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Biomedical subjects

L Cerezo

Publications and source records attributed to L Cerezo.

At least 37 records · Page 2Linked to original sources
PubMed1986

Acid phosphatase positivity in childhood acute lymphocytic leukemia.

The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

Acid Phosphatase↗
PubMed1986

Ovarian cavernous hemangioma.

Vascular tumors of the female genital tract are rare, especially those of the ovary. Most cases are small lesions that are discovered incidentally. We describe a 68-year-old woman with a benign hemangioma that presented clinically as a very large ovarian mass.

Aged↗
PubMed1985

Institutional performance in application of the FAB classification of acute leukemia. The Southwest Oncology Group experience.

Institutional performance in application of the French-American-British (FAB) classification of acute leukemia in The Southwest Oncology Group is presented, demonstrating a disparity between institutional and expert performance. A significant improvement is shown with an educational effort coupled with experience in use of the classification, and the importance of cytochemistry in the use of the classification is illustrated. A simplification of the classification, merging M1, M2, and M4 as M7, is proposed. This simplification improves institutional performance in use of the classification, while preserving distinctions that appear clinically important.

Acute Disease↗
PubMed1985

Reproducibility of the French-American-British classification of acute leukemia: the Southwest Oncology Group Experience.

After initial French-American-British (FAB) diagnosis by a multiinstitutional Southwest Oncology Group panel, slides of acute leukemia cases were recirculated to panel members for second review. The reproducibility of the FAB classification is analyzed. The classification is reproducible in the 70% range in panel reviewer hands and allows remarkable reproducibility in the morphologic and cytochemical distinction of acute lymphoid leukemia (ALL) from acute myeloid leukemia (AML). The limitations of a morphologic and cytochemical classification of acute leukemia are discussed. A simplification of the FAB system, merging M1, M2, and M4 as M7, is proposed; this simplification improves the system's reproducibility.

Acute Disease↗
PubMed1985

Adenosquamous carcinoma of the colon.

Two cases of primary adenosquamous carcinomas of the sigmoid colon and rectum are presented. Clinical features and pathologic findings of both primary and metastatic lesions are reported (including immunohistochemistry and electron microscopy). We emphasize that the presence of a metastatic squamous tumor in a patient with an unknown primary does not exclude the possibility of colonic carcinoma. Comparison with other reports in the American medical literature indicates that these are very aggressive tumors that may have a worse prognosis than the more common form of colonic adenocarcinoma. Furthermore, the squamous component, in particular, may have a greater potential for metastasizing and can do so as an undifferentiated-appearing carcinoma. In view of this, the authors suggest that very poorly differentiated areas within colonic adenocarcinomas should be very carefully evaluated by means of immunoperoxidase stains and/or electron microscopy in an attempt to identify squamous features.

Adenocarcinoma↗
PubMed1985

Electron microscopic diagnosis of cerebral toxoplasmosis. Case report.

Rapid and specific diagnosis of infections involving patients with acquired immunodeficiency syndrome (AIDS) is imperative. Toxoplasmosis is one of the most frequent causes of central nervous system disease in these patients. The authors present a case of cerebral toxoplasmosis in an AIDS patient, diagnosed by electron microscopy of brain biopsy tissue using rapid techniques.

Acquired Immunodeficiency Syndrome↗
PubMed1984

The prevalence of hand-mirror cells in acute myeloblastic and lymphoblastic leukemia.

To evaluate the prevalence and significance of hand-mirror cells (HMC) in acute leukemia, 214 cases were studied retrospectively. They were classified by FAB and included 102 pediatric and 112 adult cases. Greater than 10% HMC were found in 6.5%. No overall difference was noted with age group, though HMC were more common in lymphoblastic cases (10% versus 3%). However, the greatest number of HMC were found in four adult cases, three of which were myeloblastic. Of the lymphoblastic cases with greater than 10% HMC, T and B studies were done in three that were typed as one T cell and two non-T cell (L1, CALL+; L3, sIg+). Forty-eight other cases with less than 10% HMC included 13 T cell and 35 non-T cell. The authors conclude that HMC may not correlate with morphologic or immune cell type and they do not appear to be a specific marker for a type of lymphoblastic and/or T-cell leukemia.

Adolescent↗
PubMed1983

B-cell multilobated lymphoma.

A 59-year-old man was hospitalized for evaluation of cervical lymph node enlargement, and a diagnosis of a diffuse histiocytic lymphoma with B-cell markers was made. The unusual multilobated nature of the lymphoma cells is the subject of this study. The light and electron microscopic features are described and compared with those previously reported T-cell lymphomas which appear to have similar morphologic features. The importance of performing immunologic marker assays to determine T-cell or B-cell type and the limited predictive value of morphologic features in this regard are emphasized.

B-Lymphocytes↗
PubMed1981

Coronary arterial stenosis and subclavian steal in Takayasu's arteritis.

This report describes a young boy with previous myocardial infarction and hypertension. Demonstration of coronary arterial ostial stenosis and a variant of subclavian steal was documented by selective arteriography. Surgical resolution of the most important stenosis is descending aorta, permitted effective control of hypertension. It is considered that one could reach this arteritis through different etiologies, tuberculosis having a preponderant place, and that it is important in all cases to carry out coronary arteriography.

Aorta↗
PubMed1981

Cerebellar hemangioblastoma with clear nuclei. Case report and ultrastructural study.

A case of cystic cerebellar hemangioblastoma with previously unreported light and electron microscopic features is reported. Deposits of intranuclear, osmiophilic, lipid-like material produced unusual stromal cells, with distended clear nuclei similar to empty cysts at the light-microscopic level. This description expands the morphologic spectrum of this rare tumor.

Adult↗
PubMed1980

Bone marrow necrosis.

Extensive bone marrow necrosis is an unusual histologic finding most commonly identified after autopsy. We describe a patient with poorly differentiated lymphocytic lymphoma who manifested pancytopenia and marrow necrosis. Bone marrow scanning with 99mTc-sulfur-minicolloid provided a noninvasive means to assess the extent of marrow damage. Our patient's condition improved clinically following cytotoxic chemotherapy demonstrating that marrow necrosis may be associated with a treatable disease.

Adult↗