial cell probably plays a very important role. 5. MEDICAL TREATMENT: Long-duration intranasal corticotherapy is the basis of drug treatment. Short courses of oral corticosteroids may be useful during acute episodes in inflammation. The exact effect of oral corticosterid is not clearly elucidated but it is known that non-steroidal antiinflammatory drugs (NSAID) are contraindicated in polyposis. 6. SURGICAL TREATMENT: Surgery is reserved for medical failures or for patients with a contraindication for drug therapy. Endonasal ethmoidectomy is the basis treatment. 7. PERSPECTIVES: Better understanding of the underlying pathophysiology and the probable genetic component will determine future treatments. Perspectives include antiinflammatory drugs currently reserved for other conditions (antileucotriene, antiTNFa, IL-18) and elaboration of new antiinflammatory drugs.

Humans↗

[Cervical paragangliomas. Results apropos of a series of 33 patients].

During the period 1971-1993, 33 patients were treated for cervical chemodectomas, 41 tumors were diagnosed. Seven patients had multicentric tumors. All patients expect one with bilateral carotid tumor were treated surgically. A carotid resection was performed in 4 patients. Six patients were given radiation therapy: five patient after surgery and one treated by irradiation alone. During the follow-up period one patient died of bone metastasis 6 year after a partial surgery and radiation therapy, and one had local recurrence treated with irradiation. The surgical management is the major treatment of these tumors, it revealed no postoperative cerebrovascular accident and limited complications secondary to unavoidable nerves sacrifice. Radiation therapy is performed only on particular cases: surgery contra-indications and nonradical resection.

Adult↗