Ventricular septal defect: clinical and hemodynamic changes in the first five years of life.
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Blood Pressure↗
Biomedical subjects
L Calder
Publications and source records attributed to L Calder.
The in vitro effects of D-penicillamine upon anti-AChR production by thymic and peripheral blood lymphocytes from patients with myasthenia gravis.
D-Penicillamine added to lymphocyte cultures from myasthenia gravis patients infrequently and inconsistently stimulated anti-AChR production. This usually occurred in the presence of pokeweed mitogen (PWM), and often only at a single concentration of D-penicillamine which varied among patients. The change was typically paralleled by an increase in total IgG production of similar magnitude, suggesting that the effect was nonspecific. D-penicillamine did not affect AChR expression in cultured thymic adherent cells. These data provide no evidence that penicillamine induces myasthenia gravis by direct stimulation of anti-AChR antibody-producing cells.
Adolescent↗
Aortic valvar atresia, interrupted aortic arch, and quadricuspid pulmonary valve: a rare combination.
Aortic atresia and interrupted aortic arch is a rare cardiac combination. Review of the literature revealed nine cases. We present two patients with this combination and the additional finding of quadricuspid pulmonary valves, one of which was severely stenotic. In the latter patient, an aortopulmonary window was present. The other had a unique blood supply to the brachiocephalic arteries and ascending aorta from systemic collateral arteries. To the best of our knowledge, the association of a quadricuspid pulmonary valve with this combination has not been previously reported.
Abnormalities, Multiple↗
The impact of women on women's health research: an interview with Dr. Ruth Wilson. Interview by Lisa Calder.
As women become more prominent players in the health sciences, it seems logical to ask the question, How are women affecting issues of health specific to women? Few authors have addressed this important query. In this article, I look at the views of a female researcher with respect to the literature about women's health research and the impact of women researchers on the information exchange between patient and physician, provider competence, and continuity of care. These factors all affect the quality of care being received by women in many different areas of health care.
Canada↗
Kawasaki disease with severe cardiac sequelae: lessons from recent New Zealand experience.
OBJECTIVES: To review recent cases of Kawasaki disease (KD) with significant cardiac sequelae in New Zealand. It is known that intravenous immunoglobulin (IVIG) reduces the risk of coronary artery aneurysm formation if given within 8-10 days of onset of KD. METHODS: Retrospective review of medical course, criteria for KD, laboratory and cardiac findings for six children identified with KD and significant coronary artery sequelae. RESULTS: There was delay in diagnosis of KD in three of the six children. Three cases were atypical by extremes of age (2 months, 10 years, 14 years). By definition all six children had significant coronary artery involvement. One patient had a thrombus detected in a coronary aneurysm 3 weeks after KD. One patient underwent coronary artery bypass grafting for unstable angina 2 years after KD. One patient developed coronary artery aneurysms after an initial 'toxic shock' type illness evolving to KD. Three patients died, one due to rupture of a coronary artery aneurysm, two from rapid early coronary artery obstruction occurring at three and 4 months after initial KD. CONCLUSIONS: Kawasaki disease remains an important cause of mortality and morbidity for children. Diagnostic delay beyond 8 days reduces the chances of successful IVIG therapy in KD. Current studies supported by the Paediatric Surveillance Unit should establish the epidemiology of KD in New Zealand.
Child↗