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Biomedical subjects

L Carlisle

Publications and source records attributed to L Carlisle.

21 records · Page 2Linked to original sources

Chemical labyrinthectomy with NaCl. Menière's disease treatment with deposition of NaCl in the vestibule.

Thirteen individuals with unilateral Menière's disease were chosen for experimental chemical labyrinthectomy. All subjects suffered from frequent attacks of disabling vertigo and had mean pure-tone thresholds greater than 50 dB in the affected ear. The surgical procedure was similar to stapedectomy; after removal of the stapes, several crystals of NaCl were placed in the vestibule which was then covered with a vein graft. Postoperative recovery was rapid, allowing patients to be discharged 4-6 days after surgery. Of the 13 subjects, all reported complete relief from vertigo. Tinnitus was cured in 7 subjects, greatly improved in 4 and unchanged in 2. Most patients complaining of aural fullness preoperatively reported relief from this symptom following surgery. To date (up to 4 years post-surgery) none of the subjects has shown any significant alteration in audiologic or vestibular function in the contralateral ear. The ease and safety of this procedure make it an attractive method when cochleovestibular deafferentation is indicated.

Adult↗

Development of cochlear-wall implants for electrical stimulation of the auditory nerve.

The aim of these experiments was to investigate the use of titanium implants for anchorage of stimulating electrodes or other clinical or experimental devices in the bony wall of the cochlea. Twenty-six cylindrical titanium fixtures, 0.6 mm in diameter, were inserted into holes drilled in the otic capsule in 8 ears in 5 nonhuman primates and then examined for stability after periods of 2 months to 2 years. Following sacrifice, the bone-metal interfaces were examined microscopically. Fourteen of the implants were firmly fixed in the bone, 6 were loosely fixed and 6 came out. Poor fixation was associated with infection in the middle ear. In uninfected ears, 90% of the implants were stable. The implants were not osseointegrated in the classic sense, but in stable implants, direct bone contact covering 5 to 60% of the titanium oxide surface of the implant shaft was observed.

Animals↗

Appropriateness of acute medical admissions and length of stay.

OBJECTIVE: To use the Appropriateness Evaluation Protocol (AEP) to assess the extent of inappropriate utilisation of hospital beds by acute medical patients. To determine whether clinicians viewed the AEP decisions as valid. DESIGN: Retrospective review of the medical records of a 10% random sample of 8,210 patients admitted as medical emergencies. An objective independent review instrument (AEP) was used to assess the medical necessity for hospitalisation at admission and on each subsequent day. To test the validity of the screening instrument, a subsample of the reviewed records was further assessed by a panel of physicians. SETTING: A district general hospital in the West Midlands region of England. SUBJECTS: Eight hundred and twenty-one adult patients admitted to general medicine during one calendar year. MAIN OUTCOME MEASURES: Proportions of admissions and days of care for which inpatient medical care was judged appropriate. Reasons for inappropriate utilisation and potential bed-days that could be saved by the development and use of alternative services were also considered. Validity of the AEP was tested by assessing agreement between the majority decision of an expert panel and the criterion-based AEP decision. RESULTS: AEP identified 51/821 (6%) admissions and 2,195/4,885 (45%) days of care as inappropriate. Over half the patients had a hospital stay in which at least half the days were judged inappropriate. The commonest reason for inappropriate days was remaining in hospital after the medical purpose for admission had been accomplished. This accounted for 38% of inappropriate days reviewed. In validity testing there was a high level of agreement between the physicians and the AEP, with kappa values greater than 0.80 for admissions and days of care. CONCLUSIONS: The AEP is a valid and useful instrument for assessing the utilisation of acute medical beds in a NHS hospital. In this study acute medical admissions were largely appropriate at the time of admission but a substantial proportion of subsequent days of care was considered inappropriate by AEP criteria. Most inappropriate utilisation was due to organisational issues within the hospital. As a result of this study, several service and policy developments were identified that should improve the efficiency of bed utilisation at the hospital.

Adolescent↗