Search PubMed⌕ Search

Biomedical subjects

L Carenza

Publications and source records attributed to L Carenza.

At least 37 records · Page 2Linked to original sources
PubMed1986

Peripheral neuropathy and ototoxicity of dichlorodiamineplatinum: instrumental evaluation. Preliminary results.

Clinical use of cis-platinum in the treatment of many human tumors is increasing. Since side effects could represent a limitation of its use, we evaluated neurotoxic effects of this compound in a group of 23 patients on antiblastic treatment for gynecological neoplasms. Evaluation was performed by clinical-neurological examination, neurophysiological data (electromyography, maximal motor conduction velocity, and sensory conduction velocity) and potentials. Seven patients reported subjective symptoms of neurological involvement. In 2 cases there was a change in the electromyographic pattern. The otolaryngological examination showed a change in the hearing threshold in 3 patients and in 1 case the fatigue test was positive. Neurotoxic effects and hearing damage was not related to the treatment schedule.

Adolescent↗
PubMed1982

Urodynamic in the diagnosis and treatment of urinary stress incontinence.

The authors examine the role of the urodynamic test on patients suffering from stress incontinence. The simultaneous recording of the flowmetry and of bladder and urethral pressures continues to be the most efficient method for the functional demonstration of urinary incontinence. According to the authors, however, it is necessary to evaluate, before the operation, the suitability of the bladder for surgical intervention to avoid any voiding disorders which might occur following surgery. The cystosphinctermanometry with simultaneous flowmetry, together with the stop test, allows for a precise analysis of the particular voiding habit of each bladder, thus permitting an evaluation of the two essential parameters for surgical treatment; bladder capacity, and the characteristics of the detrusor contractability.

Humans↗
PubMed1981

Substantial amounts of gonadotrophin-like materials in sera of normal subjects.

Ultrafiltration of human sera resulted in increased levels of human chorionic gonadotrophin (hCH), LH and FSH measured by radioimmunoassay. The effect was greatly enhanced by chromatography of serum through Sepharose-protein A (which specifically binds immunoglobulin G) followed by ultrafiltration of the unretarded fractions. Serum from a normally menstruating women was treated by ultrafiltration and the retained fraction from 200 mul serum further chromatographed on a Sephadex G-150 Superfine column. The amounts of LH and FSH measured in the eluate by radioimmunoassay were higher by three orders of magnitude than those found in the untreated serum. Comparable amounts of hCG were also found in the eluate by two specific radioimmunoassays, and a value of 45 i.u. hCG was recovered in the eluate by bioassay. Serum from another normally menstruating women was applied to DEAE-cellulose and eluted stepwise using an elution gradient. The ultrafiltrate of one eluted fraction led to separation of a low molecular weight material which was able to neutralize the biological activity of a large dose of hCG. The data support the hypothesis that substantial amounts of gonadotrophins are normally present in serum but that binding to inhibitor(s) prevents their assay in untreated sera.

Biological Assay↗
PubMed1980

Levels of HCG in subjects using the Progestasert(TM) intrauterine progesterone systems.

Twelve subjects using the intrauterine progesterone system were followed during 4 consecutive menstrual cycles for FSH, LH, hCG and progesterone levels. They were all multiparous, with documented ovulation and sexually active even during the ovulatory period. With the exception of one case which became pregnant, there was no evidence for the presence of hCG during the period of observation. This data, even if preliminary, suggest that the Progestasert(TM) exerts a contraceptive action which differs from that of other devices, whether medicated or not, and that, such action occurs at a stage early enough to prevent the formation of hCG.

Adult↗