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Biomedical subjects

L Calandre

Publications and source records attributed to L Calandre.

At least 19 recordsLinked to original sources

Long-term outcome of TIAs, RINDs and infarctions with minimum residuum. A prospective study in Madrid.

A group of patients with transient ischemic attacks (65 cases), reversible ischemic neurologic deficits (37 cases) and infarctions with minimum residuum (41 cases) was included in a prospective follow-up for a mean period of 5.2 years. Most of the patients were treated with acetylsalicylic acid or other antiplatelet agents, or with anticoagulants. Principal complications during follow-up were: cerebral infarction, 15 cases (10.4%); cerebral hematoma, 2 (1.3%); transient ischemic attacks, 17, (11.8%); reversible ischemic neurologic deficits, 9 (6.2%); myocardial infarction, 4 (2.7%); and death, 11 (7.6%). The cumulative incidence for stroke or death was 6.2% for the first year and 14% for the fifth year. There were no significant risk factors for the occurrence of stroke or vascular death on time-related multivariate analysis (Cox). Disabling stroke was less frequent after infarctions with minimum residuum than after transient ischemic attacks or reversible ischemic neurologic deficits.

Adult

[Myoclonic encephalopathy caused by bismuth salts. Efficacy of treatment with dimercaprol].

Three patients with myoclonic encephalopathy caused by bismuth salts are reported, one with the severe and another with the mild form; dimercaprol was effective for the rapid improvement of the symptoms in both. In one of the patients in whom the clearance of bismuth was calculated it was found to be increased after dimercaprol therapy. We think that dimercaprol is an effective drug for the therapy of myoclonic encephalopathy caused by bismuth salts.

Adult

[Ictus].

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Cerebrovascular Disorders

Controlled and uncontrolled thrombocytosis. Its clinical role in essential thrombocythemia.

Only two of 19 patients with spontaneously evolving essential thrombocythemia remained asymptomatic in a 421 patient-month observation. The rest of the patients showed hemorrhagic diathesis (four patients), nonspecific neurological semiology (two patients), and occlusive vascular illness in cerebral, myocardic, arterial, and often multiple locations (total, 12 patients). Peripheral neuropathy was found in five of 10 patients studied. In this series the incidence of cerebral ischemia in the uncontrolled condition was 180 times higher than the epidemiologic expectancy in a population not affected by the disorder. Of 35 ischemic attacks, 22 occurred when the platelet count was more than than 1000 X 10(9)/l, 13 when the count ranged from 650 to 990 X 10(9)/l, and none occurred at counts of less than 650 X 10(9)/l. In contrast, therapeutic control of the thrombocytosis caused all complications to disappear. These findings point out the danger of the natural course of the illness and justify active therapy. At the same time they call into question some of the most commonly used criteria in the diagnosis of essential thrombocythemia.

Adult

Short-term outcome of medically treated patients with transient ischemic attacks, reversible ischemic neurologic deficits and strokes with minimum residuum.

62 patients with transient ischemic attack (TIA), 60 with reversible ischemic neurologic deficit (RIND) and 57 with stroke with minimum residuum (SMR) were followed, in a retrospective survey, from the first 7 days to the 3rd month of evolution. 90 received anticoagulant treatment, 66 antiplatelet treatment and 23 other or no treatment. 5 patients developed strokes with moderate or severe disability; no patient suffered a myocardial infarction or died. No influence of the type of treatment or of the clinical group (TIA, RIND and SMR) on the follow-up complications could be detected. There seems to be a group with a greater risk of developing further cerebral infarction, which is characterized by the occurrence of multiple TIAs for several days before the event.

Anticoagulants

[Treatment of lennox syndrome with medium chain triglycerides (author's transl)].

Twelve cases of Lennox syndrome were treated with a ketogenic diet with medium chain triglycerides during an average period of five months. All the cases were resistant to drug treatment. In five cases seizures disappeared, in five the frequency decreased and two remained without changes. The alertness improved in seven cases. Electroencephalographic records did not show any important improvement. The diet was generally well tolerated and it only had to be discontinued in one case.

Child, Preschool

[Acute confusional syndrome due to bilateral occlusion of the anterior cerebral artery].

We report a case of acute confusional state (ACS) resulted from bilateral occlusion of anterior cerebral artery. This case is outstanding because development of ACS was caused by a focal lesion, without the presentation of focal neurologic signs. Then, cerebrovascular disease must be included in differential diagnosis of ACS, despite the lack of clinically detectable deficit.

Acute Disease