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Biomedical subjects

L Cebon

Publications and source records attributed to L Cebon.

9 recordsLinked to original sources
PubMed1984

Solitary silent venous papillary loops and ocular hypertension.

A series of 24 eyes in 23 patients is described showing solitary silent venous papillary loops. These loops are usually associated with a considerable degree of ocular hypertension, presenting when this hypertension is being investigated. They are silent, usually with no previous ocular history, single with a large diameter, affecting veins at the optic disc and not extending into the vitreous. The optic disc is cupped, but usually not more than 0.6 disc diameter, there is good central vision and either a full visual field or only early field loss. Fluorescein angiography shows the loops to be competent with no evidence of any other retinal vascular abnormality. Rarely loss of central vision may occur due to progression to advanced glaucoma. The condition is distinct from prepapillary vascular arterial papillary loops, neovascularization at the optic disc and optociliary shunt vessels. It is also distinct from the venous collateral vessels which develop at the optic disc after acute central or branch retinal vein occlusion. These collaterals are usually multiple, the accompanying ocular hypertension is of lesser degree, cupping of the disc and field loss are usually much more advanced and, while visual acuity may be normal, it is often grossly reduced. On fluorescein angiography all these cases of venous collaterals after retinal vein occlusion showed evidence of other retinal vascular dysfunction. Solitary silent venous papillary loops appear to develop from venules on the optic disc as a bypass to a low grade venous occlusion which is seldom clinically manifest. They form a distinct entity with a good prognosis if the accompanying ocular hypertension is carefully controlled.

Aged↗
PubMed1983

Drop attack in glaucoma. The Melbourne experience with topical miotics, adrenergic and neuronal blocking drops.

We have considered the effectiveness of miotics (pilocarpine 2% and ecothiopate iodide (Phospholine Iodide) 0.125 or 0.25%), adrenaline (Eppy/N 1%) or adrenaline precursors (dipivalyl epinephrine or dipivefrin hydrochloride (Propine) 0.1%) and neuronal blockers (timolol maleate (Timoptol) 0.5%) in 165 patients in the clinical situation. All drops were effective in lowering intraocular pressure with an average fall of 6.6 mmHg for timolol (160 eyes), 8.21 mmHg for pilocarpine (79 eyes), 5.77 mmHg for dipivalyl epinephrine (57 eyes), 7.23 mmHg for adrenaline (17 eyes) and 10.5 mmHg for ecothiopate iodide (16 eyes). In chronic simple open-angle glaucoma, ocular hypertension and pseudoexfoliative glaucoma, pilocarpine and timolol were almost equally effective while dipivalyl epinephrine and adrenaline were also effective, but more as additive therapy, though dipivalyl epinephrine may be useful on its own in ocular hypertension. In low-tension glaucoma timolol and dipivalyl epinephrine together seemed best, while in secondary glaucomas all were effective at times, but ecothiopate iodide was best in aphakic glaucoma and fluorometholone (FML Liquifilm) 0.1% was important in inflammatory glaucoma. Side effects were frequent with dipivalyl epinephrine and timolol, with respiratory disease a strong contraindication to timolol.

Echothiophate Iodide↗
PubMed1983

Timoptol--three years on. A study of timolol maleate drops over a longer period.

A group of 130 patients with chronic glaucoma has been followed from one to more than three years on timolol maleate drops; this confirms that these drops remain effective in long-term therapy through added therapy is usually needed. Of 54 patients originally controlled by timolol alone or in combination, only four were not controlled more than three years later, though some needed further additional therapy. Of 35 patients followed for two to three years, only six could not be controlled by timolol alone or in combination; and of 41 followed for one to two years, 18 were controlled on timolol alone while 23 needed additional therapy. Attention is drawn to side effects including a mild keratopathy and in particular the occurrence of bronchospasm or other severe respiratory disease in 10 patients, not all of whom had a previous history of respiratory disease. Great care should be exercised with timolol in the presence of present or past respiratory disease as the complication is not generally recognised and it falls to the ophthalmologist to act to stop the drop.

Drug Therapy, Combination↗
PubMed1983

Experience with dipivalyl epinephrine. Its effectiveness, alone or in combination, and its side effects.

Dipivalyl epinephrine was as effective as adrenaline as an eyedrop for glaucoma. It was responsible for fewer side effects, through side effects did occur. It had an additive effect when used with timolol maleate and, in 12 of 14 patients on long-term medication with both drugs, a rise of pressure of 3 mmHg or more occurred when dipivalyl epinephrine was stopped. As sole therapy dipivalyl epinephrine was effective in chronic simple open-angle glaucoma, ocular hypertension and pseudoexfoliative glaucoma, and may be useful on its own in the latter two conditions. In low-tension glaucoma it seemed the best therapy when combined with timolol. Headache and ocular pain were uncommon but prominent side effects.

Drug Therapy, Combination↗
PubMed1983

Laser trabeculotomy or trabeculoplasty. Early experience with a new non-invasive surgical technique for glaucoma.

A series of 38 laser trabeculoplasty operations in 32 eyes of 29 patients is described. An average fall of 5.32 mmHg intraocular pressure was obtained; if secondary glaucomas were excluded the average fall was 7.39 mmHg. If a fall of 10 mmHg or more is considered a good result then eight eyes obtained a good result, five of these eyes having pseudoexfoliative glaucoma. A fall of 3-9 mmHg was considered a moderate result and 12 eyes obtained this, 11 of them having chronic simple open-angle glaucoma, the other being the only other case of pseudoexfoliative glaucoma in the series. Five eyes with chronic simple open-angle glaucoma and seven eyes with secondary glaucoma all obtained no significant fall. It is stressed that in chronic simple open-angle glaucoma there was often only a small fall or no fall at all, so that it seems unwise to temporize if there is a high uncontrolled pressure in this condition. Great care is also needed in advanced chronic simple open-angle glaucoma because of the occasional occurrence of a high rise of pressure soon after operation. The procedure works well in pseudoexfoliative glaucoma.

Glaucoma↗