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Biomedical subjects

L Cohen

Publications and source records attributed to L Cohen.

At least 415 records · Page 23Linked to original sources
PubMed1985

Treatment of vaginal candidosis using clotrimazole vaginal cream: single dose versus 3-day therapy.

The effect of using a single dose of 10% clotrimazole cream was compared with that of using a twice-daily application of 2% clotrimazole cream for 3 days in 111 women with mycologically proven vaginal candidosis. The results, analyzed for 55 patients in each group, showed that 1 week after starting treatment, negative cultures were recorded for 91% of the patients who received single-dose therapy and 96% of patients treated with the 3-day regimen. Five weeks after treatment started, the figures were 84% and 81%, respectively, showing that both regimens were equally effective. No adverse events were recorded for either preparation.

Administration, Topical↗
PubMed1985

[What is the use of the radioimmunoassay of prostatic acid phosphatase?].

Radioimmunoassay (RIA) of prostatic acid phosphatases (PAP) using the Gammadab (R) PAP pack supplied by Clinical Assays in an effective method for determining extension of prostatic cancer. In patients with lymph node or metastatic invasion serum assay values are almost always elevated (sensitivity = 94%), especially with well differentiated cancer. Elevated levels of this variable are practically pathognomonic of external extension (specificity = 94%). This is of importance in therapy since the degree of invasion determines the choice between palliative and curative treatment. Strategy leading to this therapeutic choice can be greatly simplified and thus modified by RIA of PAP.

Acid Phosphatase↗
PubMed1985

Behçet's disease: clinical and immunological response to immunosuppressive therapy. A case report.

A patient with Behçet's disease had recurrent bilateral uveitis with retinal exudates and visual deterioration while under intermittent corticosteroid treatment. His peripheral blood lymphocytes showed the following abnormalities: low percentage of T cells; low T cell suppressor activity; high spontaneous B cell proliferation; and high response to phytohemagglutinin. Prostaglandin-producing adherent cells were found to have suppressive activity. Chlorambucil induced a clinical and immunological remission.

Adult↗
PubMed1985

Bone magnesium in chronic obstructive pulmonary disease with hypercapnia.

Serum, bone and urinary magnesium as well as bone mineral crystal size and perfection were determined in 10 chronic hypercapnic patients with chronic obstructive pulmonary disease. Decreased serum magnesium levels were found. Urinary magnesium excretion decreased while bone magnesium increased. Bone mineral crystal size and perfection decreased.

Aged↗
PubMed1985

Extracellular distribution of radiolabel obscures specific binding of diethylstilbestrol in mouse skeletal muscle.

The extracellular distribution of 3H-diethylstilbestrol (3H-DES) in mouse skeletal muscle was assessed following intraperitoneal injection. Total muscle extracellular space was measured with 14C-inulin, and the vascular space with 125I-albumin. A significant difference in the distribution of native 3H-DES and its metabolites in muscle and blood was found. This could only be explained if these compounds distributed with the albumin space and not the inulin space.

Albumins↗
PubMed1985

Magnesium and liver cirrhosis: a hypothesis.

Low serum, cerebrospinal fluid, erythrocyte, muscle and bone Mg concentrations have been found in liver cirrhosis, indicating a Mg deficiency. Decreased intake, fat malabsorption, renal tubular acidosis and increased serum levels of aldosterone, growth hormone and glucagon could be the causative factors.

Humans↗
PubMed1985

Early radiation-induced proctosigmoiditis responds to magnesium therapy.

A group of 10 patients with cervical carcinoma with early radiation-induced proctosigmoiditis and low serum Mg levels was treated with low residue diet and antidiarrheals. The diarrhea cleared within a period of 2-6 weeks. A second group of 10 patients with hypomagnesemia was treated with intravenous infusion of Mg sulfate for 3 consecutive days. The diarrhea disappeared by the end of treatment, paralleling normalization of serum Mg levels.

Colitis↗
PubMed1985

Lymphocyte and bone magnesium in alcohol-associated osteoporosis.

Serum, lymphocyte and bone magnesium concentrations were determined in 5 alcoholic patients in order to assess their total body magnesium status. Decreased values confirmed the existence of magnesium deficiency in chronic alcoholism. Spinal osteoporosis on X-rays, together with magnesium deficiency and decreased bone magnesium concentration in alcohol-associated osteoporosis match similar findings in involutional osteoporosis.

Alcoholism↗
PubMed1985

Pheochromocytoma--a rare cause of hypermagnesemia.

A case of hypermagnesemia associated with pheochromocytoma is described. A further increase in serum Mg was observed with initiation of beta-blocking therapy. Unilateral adrenalectomy normalized serum Mg levels.

Adrenal Gland Neoplasms↗
PubMed1985

The myth of long-term thiazide-induced magnesium deficiency.

A group of 8 patients with essential hypertension and 12 patients with recurrent renal calcium stones were treated with 50 mg hydrochlorothiazide daily for a period of 3-10 years. Serum, erythrocyte, lymphocyte, skeletal muscle, bone and urine Mg were found to be within the normal range. In the intravenous Mg load test, all patients retained a normal percentage of the loading dose of Mg. Long-term thiazide therapy does not appear to lead to Mg depletion.

Bone and Bones↗
PubMed1984

Cantharidin poisoning with neurological complications.

Two cases of cantharidin poisoning are described in which the patients developed the well-known complications of acute renal failure and pseudopolycythaemia. In addition both developed a Guillain-Barré type of flaccid paralysis but spontaneous reversal occurred. Cantharidin poisoning may be responsible for some of the unexplained neurological presentations in Black South Africans.

Adult↗
PubMed1984

Response of epidermoid and non-epidermoid cancers of the head and neck to fast neutron irradiation: the Fermilab experience.

One hundred and six patients with locally advanced cancers of the head and neck were treated with neutrons at the Fermilab Neutron Therapy Facility. Of these, 44 patients were previously untreated, 33 were recurrent following attempted surgery and 29 patients had previously received a full course of radiation therapy with conventional radiation. Results were analyzed to study the influence of stage, previous management, site of origin and tumor histology on local control of the disease. The most significant factor determining the outcome in this series of patients is the histological type. For epidermoid carcinoma, long term local control was achieved in 17/35 patients (49%) in the previously unirradiated group. With non-epidermoid tumors (adenocarcinoma, cylindroma, muco-epidermoid carcinoma), the local control rate was 28/39 (72%). Disease-free survival analysis also shows a survival advantage in non-epidermoid lesions treated with neutrons. It is concluded that neutron beam therapy may probably be the treatment of choice for non-resectable or recurrent non-epidermoid cancers of the head and neck and requires a clinical trial to establish this observation.

Adenocarcinoma↗