Ruptured Baker cyst diagnosed by scintiarthrography.
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Bursitis↗
Biomedical subjects
L Carrier
Publications and source records attributed to L Carrier.
Cystic hypernephroma mimicking an hepatic mass.
A renal mass was correctly identified with Tc-99m sulfur colloid liver-spleen scan and Tc-99m glucoheptonate scintigraphy while CT scan was misinterpreted as showing a hepatic lesion.
Aged↗
[Clinical evaluation of leukocytes labeled with indium 111-oxine in the diagnosis of abdominal abscesses and echographic correlations].
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Abdomen↗
Regulation of myosin heavy chain and actin isogenes expression during cardiac growth.
The cardiac ventricular myosin heavy chain phenotype is developmentally and hormonally regulated, but less is known concerning the actin phenotype. In this study, the levels of accumulation of alpha-skeletal and alpha-cardiac actin mRNAs were investigated in rat and human ventricles by primer extension assays. In rat, the two iso-mRNAs are present in approximately equal amounts from birth until 15 days of age and the cardiac form is predominant in adult and senescent hearts. Hypothyroid development has no effect, at least during the first two weeks of age. In man, the two isoactins are co-expressed to similar ratios in one control heart and in one failing heart. It therefore appears that myosin heavy chain and actin multigene families are both expressed in a species specific fashion but are independently regulated within a species. Preliminary results from nuclear run-on assays are presented that indicate differences in the level of transcription of the alpha-actin and beta-myosin heavy chain isogenes in the rat heart.
Actins↗
Multidirectional analysis of maximal voluntary contractions of the thumb.
A multidirectional dynamometer was used to investigate the maximal static force (MSF) exerted at the proximal phalanx of the dominant and nondominant thumbs of 12 normal women subjects. These MSFs were measured in two sessions within a two-week interval. Eight directions covering 360 degrees, at increments of 45 degrees within the transverse plane of the longitudinal axis of the thumb, were examined. A three-way analysis of variance (ANOVA) with repeated measures (factors: direction, session, handedness) was performed. No significant interaction was found between the main factors. The ANOVA showed that MSFs vary according to the direction of effort. No significant difference, however, was observed between the dominant and nondominant thumbs or between the MSFs obtained in the two sessions. Post-hoc analysis revealed that MSFs exerted in directions containing an abduction component were significantly lower than MSFs exerted in the other directions. It is concluded that directional strength of the thumb is maximized for functional grasping activities and reflects the anatomic distribution of muscles acting at the thumb.
Adult↗
Cardiac myosin binding protein C gene is specifically expressed in heart during murine and human development.
Cardiac myosin binding protein C (MyBP-C) is a substantial component of the sarcomere, with both structural and regulatory roles. The gene encoding cardiac MyBP-C in humans is located on chromosome 11p11.2, and mutations that are most predicted to produce truncated proteins have been identified in this gene in unrelated families with familial hypertrophic cardiomyopathy (FHC). To understand better the pathophysiology of FHC and with a view to the development of animal models for this disease, we have investigated by in situ hybridization the pattern of expression of the cardiac MyBP-C gene during human and mouse development using species-specific oligonucleotide probes. From 4 weeks of human development, a strong labeling of cardiac MyBP-C mRNAs was unambiguously detected in all heart compartments, and no signal could be visualized in somites. In murine embryos, from embryonic day 9.5 until birth, a strong signal was detected exclusively in the heart. Our results showed that during both human and murine development, in contrast to chicken development, the cardiac MyBP-C gene is abundantly and specifically expressed in the heart.
Animals↗
Depression in Alzheimer's disease: receiver operating characteristic analysis of the Cornell Scale for Depression in Dementia and the Hamilton Depression Scale.
This study compares the performance of the Cornell Scale for Depression in Dementia (CSDD) and the Hamilton Depression Scale (HDS) in detecting Research Diagnostic Criteria (RDC) major depression in subjects with mild-to-moderate Alzheimer's disease (AD). Thirty-four subjects with this diagnosis and their caregivers were interviewed. The senior author conducted a diagnostic interview to determine RDC diagnosis. An investigator, blind to diagnosis, obtained demographic information and administered the Mini Mental State Examination, Global Deterioration Scale, CSDD and HDS. For each depression scale, the correlation with the RDC diagnosis of major depression was calculated, as were the sensitivity and specificity at various cutoff scores. Nonparametric receiver operating characteristic analysis was used to compare the performance of the two scales. The area under the receiver operating characteristic curve was .91 for the CSDD and .87 for the HDS. This differed from chance to a highly significant degree for both the CSDD and the HDS but the difference between the two scales was not statistically significant. Although the precision of the present study is limited by the small sample size, a cutpoint of 7 provided reasonable performance for both the CSDD and the HDS, yielding a sensitivity of .90 for both scales and a specificity of .75 for the CSDD and 0.63 for the HDS. Although the CSDD and the HDS are rating scales rather than diagnostic instruments, receiver operating characteristic analysis indicates that both demonstrate statistically significant discriminating ability for RDC major depression in mild to moderate, probable AD.(ABSTRACT TRUNCATED AT 250 WORDS)
Aged↗
Prevalence of depression in Alzheimer's disease and validity of Research Diagnostic Criteria.
This study was undertaken to estimate the point-prevalence of Research Diagnostic Criteria (RDC) depressive syndromes in Alzheimer's disease (AD) and to evaluate the validity of existing and potential alternative diagnostic criteria for major depression in the presence of probable AD. Twenty-six subjects with probable AD of mild to moderate severity and their caregivers were interviewed to estimate the prevalence of RDC depressive syndromes. For the evaluation of the validity of RDC for major depression, an additional 8 probable-AD subjects with suspected depression were added to the sample. Sensitivity, specificity, and correlation with diagnosis of RDC major depression were calculated for each diagnostic criterion, and existing major depressive criteria were compared to potential alternative criteria currently used for RDC minor depression. Of the subjects in our prevalence sample, 15.4% were found to have major depression; 23.1%, minor depression; and 11.5%, intermittent depression. In our validation sample, two criteria for major depression, self-reproach/guilt and thinking/concentration difficulty, were weakly associated with the final diagnosis of major depression because of poor sensitivity or specificity. In contrast, three possible alternative criteria were significantly associated with the diagnosis of major depression and showed high sensitivity and specificity. These included nonverbal manifestations of depression, irritability/complaining, and demandingness/dependency. We conclude that RDC depressive syndromes are common in probable AD of mild to moderate severity. In the presence of AD, the validity of some existing major depressive criteria may be limited in comparison to several potential alternative criteria because of relatively poor sensitivity and/or specificity.
Adult↗
Asymptomatic heterotopic thyroid tumour in the right ventricular infundibulum.
An asymptomatic thyroid cardiac tumour was discovered in the right ventricular infundibulum of a 63-year-old female investigated for angina. The results of the investigation are presented: coronary angiography, echocardiography, magnetic resonance imaging, resting radioactive 201-thallium scintigraphy, dipyridamole-thallium scintigraphy, nuclear isotopic ventriculography. The tumour was successfully removed at surgery for coronary bypass. Anatomopathological description is also included.
Choristoma↗